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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 788-792.doi: 10.3736/jcim20080804

• Original Clinical Research • Previous Articles     Next Articles

Factor analysis of traditional Chinese medicine syndromes in 815 patients with unstable angina

Jie Wang, Qing-yong He(), Hai-xia Li, Yu-tao Fang   

  1. Department of Cardiology,Guanganmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China
  • Received:2007-12-25 Online:2008-08-20 Published:2008-08-15

Objectiye: To explore the laws of tracitional Chinese medane (TCM) syndromes in unstable angna, and to establish the prelim'nary dagnostic criteria for TCM syndromes .
Methods: Multi-center prospective research on TCM syndromes in 815 cases cf unstable ang'na was done with the nonlinear dmenson reduction by factor analyss .
Results: There were five extracted factors in factor analyss : F1, F2, F3, F4 and F5 . F1 was yin defidency of heart and kichey, F2 was defidency of both heart and spleen , F3 was interm'n^ed phlegm and blood stass, F4 was q Cefidency and blood stass, and F5 was yang Cefidency and coagilated cold . Q Cefidency and blood stass (F4) syndrome accounted for the maximum proportion . The diagnostic criteria for TCM syndromes were prelimnarily and respectively established.
Conclusion: Q defi0-910/ and blood stasis is the key factor of pathogenesis . The factor analysis can help us cassify tracitional Chinese mecione syndromes and establish the preliminary ciagnostic criteria.

Key words: angna, unstable, syncTome complex, factor anayss, reference standards

CLC Number: 

  • R541.42

Table 1

Factor analysis of traditional Chinese medicine syndromes in 815 UA patients"

Common factor 1 Common factor 2 Common factor 3 Common factor 4 Common factor 5
Symptom Weight Symptom Weight Symptom Weight Symptom Weight Symptom Weight
X2 0.689 9 X26 0.545 5 X38 0.610 4 X65 0.344 6 X6 0.444 5
X31 0.672 0 X14 0.496 9 X72 0.724 2 X12 0.334 7 X52 0.496 9
X30 0.632 0 X12 0.429 2 X5 0.594 9 X72 0.319 8 X54 0.387 1
X17 0.530 9 X18 0.480 8 X75 0.597 9 X56 0.276 8 X55 0.301 0
X19 0.534 3 X27 0.496 8 X65 0.463 8 X48 0.280 8 X53 0.317 9
X62 0.508 7 X35 0.455 8 X1 0.493 4 X17 0.254 2 X4 0.295 5
X74 0.528 4 X56 0.430 0 X22 0.359 4 X71 0.249 0 X68 0.259 3
X9 0.493 5 X25 0.447 3 X57 0.350 3 X32 0.224 2 X63 0.209 8
X4 0.420 5 X24 0.445 7 X61 0.326 5 X50 0.224 9 X42 0.212 7
X52 0.421 0 X15 0.363 4 X48 0.393 6 X7 0.215 0 X32 0.202 2
X64 0.448 3 X21 0.390 2 X39 0.313 9 X55 0.217 8 X5 0.164 8
X73 0.394 9 X28 0.383 2 X20 0.299 5 X3 0.233 2 X51 0.187 9
X54 0.394 3 X13 0.403 1 X70 0.297 9 X69 0.201 0 X66 0.172 6
X45 0.362 4 X3 0.391 8 X51 0.292 5 X33 0.198 2 X70 0.156 9
X15 0.363 4 X8 0.367 2 X25 0.263 9 X8 0.184 5 X12 0.129 5

Table 2

Composition ratio of five traditional Chinese medicine syndromes in 815 UA patients"

Factor Syndrome n Constituent ratio (%)
F1 Yin deficiency of heart and kidney 145 17.79
F2 Deficiency of both heart and spleen 37 4.54
F3 Intermingled phlegm and blood stasis 200 24.54
F4 Deficiency of heart qi and blood stasis 270 33.13
F5 Yang deficiency and coagulated cold 163 20.00

Table 3

Correlation among the five factors (syndromes)"

