Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (10): 907-.doi: 10.3736/jcim20091002

• Review • Previous Articles     Next Articles

Methodology and purposes of establishing mouse and rat models for syndrome differentiation and treatment

 Zhao-qin Fang,Zhi-qiang Pan, Wen-li Lu, Xiao-mei Liu, Dong-yuan Guan, Chao Liang   

  1. Basic Theory Subjects of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai 201203, China
  • Received:2009-06-09 Accepted:2009-08-22 Online:2009-10-20 Published:2009-10-15
  • Contact: Zhao-qin Fang E-mail:zqfang@sh163d.sta.net.cn

Methodology of syndrome differentiation and syndrome-based treatment in rats and mice has professional characteristics and caters to the research and development of traditional Chinese medicine (TCM). In this paper, the authors introduced their systematic research in five aspects. 1) Rats and mice can be used to simulate TCM clinical practice. Diagnosis and syndrome differentiation can be done to the rats and mice, and information collected by the four diagnostic methods from the experimental animals meets the requirements of treatment based on syndrome differentiation. 2) Standardized and quantified four diagnostic methods and syndrome differentiation for rats and mice can be established, and are operational and applicable for general use. 3) There exists constitution and syndrome diversity in normal rats and mice. A spontaneous syndrome can develop in diseased rats and mice, and it can be accompanied by or even change to another syndrome, similar to that in human beings. 4) There is a complicated material base for syndromes inferred from the different gene expressions and splices in neuroendocrine-immune network. 5) Individualized treatment based on syndrome differentiation, as well as quantified evaluation and comparison of the treatment efficacy can be done in the rat and mouse models of syndromes. The established methodology and criteria for syndrome differentiation and syndrome-based treatment in rats and mice can be used in the following four research fields: 1) syndrome identification on rat or mouse models; 2) research on the basic theories of TCM, such as the research on the viscera manifestation theory, the material base of syndromes, function mechanisms of the treatment based on syndrome differentiation, and the diagnostics of TCM; 3) study in clinical subject of TCM, such as evaluation and comparison of the efficacy of treatment based on syndrome differentiation, protocol optimization of syndrome differentiation and treatment, and preventive treatment of diseases; 4) study in traditional Chinese drugs, such as the research on properties of Chinese herbal drugs, and pharmacological research on Chinese herbal medicines and formulas

