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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 17-19.doi: 10.3736/jcim20040107

• Original Clinical Research • Previous Articles     Next Articles

Effect of kidney-warming and astringent therapy on plasma endothelin and interleukin-2 receptor in patients with nephrotic syndrome

Hui Lu1, Yan-yan Wang2, Mei-zhu Guo3, Chun-li Wang4   

  1. 1.Department of Internal Medicine , No . 211 Hospital of PLA , Haerbin , Heilongjiang Province 150080 , China
    2.Department of Rheumatic Diseases, Gene ral Hospital of PLA , Beijing 100853 , China
    3.Department of Inte rnal Medicine, Baoshan Hospital of Traditional Chinese Medicine , Shanghai 200445 , China;
    4.Shanghai Unive rsity of Tr aditional Chinese Medicine,Shanghai 201203 , China
  • Online:2004-01-20 Published:2018-10-25

Objective: To explore the effect and mechanism of kidney-warming and astringent therapy in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and to observe the change of plasma endothelin and interleukin-2 receptor after treatment. Metheds: Forty-four patients were randomly divided into conventional steroid treated group (control group, 20 cases) and conventional steroid plus kidney-warming and astringent therapy treated group (treatment group, 24 cases). The levels of plasma endothelin (ET), soluable interleukin-2 receptor (sIL-2) were observed. Results: Before treatment, plasma ET and sIL-2 in the patients were significantly higher than those in healthy people (P <0.01). After treatment, the ET and sIL-2 levels were obviously improved in both treated groups (P <0.05) and the improvement in the treatment group was more obvious. The difference between the two treated groups after treatment was significant (P <0.05).Conclusion: Conventional treatment plus kidney-warming and astringent therapy can effectively improve the levels of plasma ET and sIL-2 in treating nephrotic syndrome patients with deficiency of spleen and kidney yang and overflow of water, and hence alleviate the damage of renal tissue.

Key words: nephrotic syndrome, kidney-warming and astringent therapy, endothelin, soluable interleukin-2 receptor

CLC Number: 

  • R692

Tab 1

Comparison of biochemical tests in 2 groups before and after treatment (ヌ±S)"

Urine protein
(g/24 h)
Control groupBefore treatment2018.2±0.88.6±4.47.6±2.3138.9±12.3180.3±38.698.3±40.6
After treatment2028.6±4.3*5.9±3.1*6.3±1.3125.3±11.6178.1±30.298.3±40.2
Treatment groupBefore treatment2419.6±1.88.9±4.47.9±2.3139.9±13.3180.9±35.6108.3±44.6
After treatment2434.1±3.3*

Tab 2

Comparison of plasma ET and sIL-2R of 3 groups (ヌ±S)"

Control groupBefore treatment20138.2±10.8**258.6±94.4**
After treatment2088.6±9.3203.9±93.1
Treatment groupBefore treatment24139.6±13.8**268.9±94.6**
After treatment2460.1±13.3△▲155.6±82.1△▲
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