SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (4): 352-354.doi: 10.3736/jcim20080405

• Original Clinical Research • Previous Articles     Next Articles

Risk factor analysis of severe acute pancreatitis complicated by pancreatic encephalopathy

Jia Guo, Zong-wen Huang(), Jing-yun Fan, Yan chen, Fu-qian He   

  1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2007-09-24 Online:2008-04-20 Published:2008-04-15
  • Contact: HUANG Zong-wen E-mail:huangzongwen@medmail.com.cn

RichHTML

2

PDF (PC)

59

Like

Objective: To study the risk factors for severe acute pancreatitis (SAP) complicated by pancreatic encephalopathy (PE).
Methods: Clinical data from 255 patients with SAP from January 2005 to December 2006 were reviewed. Thirty-one SAP patients had PE, and 224 SAP patients did not. Clinical characteristics of SAP patients in both PE group and non-PE group were analyzed.'
Results: Ranson scale and the incidence rates of acute respiratory distress syndrome (ARDS), renal failure, hypoproteinemia, hypocalcemia and hyperglycosemia in PE group were higher than those in non-PE group (P<0.05). There were no significant differences in acute physiology and chronic health evaluation Ⅱ and CT severity index scales, the activities of amylase and lipase, the incidence rate of liver function failure, the infection rate and the operability between the PE group and the non-PE group (P>0.05) . Multivariate logistic regression analysis showed that ARDS and hyperglycosemia were high risk factors. Cure rate in PE group was higher than that in non-PE group.
Conclusion: Nosogenesis of PE is the result of multiple factors. ARDS and hyperglycosemia may be the high risk factors for PE.

Key words: acute necrotizing pancreatitis, pancreatic encephalopathy, risk factors

CLC Number: 

  • R576.1

Table 1

Pathogenetic conditions before treatment in two groups ($\bar{x}$±s)"

Group n APACHEⅡ scale CTSI scale Ranson scale
PE 31 15.4±6.9 6.4±2.7 5.8±1.7*
Non-PE 224 9.5±7.0 5.1±2.6 3.7±2.3

Table 2

Serum amylase and lipase activities before treatment in two groups (M)"

Group n Amylase actinity (U/L) Lipase activity (U/L)
PE 31 390.0 534.5
Non-PE 224 643.0 648.0
[1] Group of Pancreatopathy, Branch Association for Diseases of Digestive System, Chinese Medical Association . Draft criteria for diagnosis and treatment of acute pancreatitis in China[J]. Yi Xian Bing Xue, 2004,4(1):35-38
doi: 10.3760/cma.j.issn.1674-1935.2004.01.012
中华医学会消化病学分会胰腺疾病学组. 中国急性胰腺炎诊治指南(草案)[J]. 胰腺病学, 2004,4(1):35-38
doi: 10.3760/cma.j.issn.1674-1935.2004.01.012
[2] Estrada RV, Moreno J, Martinez E , et al. Pancreatic encephalopathy[J]. Acta Neurol Scand, 1979,59(2-3):135-139
[3] Zhang HY, Xia Q . Review of the Chinese literature about pancreatic encephalopathy in recent 15 years[J]. Zhongguo Xun Zheng Yi Xue Za Zhi, 2005,5(1):71-74
张鸿彦, 夏庆 . 胰性脑病的中文文献15年回顾[J]. 中国循证医学杂志, 2005,5(1):71-74
[4] Liu XB, Jiang JM, Huang ZW , et al. Clinical study on the treatment of severe acute pancreatitis by integrated traditional Chinese medicine and Western medicine[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2004,35(2):204-208
doi: 10.3969/j.issn.1672-173X.2004.02.017
刘续宝, 蒋俊明, 黄宗文 , 等. 中西医结合治疗重症急性胰腺炎的临床研究(附1 376例报告)[J]. 四川大学学报 (医学版), 2004,35(2):204-208
doi: 10.3969/j.issn.1672-173X.2004.02.017
[5] Qiu F, Lu XS, Li YX , et al. Prospective clinical study on preventing effects of low molecular weight heparin on pancreatic encephalopathy in severe acute pancreatitis[J]. Zhonghua Gan Dan Wai Ke Za Zhi, 2006,12(9):622-624
邱氟, 吕新生, 力宜雄 , 等. 低分子量肝素预防重症急性胰腺炎并发胰性脑病的前瞻性临床研究[J]. 中华肝胆外科杂志, 2006,12(9):622-624
[1] Xue-yang Song, Si-jing Wang, Zhao-xia Xu, Yi-ming Hao, Lu Feng, Xiao-dong Ding, Hui Gao, Yi-qin Wang. Preliminary study on phonetic characteristics of patients with pulmonary nodules. Journal of Integrative Medicine, 2020, 18(6): 499-504.
[2] Jing-yun Fan, Zong-wen Huang, Jia Guo. Value of four scoring systems for predicting prognosis of severe acute pancreatitis. Journal of Chinese Integrative Medicine, 2009, 7(1): 34-40.
[3] Min Zhang, De-zeng Zhu, Zhao-shen Li, Xian-bao Zhan. Red peony root decoction in treatment of severe acute pancreatitis: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(6): 569-575.
[4] Yong-hong Li, Zong-wen Huang, Ping Xue, Jia Guo, Fu-qian He, Zheng You, Zheng-rong Wang. Effects of Chaiqin Chengqi Decoction on activation of nuclear factor-κB in pancreas of rats with acute necrotizing pancreatitis. Journal of Chinese Integrative Medicine, 2008, 6(2): 180-184.
[5] Li-hui Dang, Xiao-nan Yang, Qing Xia. Protective effects of Chaiqin Chengqi Decoction on isolated pancreatic acinar cells in acute pancreatitis rats and the mechanisms. Journal of Chinese Integrative Medicine, 2008, 6(2): 176-179.
[6] Xiao-dong Guan, Yu-fang Wu, Wen Zhao. Clinical observation on treatment of IgA nephropathy with Huobahuagen Tablets and irbesartan. Journal of Chinese Integrative Medicine, 2005, 3(5): 366-369.
[7] Kai-wen Hu, Fen Wang, Yang Cao, Xiu-lan He, Ming-huan Zuo, Wen-qiang Chen. Risk factors of traditional Chinese medical syndromes in moderate and advanced lung cancer patients with concurrent fungal pneumonia. Journal of Chinese Integrative Medicine, 2004, 2(5): 337-339.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3