Megsin基因E1-5’UTR区A267G与免疫球蛋白A型肾病阴虚证的相关性

doi:10.3736/jcim20080506

Abstract

Objective: To observe the correlation between traditional Chinese medicine (TCM) syndromes ("deficiency of qi and yin" and "deficiency of liver yin and kidney yin") and A267G in 5'-untranslated region within exonal of megsin gene, and to search the substantial genetic basis for micro-differentiation of TCM syndromes in primary immunoglobulin A nephropathy (IgAN).
Methods: A total of 120 IgAN cases meeting the diagnostic criteria were enrolled. The sequence of single nucleotide polymorphism (SNP) of A267G in 5'-untranslated region within exonal of megsin gene was tested. The correlation between SNP and TCM syndromes was observed.
Results: There were 83 cases carrying GG genotype, 34 cases carrying GA genotype and 3 cases carrying AA genotype in 120 cases of primary IgAN. There was a high proportion of "deficiency of liver yin and kidney yin" in IgAN cases with AA and GA genotypes, and a high proportion of "deficiency of qi and yin" in IgAN cases with GG genotype (P<0.01). Odds ratio in TCM syndrome distribution between GG genotype and GA plus AA genotype was 9.800, and 95% confidence interval was 3.969-24.199. The discrepancy also resided in IgAN patients with different genders and ages.
Conclusion: A267G in 5'-untranslated region within exonal of the megsin gene may be one of the substantial genetic basis for differentiating "deficiency of liver yin and kidney yin" syndrome and "deficiency of qi and yin" syndrome in primary IgAN.

Key words: immunoglobulin A nephropathy, polymorphism, single nucleotide, gene, megsin

CLC Number:

R692.9

Yi-fei Zhong, Yi-ping Chen, Yue-yi Deng, Nan Chen, Zhao-hui Wang. Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene. Journal of Chinese Integrative Medicine, 2008, 6(5): 463-467.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080506

http://www.jcimjournal.com/EN/Y2008/V6/I5/463

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References 8

[1]	Barratt J, Feehally J . IgA Nephropathy[J]. J Am Soc Nephrol, 2005,16(7):2088-2097 doi: 10.1681/ASN.2005020134
[2]	Li LS, Liu ZH . Epidemiologic data of renal diseases from a single unit in China: analysis based on 13,519 renal biopsies[J]. Kidney Int, 2004,66(3):920-923 doi: 10.1111/j.1523-1755.2004.00837.x
[3]	Chen XM, Chen YP, Chen YP , et al. Multicenter prospective study on relationship of TCM syndrome type and renal pathology in 286 patients with IgA nephropathy[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2004,24(2):101-105 doi: 10.7661/CJIM.2004.2.101
	陈香美, 陈以平, 谌贻璞 , 等. 286例IgA肾病中医辨证与肾脏病理关系的多中心前瞻性研究[J]. 中国中西医结合杂志, 2004,24(2):101-105 doi: 10.7661/CJIM.2004.2.101
[4]	Wang ZH, Chen N, Pan XX , et al. Association of single nucleotide polymorphism of megsin gene with IgA nephropathy[J]. Zhonghua Yi Xue Za Zhi, 2006,86(19):1337-1341 doi: 10.3760/j:issn:0376-2491.2006.19.010
	王朝晖, 陈楠, 潘晓霞 , 等. Megsin基因单核苷酸多态性与IgA肾病相关性研究[J]. 中华医学杂志, 2006,86(19):1337-1341 doi: 10.3760/j:issn:0376-2491.2006.19.010
[5]	Wang ZH, Chen N, Wang WM , et al. Search and confirmation of single nucleotide polymorphism in susceptibility genes for IgA nephropathy[J]. Zhonghua Shen Zang Bing Za Zhi, 2006,22(5):282-285 doi: 10.3760/j.issn:1001-7097.2006.05.007
	王朝晖, 陈楠, 王伟铭 , 等. IgA肾病候选基因单核苷酸多态性的搜寻和确定[J]. 中华肾脏病杂志, 2006,22(5):282-285 doi: 10.3760/j.issn:1001-7097.2006.05.007
[6]	Miyata T, Nangaku M, Suzuki D , et al. A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy[J]. J Clin Invest, 1998,102(4):828-836 doi: 10.1172/JCI2450 pmid: 9710452
[7]	Wang HY. Nephrology(2nd ed)[M]. Beijing: People's Medical Publishing House, 2001,( 2nd ed):367
	王海燕.肾脏病学( 第2版)[M]. 北京: 人民卫生出版社, 2001,( 第2版):367
[8]	Li CD . Review and prospect for correlative study on differentiation of symptoms and signs on TCM and gene as well as its products[J]. Hunan Zhong Yi Yao Dao Bao, 2000,6(6):6-8
	李灿东 . 中医辨证与基因及其产物相关性研究的回顾与展望[J]. 湖南中医药导报, 2000,6(6):6-8

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Syndrome type	n	Polymorphism of A267G in 5'-untranslated region within exonal of the megsin gene			Total
Syndrome type	n	GA	AA	GG	Total
Deficiency of qi and yin	72	9 (12.50%)	0 (0.00%)	63 (87.50%)	72 (100%)
Deficiency of liver yin and kidney yin	48	25 (52.08%)	3 (6.25%)	20 (41.67%)	48 (100%)
Total	120	34 (28.33%)	3 (2.50%)	83 (69.17%)	120 (100%)

Sex	Syndrome type	Polymorphism of A267G in 5'-untranslatedregion within exonal of the megsin gene			Total
Sex	Syndrome type	GG	GA	AA
Male
	Deficiency of qi and yin	28 (87.50%)	4 (12.50%)	0 (0.00%)	32 (100%)
	Deficiency of liver yin and kidney yin	10 (45.45%)	11 (50.00%)	1 (4.55%)	22 (100%)
	Total	38 (70.37%)	15 (27.78%)	1 (1.85%)	54 (100%)
Female
	Deficiency of qi and yin	35 (87.50%)	5 (12.50%)	0 (0.00%)	40 (100%)
	Deficiency of liver yin and kidney yin	10 (38.46%)	14 (53.85%)	2 (7.69%)	26 (100%)
	Total	45 (68.18%)	19 (28.79%)	2 (3.03%)	66 (100%)

Age	Syndrome type	Polymorphism of A267G in 5'-untranslated region within exonal of the megsin gene			Total
Age	Syndrome type	GG	GA	AA	Total
<35 years
	Deficiency of qi and yin	31 (86.11%)	5 (13.89%)	0 (0.00%)	36 (100%)
	Deficiency of liver yin and kidney yin	9 (42.86%)	10 (47.62%)	2 (9.52%)	21 (100%)
	Total	40 (70.18%)	15 (26.32%)	2 (3.50%)	57 (100%)
≥35 years
	Deficiency of qi and yin	32 (88.89%)	4 (11.11%)	0 (0.00%)	36 (100%)
	Deficiency of liver yin and kidney yin	11 (40.74%)	15 (55.56%)	1 (3.70%)	27 (100%)
	Total	43 (68.25%)	19 (30.16%)	1 (1.59%)	63 (100%)

Correlation between traditional Chinese medicine syndromes in primary immunoglobulin A nephropathy and A267G in 5'-untranslated region within exonal of megsin gene

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