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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (11): 1105-1108.doi: 10.3736/jcim20081102

• Original Clinical Research • Previous Articles     Next Articles

Combination and transformation of toxin and blood stasis in etiopatho-genesis of thrombotic cerebrocardiovascular diseases

Da-zhuo Shi1(), Hao Xu2, Hui-jun Yin1, Jing-chun Zhang1, Ke-ji Chen1   

  1. 1. Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    2. National Integrated Center of Cardiovascular Disease, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2008-05-12 Online:2008-11-20 Published:2008-11-15

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According to the basic theory of traditional Chinese medicine (TCM), the pathogenetic factors such as platelet activation, adhesion, congregation and thrombosis fall into the category of blood stasis, while the pathological changes such as tissue necrosis, oxidative stress injury and inflammation, etc, are far beyond the etiological category of blood stasis. The toxin or the combination and transformation of toxin and blood stasis of TCM are involved in the pathogenesis of thrombotic cerebrocardiovascualr diseases. It is significant to recognize and stress the combination and transformation of toxin and stasis in pathogenicity so as to enrich TCM etiology and improve TCM clinical efficacy in the treatment of cerebrocardiovascular and thrombotic diseases.

Key words: cardiovascular diseases, thrombosis, blood stasis

CLC Number: 

  • R54

"

瘀 毒
致病特点 广泛性、兼夹性、久病入络、久病成瘀 依附性、酷烈性、从化性、秽浊性、兼夹性、顽固性
临床症状 痛有定处、固定性刺痛或绞痛、皮下瘀斑、精神狂躁或健忘、唇及肢端紫绀、唇和齿龈及眼周紫黑、舌下及其他部位静脉曲张等 发病急骤,见症多端,变化迅速,神志昏迷或谵妄、烦躁不安和疼痛剧烈等
舌象 舌质紫暗或舌体瘀斑、瘀点 舌质紫绛或舌苔垢腻、焦燥、起芒刺
脉象 脉涩或结代、无脉 脉浮大或弦滑而数或六脉沉细
微观病理 微循环障碍、血液流变学异常、血小板聚集性增高、血管栓塞、血液凝固性增高或纤溶活性降低等 炎性介质、血管活性物质过度释放、超氧化物释放、自由基和代谢物质堆积、钙离子超载或兴奋性氨基酸神经毒堆积等
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