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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (11): 1105-1108.doi: 10.3736/jcim20081102

• Original Clinical Research • Previous Articles     Next Articles

Combination and transformation of toxin and blood stasis in etiopatho-genesis of thrombotic cerebrocardiovascular diseases

Da-zhuo Shi1(), Hao Xu2, Hui-jun Yin1, Jing-chun Zhang1, Ke-ji Chen1   

  1. 1. Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    2. National Integrated Center of Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2008-05-12 Online:2008-11-20 Published:2008-11-15

According to the basic theory of traditional Chinese medicine (TCM), the pathogenetic factors such as platelet activation, adhesion, congregation and thrombosis fall into the category of blood stasis, while the pathological changes such as tissue necrosis, oxidative stress injury and inflammation, etc, are far beyond the etiological category of blood stasis. The toxin or the combination and transformation of toxin and blood stasis of TCM are involved in the pathogenesis of thrombotic cerebrocardiovascualr diseases. It is significant to recognize and stress the combination and transformation of toxin and stasis in pathogenicity so as to enrich TCM etiology and improve TCM clinical efficacy in the treatment of cerebrocardiovascular and thrombotic diseases.

Key words: cardiovascular diseases, thrombosis, blood stasis

CLC Number: 

  • R54


致病特点 广泛性、兼夹性、久病入络、久病成瘀 依附性、酷烈性、从化性、秽浊性、兼夹性、顽固性
临床症状 痛有定处、固定性刺痛或绞痛、皮下瘀斑、精神狂躁或健忘、唇及肢端紫绀、唇和齿龈及眼周紫黑、舌下及其他部位静脉曲张等 发病急骤,见症多端,变化迅速,神志昏迷或谵妄、烦躁不安和疼痛剧烈等
舌象 舌质紫暗或舌体瘀斑、瘀点 舌质紫绛或舌苔垢腻、焦燥、起芒刺
脉象 脉涩或结代、无脉 脉浮大或弦滑而数或六脉沉细
微观病理 微循环障碍、血液流变学异常、血小板聚集性增高、血管栓塞、血液凝固性增高或纤溶活性降低等 炎性介质、血管活性物质过度释放、超氧化物释放、自由基和代谢物质堆积、钙离子超载或兴奋性氨基酸神经毒堆积等
[1] Chen KJ, Li LD, Weng WL , et al. Studies of blood stasis syndrome and activating blood circulation[J]. Zhongguo Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2005,3(3):1-2
陈可冀, 李连达, 翁维良 , 等. 血瘀证与活血化瘀研究[J]. 中国中西医结合心脑血管病杂志, 2005,3(3):1-2
[2] Li PT, Wang YY, Huang QF . The hypojournal of the injury of brain collaterals by toxins and its theoretical and practical significance[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2001,24(1):1-6
doi: 10.3321/j.issn:1006-2157.2001.01.002
李澎涛, 王永炎, 黄启福 . “毒损脑络”病机假说的形成及其理论与实践意义[J]. 北京中医药大学学报, 2001,24(1):1-6
doi: 10.3321/j.issn:1006-2157.2001.01.002
[3] Chi MY. Integration of Chinese and Western medicine thrombology[M]. Beijing: People's Medical Publishing House,2004: 1-5
池明宇 . 中西医结合血栓病学[M]. 北京: 人民卫生出版社,2004: 1-5
[4] Wagner DD, Burger PC . Platelets in inflammation and thrombosis[J]. Arterioscler Thromb Vasc Biol, 2003,23(12):2131-2137
doi: 10.1161/01.ATV.0000095974.95122.EC pmid: 14500287
[5] Ruggeri ZM . Platelets in atherothrombosis[J]. Nat Med, 2002,8(11):1227-1234
doi: 10.1038/nm1102-1227
[6] Pearson TA, Mensah GA, Alexander RW , et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association[J]. Circulation, 2003,107(3):499-511
doi: 10.2165/1153161-S0-000000000-00000 pmid: 20000881
[7] Kovanen PT, Kaartinen M, Paavonen T . Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction[J]. Circulation, 1995,92(5):1084-1088
doi: 10.1161/01.CIR.92.5.1084
[8] Feinbloom D, Bauer KA . Assessment of hemostatic risk factors in predicting arterial thrombotic events[J]. Arterioscler Thromb Vasc Biol, 2005,25(10):2043-2053
doi: 10.1161/01.ATV.0000181762.31694.da pmid: 16100033
[9] Li JZ . Attention to arterial thrombotic diseases[J]. Zhonghua Nei Ke Za Zhi, 2006,45(1):2-3
doi: 10.3760/j.issn:0578-1426.2006.01.002
李家增 . 关注动脉血栓栓塞性疾病[J]. 中华内科杂志, 2006,45(1):2-3
doi: 10.3760/j.issn:0578-1426.2006.01.002
[10] Porter TR, Li S, Oster R , et al. The clinical implications of no reflow demonstrated with intravenous perfluorocarbon containing microbubbles following restoration of Thrombolysis In Myocardial Infarction(TIMI) 3 flow in patients with acute myocardial infarction[J]. Am J Cardiol, 1998,82(10):1173-1177
doi: 10.1016/S0002-9149(98)00597-9
[11] Kenner MD, Zajac EJ, Kondos GT , et al. Ability of the no-reflow phenomenon during an acute myocardial infarction to predict left ventricular dysfunction at one-month follow-up[J]. Am J Cardiol, 1995,76(12):861-868
doi: 10.1016/S0002-9149(99)80250-1
[12] Wei JL . Hypojournal on the relationship between toxic heat and apoplexy[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2003,26(1):7-11
魏江磊 . 中风热毒论[J]. 北京中医药大学学报, 2003,26(1):7-11
[13] Lu XH . Clinical effect and mechanism on treating unstable angina pectoris by Huanlian Jiedu Capsule[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2005,29(6):457-460
doi: 10.3969/j.issn.1007-659X.2005.06.020
卢笑辉 . 黄连解毒胶囊治疗不稳定型心绞痛临床疗效及作用机制研究[J]. 山东中医药大学学报, 2005,29(6):457-460
doi: 10.3969/j.issn.1007-659X.2005.06.020
[14] Wen C, Xu H, Huang QF , et al. Effects of herbs of activation blood on atherosclerotic plaque morphology in ApoE gene-deficient mice[J]. Zhongguo Bing Li Sheng Li Za Zhi, 2005,21(8):1640
doi: 10.3321/j.issn:1000-4718.2005.08.071
文川, 徐浩, 黄启福 , 等. 6种活血中药及芎芍胶囊对ApoE基因缺陷小鼠动脉粥样硬化斑块胶原沉积及其代谢的影响[J]. 中国病理生理杂志, 2005,21(8):1640
doi: 10.3321/j.issn:1000-4718.2005.08.071
[15] Wen C, Xu H, Huang QF , et al. Effect of drugs for promoting blood circulation on blood lipids and inflammatory reaction of atherosclerotic plaques in ApoE gene deficiency mice[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005,25(4):345-349
doi: 10.3321/j.issn:1003-5370.2005.04.015
文川, 徐浩, 黄启福 , 等. 活血中药对ApoE基因缺陷小鼠血脂及动脉粥样硬化斑块炎症反应的影响[J]. 中国中西医结合杂志, 2005,25(4):345-349
doi: 10.3321/j.issn:1003-5370.2005.04.015
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