Key words: Rats, Mice, Disease, Symptom complex, Objective four diagnostic methods, Syndrome differentiation, Syndrome differentiation treatment, Drug property

[1] Fang ZQ, Pan ZQ, Lu WL, Liu ZM, Guan DY, Liang C . Research and development on syndromes and methodology of syndromes differentiation and treatment in rats and mice[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(4):12-16
方肇勤, 潘志强, 卢文丽, 刘小美, 管冬元, 梁超 . 大鼠/小鼠证候及辨证论治方法学的探索与发展[J]. 上海中医药大学学报, 2008,22(4):12-16
[2] Fang ZQ, Pan ZQ, Chen X, Lu WL, Fu XL, Hou L . Construction and significance of four diagnostic methodology about experiment mice[J].Shanghai Zhong Yi Yao Za Zhi, 2006, 40(7):1-4, cov3
doi: 10.3969/j.issn.1007-1334.2006.07.001
方肇勤, 潘志强, 陈晓, 卢文丽, 付晓伶, 侯俐 .实验小鼠四诊方法学的创建和意义[J].上海中医药杂志, 2006, 40(7):1-4, 封3
doi: 10.3969/j.issn.1007-1334.2006.07.001
[3] Fang ZQ, Pan ZQ, Lu WL, Liu XM, Hou L , Liao.Establishment and evaluation of metrological methods of syndrome differentiation about common syndrome in rats and mice[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2007,13(7):502-505
方肇勤, 潘志强, 卢文丽, 刘小美, 侯俐, 廖明娟 . 大鼠、小鼠常见证候计量化辨证方法的建立及其评价[J]. 中国中医基础医学杂志, 2007,13(7):502-505
[4] Fang ZQ . Discussion on some basic academic problems in research and development of treatment based on syndrome differentiation.[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2008,28(7):652-655
方肇勤 . 辨证论治研发的一些基本学术问题[J]. 中国中西医结合杂志, 2008,28(7):652-655
[5] Chen X, Chen DS, Fang ZQ . Control study of non-traumatic parameters of syndrome differentiation in tumor-bearing mice[J]. Zhong Yi Za Zhi, 2003,44(1):58-59
doi: 10.3321/j.issn:1001-1668.2003.01.037
陈晓, 陈德溯, 方肇勤 . 荷瘤小鼠非创伤性辨证指标的对照研究[J]. 中医杂志, 2003,44(1):58-59
doi: 10.3321/j.issn:1001-1668.2003.01.037
[6] Pan ZQ, Fang ZQ, Kan WB, Chen X, Fu XL, Wu ZH, Wang SM , Xu.Hind paw atlas and RGB analysis of normal Kunming mice[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2003,17(3):46-48
潘志强, 方肇勤, 阚卫兵, 陈晓, 付晓伶, 吴中华, 王少墨, 许家佗 . 正常昆明种小鼠后爪图谱及RGB分析[J]. 上海中医药大学学报, 2003,17(3):46-48
[7] Pan ZQ, Fang ZQ, Kan WB, Chen X, Fu XL, Wu ZH, Wang SM, Xu JT . Signing atlases of Zheng on hind paws in tumor-bearing mice[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2004,10(2):27-29
doi: 10.3969/j.issn.1006-3250.2004.02.011
潘志强, 方肇勤, 阚卫兵, 陈晓, 付晓伶, 吴中华, 王少墨, 许家 . 荷瘤小鼠后爪部分证的标志图谱[J]. 中国中医基础医学杂志, 2004,10(2):27-29
doi: 10.3969/j.issn.1006-3250.2004.02.011
[8] 8Pan ZQ, Fang ZQ, Fu XL, Kan WB . Evolution of typical syndromes and the characteristics of hind paw images in tumor-bearing mice[J]. Shanghai Zhong Yi Yao Za Zhi, 2004,10(6):F003
doi: 10.3969/j.issn.1007-1334.2004.06.030
潘志强, 方肇勤, 付晓伶, 阚卫兵 . 荷瘤小鼠若干典型证的演变及其后爪图像特征[J]. 上海中医药杂志, 2004,10(6):F003
doi: 10.3969/j.issn.1007-1334.2004.06.030