Factor F1 F2 F3 F4 F5
F1 –0.487 51 0.117 61 0.005 93 0.303 67
F2 0.327 37 –0.043 76 0.409 78 0.366 99
F3 –0.210 18 –0.137 64 0.504 76 0.010 01
F4 0.009 07 0.299 39 0.511 87 0.273 00
F5 –0.438 55 –0.255 82 –0.200 62 0.059 28
[1] Fang YT, Wang SR . An investigation on clinical studies of TCM in preventing and treating angina pectoris of coronary heart disease[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,23(5):338-340
doi: 10.7661/CJIM.2003.5.338
房玉涛, 王硕仁 . 冠心病心绞痛中医药防治临床研究的现状调查[J]. 中国中西医结合杂志, 2003,23(5):338-340
doi: 10.7661/CJIM.2003.5.338
[2] Chen KJ, Lei Y . Strengthen the clinical study of the control of patients with unstable angina[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 1996,16(10):579
doi: 10.7661/CJIM.1996.10.579
陈可冀, 雷燕 . 加强不稳定性心绞痛的防治研究[J]. 中国中西医结合杂志, 1996,16(10):579
doi: 10.7661/CJIM.1996.10.579
[3] Guo L, Wang YY, Zhang ZB . On the annotation of syndrome[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2003,26(2):5-8
郭蕾, 王永炎, 张志斌 . 关于证候概念的诠释[J]. 北京中医药大学学报, 2003,26(2):5-8
[4] Braunwald E, Antman EM. Beasley JW , et al. ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction-2002: Summary article[J]. J Am Coll Cardiol,2002,106:1893- 1900
[5] Hu LS, Zhou Q. Clinical research design of traditional Chinese medicine and SAS programming statistics[M]. Beijing: Academy Press,2004: 45, 68
胡立胜, 周强 . 中医临床研究设计与SAS编程统计分析[M]. 北京: 学苑出版社,2004: 45, 68
[6] Chen QG, Shen CD, Zhang HQ , et al. Application of factor analysis in study of syndrome standardization in Chinese medicine[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2004,10(8):53-56
doi: 10.3969/j.issn.1006-3250.2004.08.022
陈启光, 申春悌, 张华强 , 等. 因子分析在中医证候规范标准研究中的应用[J]. 中国中医基础医学杂志. , 2004,10(8):53-56
doi: 10.3969/j.issn.1006-3250.2004.08.022
[7] Zhang Q, Zhang WT, Wei JJ , et al. Combined use of factor analysis and cluster analysis in classification of traditional Chinese medical syndromes in patients with posthepatitic cirrhosis[J]. Zhong Xi Yi Jie He Xue Bao, 2005,3(1):14-18
张琴, 张文彤, 魏建军 , 等. 公因子和聚类分析联合在肝炎后肝硬化证候分类研究中的应用[J]. 中西医结合学报, 2005,3(1):14-18
[8] Zhang XD . Theory and experimental study of the therapy for warming yang and nourishing yin in treatment of unstable angina pectoris[J].Master's thesis of Nanjing University of Traditional Chinese Medicine, 2005, 1
doi: 10.7666/d.y1008588
张晓东 .温阳养阴法治疗不稳定性心绞痛的理论探讨及实验研究[J].南京中医药大学优秀硕士毕业论文集, 2005, 1
doi: 10.7666/d.y1008588
[9] Wang RK, Yang JP, Li H . Clinical study on LPA in patients with unstable angina treated by Gedan Wenxin decoction[J]. Hunan Zhong Yi Za Zhi, 2007,23(2):5-7
doi: 10.3969/j.issn.1003-7705.2007.02.003
王瑞科, 杨继平, 李红 . 葛丹稳心汤对不稳定性心绞痛患者LPA影响的临床研究[J]. 湖南中医杂志, 2007,23(2):5-7
doi: 10.3969/j.issn.1003-7705.2007.02.003
[10] Liu YQ, Li XP . Clinical observation of combined therapy of Western drugs with Salvia Drop Pill and ligustrazine in treatment of unstable angina pectorisClinical observation of combined therapy of Western drugs with Salvia Drop Pill and ligustrazine in treatment of unstable angina pectoris[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,23(7):544-545
刘耀乾, 李小苹 . 丹参滴丸和川芎嗪配合西药联合治疗不稳定型心绞痛临床观察[J]. 中国中西医结合杂志, 2003,23(7):544-545
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