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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 907-910.doi: 10.3736/jcim20080906

• Original Clinical Research • Previous Articles     Next Articles

Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver cancer after transarterial chemoembolization therapy

Huo-jun Zhang, Ji-jin Yang(), Wei-xing Wang, Xu Jiang, Yan-jun Mao, Chao-ai Yang, Ji-xiang Guo   

  1. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2008-04-14 Online:2008-09-20 Published:2008-09-15

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Objective: To observe and discuss the dynamic changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (sIL-2R) and their significance in the patients with primary liver cancer after transarterial chemoembolization (TACE) therapy combined with Jinglong Capsule.
Methods: A total of 48 patients with primary liver cancer, who failed to be treated by major surgery, were randomly divided into two groups: Jinlong Capsule group (TACE therapy plus Jinlong Capsule) and control group (TACE therapy alone). There were 24 cases in each group. The levels of peripheral blood IL-2 and slL-2R were measured before the first TACE and 1, 7 and 15 days after the second TACE respectively by using double-antibody sandwich enzyme-linked immunosorbent assay. The data from Jinlong Capsule group were compared with those from the control group.
Results: The level of sIL-2R in Jinlong Capsule group was significantly lower than that in the control group (P<0.05), while the level of IL-2 was significantly higher than that in the control group (P<0.05).
Conclusion: Jinlong Capsule can significantly improve the lymphocyte function of the patients with primary liver cancer after TACE. The levels of IL-2 and sIL-2R can be considered as the valuable parameters for evaluating the effects on primary liver cancer, and Jinlong Capsule is helpful for the patients with primary liver cancer.

Key words: liver cancer, radiography, interventional, interleukin-2, Jinlong Capsule, randomized controlled trial

CLC Number: 

  • R735.7

Table 1

The serum level of IL-2 at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 490.21±101.33 706.68±135.24 598.38±102.11 668.69±98.11
Jinglong Capsule 24 475.68±95.53 886.79±101.22* 713.45±88.63* 894.75±135.43*
t 0.983 5.374 6.742 8.012

Table 2

The serum level of sIL-2R at different treatment time in two groups (x±s, ng/L)"

Group n Before treatment Day 1 Day 7 Day 15
Control 24 425.34±101.21 321.19±105.37 397.65±98.54 311.47±103.28
Jinglong Capsule 24 436.11±121.98 273.68±103.12* 302.18±106.44* 255.69±134.26*
t 0.521 5.101 7.214 6.872
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