[9] Pan ZQ, Lu WL, Fang ZQ . Shooting picture of the tongue about mice in microscope[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2007,13(3):189-191
doi: 10.3969/j.issn.1006-3250.2007.03.013
潘志强, 卢文丽, 方肇勤 . 小鼠舌象的显微拍摄[J]. 中国中医基础医学杂志, 2007,13(3):189-191
doi: 10.3969/j.issn.1006-3250.2007.03.013
[10] Lu WL, Fang ZQ, Pan ZQ, Fu XL . Comparison and evaluation of mouse models for four methods of examination in differentiation of eight syndromes such as qi, blood, yin or yang deficiency[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2006,12(6):433-438
doi: 10.3969/j.issn.1006-3250.2006.06.013
卢文丽, 方肇勤, 潘志强, 付晓玲 . 小鼠气、血、阴、阳、虚等八种模型四诊的比较和评价[J]. 中国中医基础医学杂志, 2006,12(6):433-438
doi: 10.3969/j.issn.1006-3250.2006.06.013
[11] Lu WL, Fang ZQ, Pan ZQ, Hou L . Comparison and analysis of qi and blood deficiency syndrome models in four species of mice[J]. Liaoning Zhong Yi Za Zhi, 2007,34(4):519-522
卢文丽, 方肇勤, 潘志强, 侯俐 . 四种不同品系小鼠气虚血虚证候的比较与评价[J]. 辽宁中医杂志, 2007,34(4):519-522
[12] Fang ZQ, Pan ZQ, Fu XL, Lu WL, Chen X, Tang WC, Kan WB, Xu M . The proposal of criterion on mice' four diagnostic methods collecting item[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2005,11(9):692-694
doi: 10.3969/j.issn.1006-3250.2005.09.020
方肇勤, 潘志强, 付晓伶, 卢文丽, 陈晓, 汤伟昌, 阚卫兵, 许敏 . 小鼠四诊采集项目标准的建议[J]. 中国中医基础医学杂志, 2005,11(9):692-694
doi: 10.3969/j.issn.1006-3250.2005.09.020
[13] Fang ZQ, Pan ZQ, Tang WC, Fu XL, Lu WL, Chen X . Construction and operational standard of four diagnostic methods workstation for mice[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2006,20(1):42-46
doi: 10.3969/j.issn.1008-861X.2006.01.015
方肇勤, 潘志强, 汤伟昌, 付晓伶, 卢文丽, 陈晓 . 小鼠“四诊工作站”构建与操作标准探讨[J]. 上海中医药大学学报, 2006,20(1):42-46
doi: 10.3969/j.issn.1008-861X.2006.01.015
[14] Fang ZQ, Pan ZQ, Lu WL, Fu XL, Chen X, Tang WC, Kan WB . Differentiation of symptoms standard of common symptoms in mice[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2006,12(7):508-510
doi: 10.3969/j.issn.1006-3250.2006.07.012
方肇勤, 潘志强, 卢文丽, 付晓伶, 陈晓, 汤伟昌, 阚卫兵, 许敏 . 小鼠常见证候的辨证标准[J]. 中国中医基础医学杂志, 2006,12(7):508-510
doi: 10.3969/j.issn.1006-3250.2006.07.012
[15] Pan ZQ, Fang ZQ, Lu WL . Comparative research on syndrome manifestation features in mice with H22 liver cancer and Lewis lung carcinoma[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2008,31(3):184-188
潘志强, 方肇勤, 卢文丽 . H22肝癌与Lewis肺癌荷瘤小鼠证候特征比较研究[J]. 北京中医药大学学报, 2008,31(3):184-188
[16] Pan ZQ, Fang ZQ, Lu WL . Research of symptoms and signs in nude mice with tumour[J]. Liaoning Zhong Yi Yao Da Xue Xue Bao, 2008,10(9):135-138
doi: 10.3969/j.issn.1673-842X.2008.09.084
潘志强, 方肇勤, 卢文丽 . 荷瘤裸鼠证候特征的研究[J]. 辽宁中医药大学学报, 2008,10(9):135-138
doi: 10.3969/j.issn.1673-842X.2008.09.084
