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Journal of Integrative Medicine ›› 2023, Vol. 21 ›› Issue (2): 130-135.doi: 10.1016/j.joim.2023.01.004

• Review • Previous Articles     Next Articles

Therapeutic potential of rutin in male infertility: A mini review

Damilare Emmanuel Rotimi a b, Tobiloba Christiana Elebiyo a b, Oluwafemi Adeleke Ojo c   

  1. SDG 03 Group–Good Health & Well-being, Landmark University, Omu-Aran 251101, Kwara State, Nigeria
    Department of Biochemistry, Landmark University, Omu-Aran 251101, Kwara State, Nigeria
    Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo 232101, Osun State, Nigeria
  • Received:2022-09-09 Accepted:2022-11-14 Online:2023-03-20 Published:2023-04-06
  • Contact: Oluwafemi Adeleke Ojo

Male infertility has become a problem worldwide, and recent research has emphasized the development of more effective therapy options. Among natural compounds, rutin has been widely studied for its potential to treat dysfunction related to male infertility, including a reduction in sperm quality, spermatogenesis disruption and structural disruption in the testis. A thorough review of scientific literature published in several databases, including Google Scholar, PubMed/MEDLINE and Scopus, was used to synthesize the present state of research on the role of rutin in male reproductive health. Rutin has been shown to possess antiapoptotic, antioxidant and anti-inflammatory activities, among others, which are crucial in the management of male infertility. Numerous investigations have shown that rutin protects against male infertility and have explored the underlying mechanisms involved. The present review, therefore, assesses the therapeutic mechanisms involved in male infertility treatment using rutin. Rutin was able to mitigate the induced oxidative stress, apoptosis, inflammation, and related physiological processes that can cause testicular dysfunction.

Key words: Antioxidant, Inflammation, Rutin, Sperm, Testicular function

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