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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 911-914.

• Original Experimental Research • Previous Articles     Next Articles

Effects of ginsenoside Rg1 on expression of insulin-like growth factor-1 in brain of rats with brain contusion

Wen-kai Li1, Wen-bin Ran2, Ying-wen Su1, Fei-jun Huang1()   

  1. 1. Department of Forensic Pathology, West China College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province 610041, China
    2. Laboratory of Preclinical Medicine, West China College of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province 610041, China
  • Received:2008-01-04 Online:2008-09-20 Published:2008-09-15

Objective: To study the effects of ginsenoside Rg1 on the expression of insulin-like growth factor-1 (IGF-1) in the brain of rats after the experimental brain contusion.
Methods: A total of twenty-six Wistar rats were randomly divided into normal control group (n=2), untreated group (n=8) and ginsenoside Rg1 group (n=16). Brain injuries were induced in rats by a mechanical striking device. The brain tissues were extracted at different times after brain injury (6th hour, 12th hour, 2nd day, 6th day), then the expression of IGF-1 in brain tissue was examined by immunohistochemical method.
Results: In comparison with the normal control group, the expression of IGF-1 in the brain tissues was increased in the untreated group after the brain contusion ( P<0.05). The expression of IGF-1 in brain tissues in ginsenoside Rg1 group was significantly increased as compared with the untreated group ( P<0.05).
Conclusion: Ginsenoside Rg1 enhances the recovery of the contused brain through increasing the expression of IGF-1.

Key words: brain contusion, insulin-like growth factor-1, ginsenoside Rgl, rats

CLC Number: 

  • R285.5

Table 1

Counts of IGF-1 positive cells in brain tissues of rats in different groups (x±s)"

Group n Counts of IGF-1 positive cells
6 hours 12 hours 2 days 6 days
Normal control 2 432±57
Untreated 2 504±36* 904±68 1 269±75 1 619±150
Ginsenoside Rg1 4 571±24 1 060±136 1 449±143 2 587±121

Figure 1

Expression of IGF-1 in brain tissues of rats in untreated group at different times after the brain contusion (SP staining, ×400) A: 6 hours after brain contusion; B: 2 days after brain contusion."

Figure 2

Expression of IGF-1 in brain tissues of rats in ginsenoside Rg1 group at different times after the brain contusion ( SP staining, ×400) A: 6 hours after brain contusion; B: 2 days after brain contusion."

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