Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 907-910.doi: 10.3736/jcim20080906

• Original Clinical Research • Previous Articles     Next Articles

Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy

Huo-jun Zhang, Ji-jin Yang(), Wei-xing Wang, Xu Jiang, Yan-jun Mao, Chao-ai Yang, Ji-xiang Guo   

  1. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2008-04-14 Online:2008-09-20 Published:2008-09-15

Objective: To observe and discuss the dynamic changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) and their significance in the patients with primary liver cancer after transarterial chemoembolization (TACE) therapy combined with Jinglong Capsule.
Methods: A total of 48 patients with primary liver cancer, who failed to be treated by major surgery, were randomly divided into two groups: Jinlong Capsule group (TACE therapy plus Jinlong Capsule) and control group (TACE therapy alone). There were 24 cases in each group. The levels of peripheral blood IL-2 and slL-2R were measured before the first TACE and 1, 7 and 15 days after the second TACE respectively by using double-antibody sandwich enzyme-linked immunosorbent assay. The data from Jinlong Capsule group were compared with those from the control group.
Results: The level of sIL-2R in Jinlong Capsule group was significantly lower than that in the control group (P<0.05), while the level of IL-2 was significantly higher than that in the control group (P<0.05).
Conclusion: Jinlong Capsule can significantly improve the lymphocyte function of the patients with primary liver cancer after TACE. The levels of IL-2 and sIL-2R can be considered as the valuable parameters for evaluating the effects on primary liver cancer, and Jinlong Capsule is helpful for the patients with primary liver cancer.

Key words: liver cancer, radiography, interventional, interleukin-2, Jinlong Capsule, randomized controlled trial

CLC Number: 

  • R735.7

Table 1

The serum level of IL-2 at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 490.21±101.33 706.68±135.24 598.38±102.11 668.69±98.11
Jinglong Capsule 24 475.68±95.53 886.79±101.22* 713.45±88.63* 894.75±135.43*
t 0.983 5.374 6.742 8.012