[17] Lu WL, Fang ZQ, Pan ZQ, Hou L, Liu XM . Syndrome characteristics and comparison of six kinds of mice gastrelceosis models[J]. Shanghai Zhong Yi Yao Za Zhi, 2007,41(8):63-68
卢文丽, 方肇勤, 潘志强, 侯俐, 刘小美 . 6种胃溃疡小鼠模型的证候特征及比较[J]. 上海中医药杂志, 2007,41(8):63-68
[18] Lu WL, Fang ZQ, Pan ZQ, Liu XM . Syndrome characteristics and comparison of rat's gastrelceosis models induced by stress or other factors[J]. Fujian Zhong Yi Yao, 2008,39(2):45-48
doi: 10.3969/j.issn.1000-338X.2008.02.027
卢文丽, 方肇勤, 潘志强, 刘小美 . 应激等致大鼠实验性胃溃疡的证候特征及比较[J]. 福建中医药, 2008,39(2):45-48
doi: 10.3969/j.issn.1000-338X.2008.02.027
[19] Liu XM, Fang ZQ, Lu WL, Pan ZQ, Shu S . Characteristic and development of syndrome about diabetes mellitus rats[J]. Liaoning Zhong Yi Za Zhi, 2008,39(2):45-48
刘小美, 方肇勤, 卢文丽, 潘志强, 舒适 . 糖尿病模型大鼠证候的特征及演变[J]. 辽宁中医杂志, 2008,39(2):45-48
[20] Liu XM, Fang ZQ, Pan ZQ, Lu WL, Shu S, Song LN . Comparison between syndromes in hyperlipemia rats fed with two fat-rich diets[J]. Anhui Zhong Yi Xue Yuan Xue Bao, 2008,27(2):33-37
doi: 10.3969/j.issn.1000-2219.2008.02.014
刘小美, 方肇勤, 潘志强, 卢文丽, 舒适, 宋丽娜 . 两种不同配方高脂饲料致高脂血症大鼠的证候比较[J]. 安徽中医学院学报, 2008,27(2):33-37
doi: 10.3969/j.issn.1000-2219.2008.02.014
[21] Lu WL, Fang ZQ, Pan ZQ, Liu XM, Xiao Y, Yuan YL . The syndrome characters and comparison of three kinds of hypertensive rat models[J]. Sichuan Zhong Yi, 2008,26(11):25-28
卢文丽, 方肇勤, 潘志强, 刘小美, 肖芸, 袁雅丽 . SHR、DOCA-盐及肾性高血压大鼠的证候特征及比较[J]. 四川中医, 2008,26(11):25-28
[22] Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF . General characteristics of gene transcription of neuroendocrine and immune tissues of common syndromes in tumor-bearing mice[J]. Shanghai Zhong Yi Yao Za Zhi, 2009,43(1):68-74
方肇勤, 潘志强, 卢文丽, 梁超, 吴中华, 刘小美, 侯俐, 张辉, 卓少元, 廖明娟, 高必峰 . 常见证候荷瘤小鼠神经内分泌免疫组织基因转录的总体特征[J]. 上海中医药杂志, 2009,43(1):68-74
[23] Pan ZQ, Fang ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF . Difference of gene expression in adrenal gland of H22 tumour mice of yang-qi deficiency syndrome and qi-yin-yang deficiency syndrome[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(3):45-50
潘志强, 方肇勤, 卢文丽, 梁超, 吴中华, 刘小美, 侯俐, 张辉, 卓少元, 廖明娟, 高必峰 . 阳气虚和气阴阳虚证荷瘤小鼠肾上腺基因表达的差异性[J]. 上海中医药大学学报, 2008,22(3):45-50
[24] Pan ZQ, Fang ZQ, Lu WL, Liang C, Wu ZH, Liu XM, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF . Differentially expressed genes in adrenal gland of H22 liver cancer mice with different syndromes and in different stages[J]. J Chin Integr Med, 2008,6(8):843-851
潘志强, 方肇勤, 卢文丽, 梁超, 吴中华, 刘小美, 侯俐, 张辉, 卓少元, 廖明娟, 高必峰 . 肝癌小鼠不同阶段有关证候肾上腺差异表达的基因分析[J]. 中西医结合学报, 2008,6(8):843-851
[25] 25Liu XM, Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF . Up- and down-regulated genes in pituitary of tumour mice of poisonous pathogenic factors syndrome and asthenia of qi syndrome[J]. Zhejiang Zhong Xi Yi Jie He Za Zhi, 2008,18(11):664-666
