Pulmonary fibrosis,Herbal medicine,Pharmacological agents,Bleomycin,paraquat," /> Pulmonary fibrosis,Herbal medicine,Pharmacological agents,Bleomycin,paraquat,"/> Effects of herbal extracts and compounds and pharmacological agents on pulmonary fibrosis in animal models: A review
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (6): 433-441.doi: 10.1016/S2095-4964(17)60363-7

• Review • Previous Articles     Next Articles

Effects of herbal extracts and compounds and pharmacological agents on pulmonary fibrosis in animal models: A review

Hoda Mojiri-Forushania, Ali Asghar Hemmatib, Mohammad Amin Dehghanic, Ali Reza Malayerib, Hossein Hassan Pourc   

  1. a Abadan School of Medical Sciences, Abadan 6313833177, Iran 
    b Department of Pharmacology, the School of Pharmacy and Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran 
    c Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran
  • Received:2017-04-04 Accepted:2017-06-26 Online:2017-11-15 Published:2017-11-15
  • Contact: Ali Asghar Hemmati, PhD; E-mail: hemmati-aa@yahoo.com

Pulmonary fibrosis, a chronic inflammatory disease that occurs mainly in older adults, is a serious health threat with few effective treatment options. The etiological aspects of pulmonary fibrosis remain unknown, though some factors such as cigarette smoking, viral infections, surfactant protein polymorphisms, and chronic or high doses use of certain drugs are considered to be risk factors for the progression of pulmonary fibrosis. No standard treatments have been introduced in clinic yet. Although glucocorticoids and antioxidant drugs have been administered, the severe and broad-spectrum adverse effects of glucocorticoids limit their use. Efforts to identify novel therapeutic agents with improved safety profiles are therefore ongoing. In this review, the authors have described the effects of herbal extracts and compounds and certain pharmacological agents on pulmonary fibrosis in animal models. These effects indicate that herbs are a promising source of compounds that can play pivotal roles in the treatment of lung fibrosis.

Key words: Pulmonary fibrosis, Herbal medicine, Pharmacological agents, Bleomycin, paraquat

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