Table 2

The serum level of sIL-2R at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 425.34±101.21 321.19±105.37 397.65±98.54 311.47±103.28
Jinglong Capsule 24 436.11±121.98 273.68±103.12* 302.18±106.44* 255.69±134.26*
t 0.521 5.101 7.214 6.872
[1] El-Shanawani FM, Abdel-Hadi AA, Abu Zikri NB , et al. Clinical significance of aflatoxin, mutant P53 gene and sIL-2 receptor in liver cirrhosis and hepatocellular carcinoma[J]. Egypt Soc Parasitol, 2006,36(1):221-239
[2] Handzel ZT, Barak V, Altman Y , et al. Increased Th1 and Th2 type cytokine production in patients with active tuberculosis[J]. Isr Med Assoc J, 2007,9(6):479-483
doi: 10.1007/s11845-007-0023-0 pmid: 17642401
[3] Sandberg JK, Moll M . Effects of interleukin-2 treatment on CD1d-restricted natural killer T cells[J]. Clin Cancer Res, 2007,13(14):4311-4315
doi: 10.1158/1078-0432.CCR-07-1267 pmid: 17634562
[4] Garrod KR, Wei SH, Parker I , et al. Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets[J]. Proc Natl Acad Sci U S A, 2007,104(29):12081-12086
doi: 10.1073/pnas.0702867104
[5] Porta C, Paglino C, Imarisio I , et al.Cytokine-based immunotherapy for advanced kidney cancer: past results and future perspectives in the era of molecularly targeted agents[J].ScientificWorldJournal, 2007, 7: 837-849
doi: 10.1100/tsw.2007.154
[6] Barker SE, Grosse SM, Siapati EK , et al. Immunotherapy for neuroblastoma using syngeneic fibroblasts transfected with IL-2 and IL-12[J]. Br J Cancer, 2007,97(2):210-217
doi: 10.1038/sj.bjc.6603857 pmid: 2360308
[7] Ottaiano A, Leonardi E, Simeone E , et al. Soluble interleukin-2 receptor in stage I-III melanoma[J]. Cytokine, 2006,33(3):150-155
doi: 10.1016/j.cyto.2006.01.002 pmid: 16517174
[8] Izzo F, Cremona F, Delrio P , et al. Soluble interleukin-2 receptor levels in hepatocellular cancer: a more sensitive marker than alfa fetoprotein[J]. Ann Surg Oncol, 1999,6(2):178-185
doi: 10.1007/s10434-999-0178-1
[9] Parasole R, Izzo F, Perrone F , et al. Prognostic value of serum biological markers in patients with hepatocellular carcinoma[J]. Clin Cancer Res, 2001,7(11):3504-3509
doi: 10.1093/carcin/22.11.1891 pmid: 11705869
[10] Kobayashi R, Yoshimatsu K, Yokomizo H , et al. Low-dose chemotherapy with leucovorin plus 5-fluorouracil for colorectal cancer can maintain host immunity[J]. Anticancer Res, 2007,27(1B):675-679
[11] Jia LQ, Li X, Wan DG , et al. The effectiveness of two-way immune modulation of Jinlong Capsules in SARS patients[J]. Beijing Yi Xue, 2005,27(9):550-552
doi: 10.3969/j.issn.0253-9713.2005.09.013
贾立群, 李学, 万冬桂 , 等. 金龙胶囊的免疫双向调节作用[J]. 北京医学, 2005,27(9):550-552
doi: 10.3969/j.issn.0253-9713.2005.09.013
[12] Qiu FB, Wu LQ, Lu Y , et al. Predominant expression of Th1-type cytokines in primary hepatic cancer and adjacent liver tissues[J]. Hepatobiliary Pancreat Dis Int, 2007,6(1):63-66
[13] Ishiyama K, Ohdan H, Ohira M , et al. Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans[J]. Hepatology, 2006,43(2):362-372
doi: 10.1002/(ISSN)1527-3350
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[3] Xin-yu Yue, Zhuo-qi Feng, Xi-yi Yu, Jia-min Hu, Xiao-Jing He, Shi Shu. Fire-needle acupuncture for upper limb spastic paralysis after stroke: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 167-172.
[4] Ya-ru Huangfu, Wei Peng, Bao-jun Guo, Zhi-fu Shen, Li Li, Shi-wei, Liu, Hui Zheng, You-ping Hu. Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 161-167.
[5] Pádraic J.Dunne, Julie Lynch, Lucia Prihodova, Caoimhe O'Leary, Atiyeh Ghoreyshi, Sharee A. Basdeo, Donal J.Cox, Rachel Breen, Ali Sheikhi, Áine Carroll, Cathal Walsh, Geraldine McMahon, Barry White. Burnout in the emergency department: Randomized controlled trial of an attention-based training program. Journal of Integrative Medicine, 2019, 17(3): 173-180.
[6] J.M. Oliver-Baxter, H.S. Whitford, D.A. Turnbull, M.J. Bond. Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(5): 322-328.
[7] Chang-quan Ling, Jia Fan, Hong-sheng Lin, Feng Shen, Zhen-ye Xu, Li-zhu Lin, Shu-kui Qin, Wei-ping Zhou, Xiao-feng Zhai, Bai Li, Qing-hui Zhou, on behalf of the Chinese Integrative Therapy of Primary Liver Cancer Working Group. Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine. Journal of Integrative Medicine, 2018, 16(4): 236-248.
[8] Parunkul Tungsukruthai, Preecha Nootim, Wiwan Worakunphanich, Nareerat Tabtong. Efficacy and safety of herbal steam bath in allergic rhinitis: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(1): 39-44.
[9] Zahra Hajmohammadi, Mojtaba Heydari, Majid Nimrouzi, Pouya Faridi, Mohammad Javad Zibaeenezhad, Gholamhossein Ranjbar Omrani, Mesbah Shams . Rhus coriaria L. increases serum apolipoprotein-A1 and high-density lipoprotein cholesterol levels: A double-blind placebo-controlled randomized clinical trial. Journal of Integrative Medicine, 2018, 16(1): 45-50.
[10] Laura Belland, Laura Rivera-Reyes, Ula Hwang. Using music to reduce anxiety among older adults in the emergency department: A randomized pilot study. Journal of Integrative Medicine, 2017, 15(6): 450-455.
[11] Hilal Yuksel, Yasemin Cayir, Zahide Kosan, Kenan Tastan. Effectiveness of breathing exercises during the second stage of labor on labor pain and duration: A randomized controlled trial. Journal of Integrative Medicine, 2017, 15(6): 456-461.
[12] Yoshiharu Motoo, Takashi Hakamatsuka, Nobuo Kawahara, Ichiro Arai, Kiichiro Tsutani. Standards of Reporting Kampo Products (STORK) in research articles. Journal of Integrative Medicine, 2017, 15(3): 182-185.
[13] Maria T.Chao, AlexandraChang, SanjayReddy, James D.Harrison, JosephAcquah, MiriaToveg, TrilceSantana, Frederick M.Hecht. Adjunctive acupuncture for pain and symptom management in the inpatient setting: Protocol for a pilot hybrid effectiveness-implementation study. Journal of Integrative Medicine, 2016, 14(3): 228-238.
[14] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[15] Maria Sousa Cláudia, Coimbra Daniela, Machado Jorge, J. Greten Henry. Effects of self-administered exercises based on Tuina techniques on musculoskeletal disorders of professional orchestra musicians: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(5): 314-318.
Full text



