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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (3): 251-255.doi: 10.3736/jcim20060306

• Original Clinical Research • Previous Articles     Next Articles

Effects of Xuezhikang Capsules on vascular endothelial function and redox status in patients with coronary heart disease

Yan-sheng Huang1, Shu-ren Wang1, Yan-fang Zhi1, Shen-yan Kong2, Lin Sun3, Yu Wu3, Jian-min Lu3, Fu-min Dai3   

  1. 1. Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province 610041, China;
  • Online:2006-05-31 Published:2006-05-15

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Objective

To explore the effects of Xuezhikang Capsules (ZXKC) and probucol on blood lipids, vascular endothelial functions and redox status in patients with coronary heart disease.

Methods

One hundred and twelve patients with coronary heart disease were randomly divided into XZKC-treated group and probucol-treated group, 56 in each. Before and after 8-week treatment, the blood levels of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), nitric oxide (NO), endothelin-1 (ET-1), reduced glutathione (GSH) and oxidized glutathione (GSSG) were all measured in both groups. The GSH/GSSG redox potential (Eh) was calculated according to the Nernst equation.

Results

In the XZKC-treated group, the blood levels of TC, LDL-C and TG were significantly decreased after 8-week treatment as compared with those before treatment. The blood levels of TC and LDL-C were also significantly decreased in the probucol-treated group as compared with those before treatment. In the XZKC-treated group, the blood levels of ET-1 and GSSG and the GSH/GSSG Eh after treatment were all significantly lower than those before treatment, whereas the blood levels of GSH and NO, the NO/ET-1 ratio, and the GSH/GSSG ratio after treatment were all significantly higher than those before treatment.

Conclusion

The XZKC or probucol treatment can yield a significant decrease in blood lipids in patients with coronary heart disease. Furthermore, XZKC exerts effective protection on vascular endothelial function, and can make GSH/GSSG redox status shift towards deoxidation

Key words: Xuezhikang Capsules, Coronary heart disease, Nitric oxide, Endothelin-1, Glutathione

CLC Number: 

  • R972.6

Table 1

Changes of blood concentrations of TC, LDL-C and TG in two groups (ヌ±S , mmol/L)"

Group n TC LDL-C TG
XZKC-treated
Before treatment 56 5.68±1.47 3.43±1.36 1.73±0.66
After treatment 55 3.94±1.36** 2.28±1.11** 1.54±0.59*△
Probucol-treated
Before treatment 56 5.73±1.52 3.37±1.35 1.72±0.67
After treatment 53 4.15±1.29** 2.56±1.06** 1.69±0.57

Table 2

Changes of blood levels of NO and ET-1 in two groups（ヌ±S ）"

Group n NO (μmol/L) ET-1 (ng/L) NO/ET-1 ratio
XZKC-treated
Before treatment 56 48.41±16.53 154.43±63.06 0.33±0.16
After treatment 55 64.40±18.86**△△ 121.71±59.11*△ 0.54±0.19**△△
Probucol-treated
Before treatment 56 48.13±15.92 154.77±62.35 0.34±0.17
After treatment 53 49.42±17.51 151.36±58.56 0.35±0.17

Table 3

Changes of blood concentrations of GSH and GSSG and Eh (GSSG/GSH) in two groups（ヌ±S ）"

Group n GSH (μmol/L) GSSG (μmol/L) GSH/GSSG ratio Eh (GSSG/GSH) (mV)
XZKC-treated
Before treatment 56 286.11±38.23 33.93±1.74 8.65±1.18 –142.3±4.34
After treatment 55 321.27±56.47**△△ 30.42±1.59*△ 10.56±1.70**△△ –146.1±4.39**△△
Probucol-treated
Before treatment 56 285.91±38.05 34.03±1.72 8.67±1.21 –143.3±4.37
After treatment 53 289.46±54.89 33.28±1.66 8.99±1.27 –142.3±3.35
[1] 陆宗良, 赵水平, 叶平 , 等. 临床血脂研究新进展(第1版)[M]. 北京: 中华医学电子音像出版社, 2005,( 第1版):106-114
[2] Harrison D, Griendling KK, Landmesser U , et al. Role of oxidative stress in atherosclerosis[J]. Am J Cardiol, 2003,91(3A):7A-11A
doi: 10.1016/S0002-9149(02)03144-2 pmid: 12645638
[3] 中华医学会心血管病学分会, 中华心血管病杂志编辑委员会, 中国循环杂志编辑委员会. 急性心肌梗死诊断和治疗指南[J]. 中华心血管病杂志, 2001,29(12):710-725
doi: 10.14164/j.cnki.cn11-5581/r.2015.23.211
[4] Li SK, Ghanem AH, Teng CL , et al. Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model[J]. J Pharm Sci, 2001,90(7):915-931
[5] 胡申江 . 重视动脉粥样硬化“非传统”危险因素的研究[J]. 浙江大学学报(医学版), 2002,31(5):313-315
doi: 10.3785/j.issn.1008-9292.2002.05.001
[6] 叶任高, 陆再英 .内科学 ( 第6版)[M]. 北京: 人民卫生出版社, 2004,( 第6版):263-302
[7] 马旭辉, 张杰 . 中药对内皮素及一氧化氮的调控作用研究进展[J]. 中西医结合学报, 2004,2(2):152-153, 158
[8] Davies IG, Graham JM, Griffin BA , et al. Rapid separation of LDL subclasses by iodixanol gradient ultracentrifugation[J]. Clin Chem, 2003,49(11):1865-1872
doi: 10.1373/clinchem.2003.023366 pmid: 14578318
[9] Wakeyama T, Ogawa H, Iida H , et al. Effects of candesartan and probucol on restenosis after coronary stenting: results of insight of stent intimal hyperplasia inhibition by new angiotensin Ⅱ receptor antagonist(ISHIN) trial[J]. Circ J, 2003,67(6):519-524
[10] Liu ZG, Yu XY . Effects of Xuezhikang Capsule on blood lipids, platelet activation and coagulation-fibrinolysis activity in patients with hyperlipidemia[J]. Chin J Integr Med, 2004,10(4):259-262
doi: 10.1007/BF02836425
[11] Janiszewski M, Pedro MA, Scheffer RC , et al. Inhibition of vascular NADH/NADPH oxidase activity by thiol reagents: lack of correlation with cellular glutathione redox status[J]. Free Radic Biol Med, 2000,29(9):889-899
[12] Nemeth I, Orvos H, Boda D . Blood glutathione redox status in gestational hypertension[J]. Free Radic Biol Med, 2001,30(7):715-721
doi: 10.1016/S0891-5849(00)00516-5 pmid: 11275471
[13] Cargnoni A, Ceconi C, Gaia G , et al. Cellular thiols redox status: a switch for NF-kappaB activation during myocardial post-ischaemic reperfusion[J]. J Mol Cell Cardiol, 2002,34(8):997-1005
doi: 10.1006/jmcc.2002.2046
[14] Kuppusamy P, Li H, Ilangovan G , et al. Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels[J]. Cancer Res, 2002,62(1):307-312
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