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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 907-910.doi: 10.3736/jcim20080906

• Original Clinical Research • Previous Articles     Next Articles

Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy

Huo-jun Zhang, Ji-jin Yang(), Wei-xing Wang, Xu Jiang, Yan-jun Mao, Chao-ai Yang, Ji-xiang Guo   

  1. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2008-04-14 Online:2008-09-20 Published:2008-09-15

Objective: To observe and discuss the dynamic changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) and their significance in the patients with primary liver cancer after transarterial chemoembolization (TACE) therapy combined with Jinglong Capsule.
Methods: A total of 48 patients with primary liver cancer, who failed to be treated by major surgery, were randomly divided into two groups: Jinlong Capsule group (TACE therapy plus Jinlong Capsule) and control group (TACE therapy alone). There were 24 cases in each group. The levels of peripheral blood IL-2 and slL-2R were measured before the first TACE and 1, 7 and 15 days after the second TACE respectively by using double-antibody sandwich enzyme-linked immunosorbent assay. The data from Jinlong Capsule group were compared with those from the control group.
Results: The level of sIL-2R in Jinlong Capsule group was significantly lower than that in the control group (P<0.05), while the level of IL-2 was significantly higher than that in the control group (P<0.05).
Conclusion: Jinlong Capsule can significantly improve the lymphocyte function of the patients with primary liver cancer after TACE. The levels of IL-2 and sIL-2R can be considered as the valuable parameters for evaluating the effects on primary liver cancer, and Jinlong Capsule is helpful for the patients with primary liver cancer.

Key words: liver cancer, radiography, interventional, interleukin-2, Jinlong Capsule, randomized controlled trial

CLC Number: 

  • R735.7

Table 1

The serum level of IL-2 at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 490.21±101.33 706.68±135.24 598.38±102.11 668.69±98.11
Jinglong Capsule 24 475.68±95.53 886.79±101.22* 713.45±88.63* 894.75±135.43*
t 0.983 5.374 6.742 8.012

Table 2

The serum level of sIL-2R at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 425.34±101.21 321.19±105.37 397.65±98.54 311.47±103.28
Jinglong Capsule 24 436.11±121.98 273.68±103.12* 302.18±106.44* 255.69±134.26*
t 0.521 5.101 7.214 6.872
[1] El-Shanawani FM, Abdel-Hadi AA, Abu Zikri NB , et al. Clinical significance of aflatoxin, mutant P53 gene and sIL-2 receptor in liver cirrhosis and hepatocellular carcinoma[J]. Egypt Soc Parasitol, 2006,36(1):221-239
[2] Handzel ZT, Barak V, Altman Y , et al. Increased Th1 and Th2 type cytokine production in patients with active tuberculosis[J]. Isr Med Assoc J, 2007,9(6):479-483
doi: 10.1007/s11845-007-0023-0 pmid: 17642401
[3] Sandberg JK, Moll M . Effects of interleukin-2 treatment on CD1d-restricted natural killer T cells[J]. Clin Cancer Res, 2007,13(14):4311-4315
doi: 10.1158/1078-0432.CCR-07-1267 pmid: 17634562
[4] Garrod KR, Wei SH, Parker I , et al. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets[J]. Proc Natl Acad Sci U S A, 2007,104(29):12081-12086
doi: 10.1073/pnas.0702867104
[5] Porta C, Paglino C, Imarisio I , et al.Cytokine-based immunotherapy for advanced kidney cancer: past results and future perspectives in the era of molecularly targeted agents[J].ScientificWorldJournal, 2007, 7: 837-849
doi: 10.1100/tsw.2007.154
[6] Barker SE, Grosse SM, Siapati EK , et al. Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12[J]. Br J Cancer, 2007,97(2):210-217
doi: 10.1038/sj.bjc.6603857 pmid: 2360308
[7] Ottaiano A, Leonardi E, Simeone E , et al. Soluble interleukin-2 receptor in stage I-III melanoma[J]. Cytokine, 2006,33(3):150-155
doi: 10.1016/j.cyto.2006.01.002 pmid: 16517174
[8] Izzo F, Cremona F, Delrio P , et al. Soluble interleukin-2 receptor levels in hepatocellular cancer: a more sensitive marker than alfa fetoprotein[J]. Ann Surg Oncol, 1999,6(2):178-185
doi: 10.1007/s10434-999-0178-1
[9] Parasole R, Izzo F, Perrone F , et al. Prognostic value of serum biological markers in patients with hepatocellular carcinoma[J]. Clin Cancer Res, 2001,7(11):3504-3509
doi: 10.1093/carcin/22.11.1891 pmid: 11705869
[10] Kobayashi R, Yoshimatsu K, Yokomizo H , et al. Low-dose chemotherapy with leucovorin plus 5-fluorouracil for colorectal cancer can maintain host immunity[J]. Anticancer Res, 2007,27(1B):675-679
[11] Jia LQ, Li X, Wan DG , et al. The effectiveness of two-way immune modulation of Jinlong Capsules in SARS patients[J]. Beijing Yi Xue, 2005,27(9):550-552
doi: 10.3969/j.issn.0253-9713.2005.09.013
贾立群, 李学, 万冬桂 , 等. 金龙胶囊的免疫双向调节作用[J]. 北京医学, 2005,27(9):550-552
doi: 10.3969/j.issn.0253-9713.2005.09.013
[12] Qiu FB, Wu LQ, Lu Y , et al. Predominant expression of Th1-type cytokines in primary hepatic cancer and adjacent liver tissues[J]. Hepatobiliary Pancreat Dis Int, 2007,6(1):63-66
[13] Ishiyama K, Ohdan H, Ohira M , et al. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans[J]. Hepatology, 2006,43(2):362-372
doi: 10.1002/(ISSN)1527-3350
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