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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (1): 15-21.doi: 10.3736/jcim20110104

• Methodology • Previous Articles     Next Articles

Mathematical analysis of characteristics of glucocorticoid-induced yang deficiency or yin deficiency syndrome in animal models based on information entropy theory

Rui Jin1, Bing Zhang1(), Sen-mao Liu2, Li Ni1, Min  Li1, Lian-zhen Li1   

  1. 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
    2. School of Mathematical Sciences, Peking University, Beijing 101871, China
  • Received:2010-05-18 Accepted:2010-06-16 Online:2011-01-20 Published:2011-01-15
  • Contact: Zhang Bing

Objective: Based on information entropy theory, this study analyzes the experimental indicators of glucocorticoid-induced traditional Chinese medicine yang deficiency or yin deficiency syndrome in animal models, thus laying the foundation of defining and interpreting the model state.
Methods: Data of biochemical indicators from 24 groups of animal models with different modeling conditions (type of modeling agent, dosage of modeling agent and modeling time) were collected. Information gain values for three study objects (type of modeling agent, dosage of modeling agent and modeling time) were calculated respectively after standardization, and then characteristics of yang deficiency or yin deficiency syndrome models were interpreted with these values and ranking map.
Results: Greatest information gain values of most indicators were got when the study object was the type of modeling agent, which is the most important factor in the differentiation of model state. With this study object, triglyceride (TG), total cholesterol (TC), total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and corticosteroid (CS) got larger information gain values than testosterone (T), lactic dehydrogenase (LDH), and cyclic adenosine monophosphate (cAMP). This indicated that the former seven indicators may be significantly different between the two animal models induced by hydrocortisone and dexamethasone, respectively. In the study of the modeling time, AST may be affected more than others. In the study of the dosage of modeling agent, TC and ALB may be affected more in the model of hydrocortisone and no indicators were significantly affected by the dosage of modeling agent in the dexamethasone model.
Conclusion: Mathematical method based on information entropy theory allows researchers to analyze experimental data in several experiments at the same time and to interpret the trend and stability of indicators. Based on this study and by analyzing the impacts of different modeling conditions on the indicators, elucidations of the characteristics of glucocorticoid-induced yang deficiency or yin deficiency syndrome in animal models and some biochemical indicators for model comparison are in need.

Key words: information entropy, glucocorticoids, yang deficiency, yin deficiency, models, animal, mathematical computing

[1] Ni L, Zhang B . Re-recognition of animal model of both yin and yang deficiency induced by glucocorticoid[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2009,32(5):327-330
倪莉, 张冰 . 糖皮质激素诱导阴虚阳虚状态动物模型的再认识[J]. 北京中医药大学学报, 2009,32(5):327-330
[2] Lu WL, Fang ZQ . Appraisaal of the modeling methods of yang-deficiency syndrome in animals[J]. Shanghai Zhong Yi Yao Da Xue Xue Bao, 2004,18(4):44-48
卢文丽, 方肇勤 . 阳虚证动物模型的造模方法与评析[J]. 上海中医药大学学报, 2004,18(4):44-48
[3] Bernstein S, Bernstein R. Elements of statistics Ⅰ: Descriptive statistics and probability. Translated by Shi DJ[M]. Beijing: Science Press, 2002: 138
S. 伯恩斯坦, R.伯恩斯坦著.统计学原理(上册)——描述性统计学与概率. 史道济译[M]. 北京: 科学出版社, 2002: 138
[4] Fu ZY. Informatics: basic theory and applications[M]. Beijing: Publishing House of Electronics Industry, 2008: 2, 24
傅祖芸 . 信息论——基础理论与应用[M]. 北京: 电子工业出版社, 2008: 2, 24
[5] Zhang D, Jin BR . Application of information entropy in modern biomedicine[J]. Shu Li Yi Yao Xue Za Zhi, 2001,14(1):74-75
张岱, 金宝荣 . 信息熵在现代生物医学中的应用[J]. 数理医药学杂志, 2001,14(1):74-75
[6] Zhang L, Gong ZL, Chen Y, Gu SD. Data mining of biomedical data[M]. Shanghai: Shanghai Scientific and Technical Publishers, 2008: 87-89
章鲁, 龚著琳, 陈瑛, 顾顺德 . 生物医学数据挖掘[M]. 上海: 上海科学技术出版社, 2008: 87-89
[7] Liang MX, Liu J, Hong ZP, Xu YY. Confusions and strategies of research in traditional Chinese medicine syndrome[M]. Beijing: People’s Medical Publishing House, 1998: 22-23
梁茂新, 刘进, 洪治平, 徐月英 . 中医证研究的困惑与对策[M]. 北京: 人民卫生出版社, 1998: 22-23
[8] Chen SS . Reviews of objective study of yin deficiency and yang deficiency syndromes[J]. Liaoning Zhong Yi Za Zhi, 1994,21(9):429-430
陈树森 . 阴虚阳虚证的客观化研究述评[J]. 辽宁中医杂志, 1994,21(9):429-430
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