[1] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[2] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[3] Ji Chen, Qin Pan, Li-shuang Ye, Jia-ling Huang. English translation of cultural aspects of the titles of traditional Chinese medicine classics based on the skopos theory. Journal of Chinese Integrative Medicine, 2012, 10(11): 1316-1320
[4] Li-ke Guo, Chao-xian Zhang, Xiao-feng Guo. Acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in treatment of functional constipation: A randomized, controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(11): 1206-1214
[5] Yong Miao Edwin. Clinical critical qualitative evaluation of the selected randomized controlled trials in current acupuncture researches for low back pain. Journal of Chinese Integrative Medicine, 2010, 8(12): 1133-1146
[6] Li Tao, Ying-jie Zhu , Xian-mei Lu , Ying Gu , Ai-guang Zhao , Jian Zheng, Chuan-gang Fu, Jin-kun Yang. Clinical study on survival benefit for elderly patients with resected stage I or E colorectal cancer based on traditional Chinese medicine syndrome differentiation and treatment. Journal of Chinese Integrative Medicine, 2010, 8(12): 1159-1164
[7] Yong-mei Liu, Rui-hua Liu, Wen-jun Liu, Li Liu , Zhi-kui Wu, Yu-ying Chen. Effects of Chinese herbal medicine Yiqi Huoxue Formula on TGF-p/smad signal transduction pathway and connective tissue growth factor in rats with renal interstitial fibrosis. Journal of Chinese Integrative Medicine, 2010, 8(12): 1165-1173
[8] Mei-jun Lü, Hui-yong Zhang, Zhe Zhang, Guan-lin Yang. Measurement of health-related quality of life in coronary heart disease: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1277-1285
[9] Xiao-qiang Yue, Xue Yang, Jian Cui. To explore "the relief time" of diseases involving the six meridians in Shang Han Lun in light of the sequence of three yin and three yang. Journal of Chinese Integrative Medicine, 2008, 6(2): 124-127
[10] Li-hui Dang, Xiao-nan Yang, Qing Xia. Protective effects of Chaiqin Chengqi Decoction on isolated pancreatic acinar cells in acute pancreatitis rats and the mechanisms. Journal of Chinese Integrative Medicine, 2008, 6(2): 176-179