doi: 10.3969/j.issn.1005-4561.2008.11.002
刘小美, 方肇勤, 潘志强, 卢文丽, 梁超, 吴中华, 侯俐, 张辉, 卓少元, 廖明娟, 高必峰 . 邪毒壅盛证和气虚证荷瘤小鼠垂体上调与下调的基因[J]. 浙江中西医结合杂志, 2008,18(11):664-666
doi: 10.3969/j.issn.1005-4561.2008.11.002
[26] Liu XM, Fang ZQ, Pan ZQ, Lu WL, Liang C, Wu ZH, Hou L, Zhang H, Zhuo SY, Liao MJ, Gao BF . Coincident up- or down-regulated genes in pituitary of H22 tumor-bearing mice of different syndromes[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2008,22(4):75-79
刘小美, 方肇勤, 潘志强, 卢文丽, 梁超, 吴中华, 侯俐, 张辉, 卓少元, 廖明娟, 高必峰 . 不同证候H22荷瘤小鼠垂体一致上调或下调的基因[J]. 上海中医药大学学报, 2008,22(4):75-79
[27] Zhuo SY, Fang ZQ, Lu WL, Pan ZQ, Wu ZH, Liang C, Liu XM, Hou L, Zhang H, Liao MJ, Gao BF . Characteristic of gene transcription of tumorous ABC transporter family in H22 tumor-bearing mice with different syndromes[J]. Guangxi Zhong Yi Yao, 2008,31(1):48-53
卓少元, 方肇勤, 卢文丽, 潘志强, 吴中华, 梁超, 刘小美, 侯俐, 张辉, 廖明娟, 高必峰 . 不同证候H22荷瘤小鼠肿瘤ABC转运蛋白家族基因转录特征[J]. 广西中医药, 2008,31(1):48-53
[28] Pan ZQ, Fu XL, Fang ZQ . Further research of syndrome differentiation and treatment in tumor-bearing mice[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2007,13(1):28-31
潘志强, 付晓伶, 方肇勤 . 荷瘤小鼠辨证论治的进一步研究[J]. 中国中医基础医学杂志, 2007,13(1):28-31
[29] Xiao Y, Fang ZQ, Pan ZQ, Lu WL, Yuan YL, Chen BY, Hou L, Liao MJ . Individuation of syndrome differentiation and treatment in H22 tumor-bearing mice[J]. Zhonghua Zhong Yi Yao Xue Kan, 2008,26(7):1486-1488
doi: 10.3969/j.issn.1673-7717.2008.07.049
肖芸, 方肇勤, 潘志强, 卢文丽, 袁亚丽, 陈宝英, 侯俐, 廖明娟 . H22荷瘤小鼠的个体化辨证论治尝试[J]. 中华中医药学刊, 2008,26(7):1486-1488
doi: 10.3969/j.issn.1673-7717.2008.07.049
[30] Fang ZQ, Hou L, Lu WL, Pan ZQ, Liao MJ, Xiao Y . Occurrence, development, accompanying symptoms and prognosis of syndromes in tumor-bearing mice[J]. Shanghai Zhong Yi Yao Za Zhi, 2007,41(1):57-62
doi: 10.3969/j.issn.1007-1334.2007.01.025
方肇勤, 侯俐, 卢文丽, 潘志强, 廖明娟, 肖芸 . 荷瘤小鼠证候的发生、演变、兼证及预后[J]. 上海中医药杂志, 2007,41(1):57-62
doi: 10.3969/j.issn.1007-1334.2007.01.025
[31] Fang ZQ, Pan ZQ, Lu WL . Establishment and development of evaluation platform for medicine nature of Chinese herbs[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2008,14(8):629-631
doi: 10.3969/j.issn.1006-3250.2008.08.029
方肇勤, 潘志强, 卢文丽 . 建立和发展中药药性评价平台[J]. 中国中医基础医学杂志, 2008,14(8):629-631
doi: 10.3969/j.issn.1006-3250.2008.08.029
[1] Brody Slostad, Tejinder Khalsa, Kathleen Young, Hildalicia Guerra, Anjali Bhagra. A case-based approach to integrative medicine for cardiovascular disease prevention. Journal of Integrative Medicine, 2020, 18(2): 159-162.
[2] Noriko Shinjyo, James Parkinson, Jimmy Bell, Tatsuro Katsuno, Annie Bligh. Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Journal of Integrative Medicine, 2020, 18(2): 125-151.
