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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 585-588.doi: 10.3736/jcim20060608

• Original Clinical Research • Previous Articles     Next Articles

Clinical observation on treatment of 43 women with polycystic ovary syndrome based on syndrome differentiation

Li-na Jia, Xing-juan Wang   

  1. Department of Gynecology of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2006-11-30 Published:2006-11-15

Objective

To investigate the therapeutic effect of treatment based on syndrome differentiation and its influence on the serum levels of testosterone and insulin in women with polycystic ovary syndrome (PCOS).

Methods

Forty-three women, diagnosed with PCOS as well as syndrome of kidney yin deficiency or syndrome of spleen qi deficiency, were enrolled in the study. Twenty-five PCOS women with syndrome of kidney yin deficiency were treated with traditional Chinese herbs for nourishing yin to reduce fire (nourishing yin group), and 18 PCOS women with syndrome of spleen qi deficiency were treated with herbs for invigorating spleen and replenishing qi (replenishing qi group). Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and the serum levels of insulin and testosterone before and after treatment were detected.

Results

Among the 43 cases, 20 cases had high serum testosterone level, in which 13 cases with syndrome of kidney yin deficiency, 7 cases with syndrome of spleen qi deficiency, but the difference had no statistic significance; 17 cases had high serum insulin level, in which 11 cases with syndrome of spleen qi deficiency, 6 cases with syndrome of kidney yin deficiency, the difference had statistic significance (P<0.05). In nourishing yin group, the serum levels of insulin and testosterone declined after treatment (P<0.05), and BMI, WHR and WC showed no significant changes. In replenishing qi group, the serum level of insulin declined after treatment (P<0.01) , and BMI, WHR, WC and the serum level of testosterone showed no significant changes.

Conclusion

Traditional Chinese herbs for nourishing yin to reduce fire can significantly reduce the serum levels of testosterone and insulin in PCOS women with syndrome of kidney yin deficiency, and herbs for invigorating spleen and replenishing qi can significantly reduce the serum level of insulin in PCOS women with syndrome of spleen qi deficiency.

Key words: Polycystic ovary syndrome, Syndrome differentiation and treatment, Testosterone, Insulin

CLC Number: 

  • R711.75

Table 1

Changes of BMI, WHR, WC, testosterone and insulin in 43 PCOS women before and after treatment(ヌ±S )"

TimenBMI (kg/m2)WHRWC (cm)Testosterone (μg/L)Insulin (mU/L)
Before treatment4322.78±4.390.82±0.0776.2±10.22.53±1.5415.47±11.50
After treatment4322.59±3.800.81±0.0675.1±8.32.16±0.92*12.19±2.37**

Table 2

Changes of BMI, WHR, WC, testosterone and insulin in nourishing yin group and replenishing qi group before and after treatment(ヌ±S )"

GroupnBMI (kg/m2)WHRWC (cm)Testosterone (μg/L)Insulin (mU/L)
Nourishing yin group
Before treatment2522.39±4.280.80±0.0774.8±9.12.54±1.1512.85±7.46
After treatment2522.03±3.710.80±0.0674.1±8.52.05±0.90*9.59±1.36*
Replenishing qi group
Before treatment1823.30±4.610.84±0.0777.9±11.62.57±1.9919.20±14.94
After treatment1823.33±3.900.83±0.0776.5±8.02.27±0.9610.99±8.78**
[1] Dunaif A.Hyperandrogenic anovulation(PCOS): a uniquic disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus[J].Am J Med,1995,98(Suppl):33-39
[2] The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on disgnostic criteria and long-term health risks related to polycystic ovary syndrome[J].Fertil Steril,2004,81(1):19-25
doi: 10.1016/j.fertnstert.2003.10.004
[3] 沈自尹, 王文健.中医虚证辨证参考标准[J].中西医结合杂志,1986,6(10):598
[4] 吴咸中, 高金亮.脾虚证的现代研究(第1版)[M].天津: 天津科技翻译出版公司,1992,(第1版):47-48
[5] 中华人民共和国卫生部.中药新药临床研究指导原则(第一辑)(第1版)[M].北京: 人民卫生出版社,1993,(第1版):241, 276
[6] Kiddy DS, Hamilton-Fairley D, Bush A, et al.Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovarian syndrome[J].Clin Endocrinol (Oxf),1992,36(1):105-111
[7] Nestler JE, Powers LP, Matt DW, et al.A direct effect of hyperinsulinemia on serum sex hormone binding globulin levels in obese women with the polycystic ovary syndrome[J].J Clin Endocrinol Metab,1991,72():83-89
[8] 王兴娟. 承师心悟——滋阴降火法治疗多囊卵巢综合征[J].上海中医药杂志,1999,(12):22-23
[9] 王兴娟, 戴婷, 贾丽娜.肾虚型多囊卵巢综合征与LH, T的相关性研究[J].上海中医药杂志,2006,40(8):40-41
doi: 10.7666/d.y772985
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