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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (3): 251-255.doi: 10.3736/jcim20060306

• Original Clinical Research • Previous Articles     Next Articles

Effects of Xuezhikang Capsules on vascular endothelial function and redox status in patients with coronary heart disease

Yan-sheng Huang1, Shu-ren Wang1, Yan-fang Zhi1, Shen-yan Kong2, Lin Sun3, Yu Wu3, Jian-min Lu3, Fu-min Dai3   

  1. 1. Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province 610041, China;
  • Online:2006-05-31 Published:2006-05-15

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Objective

To explore the effects of Xuezhikang Capsules (ZXKC) and probucol on blood lipids, vascular endothelial functions and redox status in patients with coronary heart disease.

Methods

One hundred and twelve patients with coronary heart disease were randomly divided into XZKC-treated group and probucol-treated group, 56 in each. Before and after 8-week treatment, the blood levels of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), nitric oxide (NO), endothelin-1 (ET-1), reduced glutathione (GSH) and oxidized glutathione (GSSG) were all measured in both groups. The GSH/GSSG redox potential (Eh) was calculated according to the Nernst equation.

Results

In the XZKC-treated group, the blood levels of TC, LDL-C and TG were significantly decreased after 8-week treatment as compared with those before treatment. The blood levels of TC and LDL-C were also significantly decreased in the probucol-treated group as compared with those before treatment. In the XZKC-treated group, the blood levels of ET-1 and GSSG and the GSH/GSSG Eh after treatment were all significantly lower than those before treatment, whereas the blood levels of GSH and NO, the NO/ET-1 ratio, and the GSH/GSSG ratio after treatment were all significantly higher than those before treatment.

Conclusion

The XZKC or probucol treatment can yield a significant decrease in blood lipids in patients with coronary heart disease. Furthermore, XZKC exerts effective protection on vascular endothelial function, and can make GSH/GSSG redox status shift towards deoxidation

Key words: Xuezhikang Capsules, Coronary heart disease, Nitric oxide, Endothelin-1, Glutathione

CLC Number: 

  • R972.6

Table 1

Changes of blood concentrations of TC, LDL-C and TG in two groups (ヌ±S , mmol/L)"

Group n TC LDL-C TG
XZKC-treated
Before treatment 56 5.68±1.47 3.43±1.36 1.73±0.66
After treatment 55 3.94±1.36** 2.28±1.11** 1.54±0.59*△
Probucol-treated
Before treatment 56 5.73±1.52 3.37±1.35 1.72±0.67
After treatment 53 4.15±1.29** 2.56±1.06** 1.69±0.57

Table 2

Changes of blood levels of NO and ET-1 in two groups（ヌ±S ）"

Group n NO (μmol/L) ET-1 (ng/L) NO/ET-1 ratio
XZKC-treated
Before treatment 56 48.41±16.53 154.43±63.06 0.33±0.16
After treatment 55 64.40±18.86**△△ 121.71±59.11*△ 0.54±0.19**△△
Probucol-treated
Before treatment 56 48.13±15.92 154.77±62.35 0.34±0.17
After treatment 53 49.42±17.51 151.36±58.56 0.35±0.17

Table 3

Changes of blood concentrations of GSH and GSSG and Eh (GSSG/GSH) in two groups（ヌ±S ）"

Group n GSH (μmol/L) GSSG (μmol/L) GSH/GSSG ratio Eh (GSSG/GSH) (mV)
XZKC-treated
Before treatment 56 286.11±38.23 33.93±1.74 8.65±1.18 –142.3±4.34
After treatment 55 321.27±56.47**△△ 30.42±1.59*△ 10.56±1.70**△△ –146.1±4.39**△△
Probucol-treated
Before treatment 56 285.91±38.05 34.03±1.72 8.67±1.21 –143.3±4.37
After treatment 53 289.46±54.89 33.28±1.66 8.99±1.27 –142.3±3.35
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