[3] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[4] Maryam Naeimia, Narjes Gorjib, Zahra Memarianib, Reihaneh Moeinib, Mohammad Kamalinejadc, Fatemeh Kolangid. Gastroprotective herbs for headache management in Persian medicine: A comprehensive review. Journal of Integrative Medicine, 2020, 18(1): 1-13.
[5] Yi Ran Hu, San Li Xing, Chuan Chen, Ding Zhu Shen, Jiu Lin Chen. Tiaoxin Recipe, a Chinese herbal formula, inhibits microRNA-34a expression in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Journal of Integrative Medicine, 2019, 17(6): 404-409.
[6] Zienab Mahmoudpour, Javad Shokri, Mohammad Kamalinejad, Neda Meftah, Soraya Khafri, Seyyed Ali Mozaffarpur, Hoda Shirafkan. The efficacy of a Persian herbal formulation on functional bloating: A double-blind randomized controlled trial. Journal of Integrative Medicine, 2019, 17(5): 344-350.
[7] Mohammad Ansaripour, Mohsen Naseri, Mohammad Mahdi Esfahani, Iraj Nabipour, Fatemeh Rakhshani, Arman Zargaran, Roya Kelishadi. Periconceptional care and offspring health at birth and long term, from the perspective of Avicenna. Journal of Integrative Medicine, 2019, 17(2): 80-86.
[8] Xin-fang Zhang, Shui-ying Xiang, Wen-ye Geng, Wen-juan Cong, Jing Lu, Chuan-wei Jiang, Kun Wang, Zi-bing Liu . Electro-acupuncture regulates the cholinergic anti-inflammatory pathway in a rat model of chronic obstructive pulmonary disease. Journal of Integrative Medicine, 2018, 16(6): 418-426.
[9] Morufu Eyitayo Balogun, Elizabeth Enohnyaket Besong, Jacinta Nkechi Obimma, Ogochukwu Sophia Mbamalu, Fankou Serges Athanase Djobissie. Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury. Journal of Integrative Medicine, 2018, 16(5): 342-349.
[10] Lucky Legbosi Nwidu, Raphael Ellis Teme. Hot aqueous leaf extract of Lasianthera africana (Icacinaceae) attenuates rifampicin-isoniazid-induced hepatotoxicity. Journal of Integrative Medicine, 2018, 16(4): 263-272.
[11] Xu-xia Bao, Hui-han Ma, Hao Ding, Wen-wei Li, Min Zhu . Preliminary optimization of a Chinese herbal medicine formula based on the neuroprotective effects in a rat model of rotenone-induced Parkinson’s disease. Journal of Integrative Medicine, 2018, 16(4): 290-296.
[12] Shahnaz Karkon Varnosfaderani, Fataneh Hashem-Dabaghian, Gholamreza Amin, Mahbubeh Bozorgi, Ghazaleh Heydarirad, Esmaeil Nazem, Mohsen Nasiri Toosi, Seyed Hamdollah Mosavat. Efficacy and safety of Amla (Phyllanthus emblica L.) in non-erosive reflux disease: A double-blind, randomized, placebo-controlled clinical trial. Journal of Integrative Medicine, 2018, 16(2): 126-131.
[13] Chun-song Hu, Tengiz Tkebuchava. SEEDi1.0-3.0 strategies for major noncommunicable diseases in China. Journal of Integrative Medicine, 2017, 15(4): 265-269.
[14] Umesh Chandra Dash, Atish Kumar Sahoo. In vitro antioxidant assessment and a rapid HPTLC bioautographic method for the detection of anticholinesterase inhibitory activity of Geophila repens. Journal of Integrative Medicine, 2017, 15(3): 231-241.
[15] Nevin Lianwen Zhang, Chen Fu, Teng Fei Liu, Bao-xin Chen, Kin Man Poon, Pei Xian Chen, Yunling Zhang. A data-driven method for syndrome type identification and classification in traditional Chinese medicine. Journal of Integrative Medicine, 2017, 15(2): 110-123.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[4] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[5] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[6] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[7] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[8] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[9] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[10] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100