用随机行走模型评价生脉注射液治疗冠心病的临床疗效

doi:10.3736/jcim20080905

Abstract

Objective: To evaluate the clinical effects of Shengmai Injection in treating coronary heart disease (CHD) based on correct syndrome differentiation and incorrect syndrome differentiation.
Methods: The patients' information was collected by a system of individual diagnosis and treatment of CHD. The score of main symptoms was calculated and recorded during the treatment. Patients were divided into two groups (incorrect syndrome and correct syndrome groups) on the basis of syndrome differentiation treatment or not. The clinical therapeutic effects of the two treatments were evaluated based on statistic theory combined with random walk method.
Results: There were 273 patients in the correct syndrome group and 4 patients died (case-fatality rate was 1.47%). There were 297 patients in the incorrect syndrome group and 7 patients died (case-fatality rate was 2.36%). In the correct syndrome group, random fluctuation peak of comprehensive evaluation index, walk steps, positive growth rate of walk, ratio, random fluctuation power-law, increase rate and record times of comprehensive evaluation index were 1 472, 13 617, 0.108 1, 9.25, 0.674 2, 0.470 6 and 3 128 respectively, while in the incorrect syndrome group, 1 030, 14 588, 0.070 6, 14.16, 0.660 6, 0.312 8 and 3 293 respectively. The random fluctuation power-law in both groups exceeded 0.5.
Conclusion: There is a long-range correlation between the comprehensive evaluation index and therapeutic method as the CHD patients were treated with Shengmai Injection. The clinical therapeutic effects of Shengmai Injection under correct syndrome differentiation are better than the effects of Shengmai Injection under incorrect syndrome differentiation.

Key words: Shengmai Injection, coronary disease, treatment effectiveness, random walk model

CLC Number:

R541.4

Zhu-ye Gao, Hao Xu, Ke-ji Chen, Da-zhuo Shi, Li-zhi Li, Xue-zhong Zhou. Efficacy evaluation of Shengmai Injection in treating coronary heart disease based on random walk model. Journal of Chinese Integrative Medicine, 2008, 6(9): 902-906.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080905

http://www.jcimjournal.com/EN/Y2008/V6/I9/902

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References 12

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Group	n	Sex (male/female)	Age (x±s, year)	AMI	AP	CA	CHF	DM	HLP	HP	OMI
Incorrect syndrome	297	146/151	69.19±10.95	83	122	82	67	72	32	199	48
Correct syndrome	273	139/134	70.74±9.97	55*	114	99	61	82	29	150	60

Group	n	Shengmai Injection		ASP	ACEI/ARB	CCB	β-receptor blocker	LMH
Group	n	Dosage (x±s, ml/d)	Treatment course (x±s, day)	ASP	ACEI/ARB	CCB	β-receptor blocker	LMH
Incorrect syndrome	297	39.29±16.25	8.44±5.12	249	187	117	205	179
Correct syndrome	273	37.32±14.84	7.81±4.73	254	172	102	193	154

Efficacy evaluation of Shengmai Injection in treating coronary heart disease based on random walk model

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