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Journal of Integrative Medicine ›› 2021, Vol. 19 ›› Issue (4): 300-310.doi: 10.1016/j.joim.2021.03.007

• Review • Previous Articles     Next Articles

Natural antioxidants in the management of Parkinson’s disease: review of evidence from cell line and animal models

Reem Abdul-Latifa, Ieva Stupansa, Ayman Allahhama, Benu Adhikarib, Thilini Thrimawithanaa   

  1. a Discipline of Pharmacy, School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, VIC 3084, Australia
    b Biosciences and Food Technology, School of Science, Royal Melbourne Institute of Technology University, Bundoora, VIC 3084, Australia
  • Received:2020-10-16 Revised:2021-02-11 Accepted:2021-03-01 Online:2021-08-15 Published:2021-04-07

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease. It results from the death of dopaminergic neurons. The pathophysiological mechanisms in idiopathic PD include the production of α-synuclein and mitochondrial respiratory function-affecting complex I, caused by reactive oxygen species. Therefore, the use of natural antioxidants in PD may provide an alternative therapy that prevents oxidative stress and reduces disease progression. In this review, the effects of hydroxytyrosol, Ginkgo biloba, Withania somnifera, curcumin, green tea, and Hypericum perforatum in PD animal and cell line models are compared and discussed. The reviewed antioxidants show evidence of protecting neural cells from oxidative stress in animal 
and cell models of PD. However, the clinical efficacy of these phytochemicals needs to be optimised and further investigated.

Key words: Parkinson’s disease, Neurodegeneration, Plant, Alternative and complementary medicine

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