Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (3): 257-274.doi: 10.3736/jcim20110306

• Systematic Review • Previous Articles     Next Articles

Systematic review and meta-analysis of randomized controlled trials of Chinese herbal medicine in the treatment of Sjogren's syndrome

 Hui Luo, Mei Han, Jian-ping Liu()   

  1. Center for Evidence-based Medicine,Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2010-11-20 Accepted:2010-12-10 Online:2011-03-20 Published:2011-03-15
  • Contact: Liu Jian-ping E-mail:jianping_l@hotmail.com

Background: Chinese herbal medicine (CHM) has been widely used in the treatment of Sjogren's syndrome. However, there remains no systematic review to assess the effectiveness and safety of CHM.
Objective: To assess the effectiveness and safety of CHM in the treatment of Sjogren's syndrome.
Search strategy: Literature was searched from PubMed, the Cochrane Library (Issue 3, 2010), the China National Knowledge Infrastructure Database, the Chongqing VIP Chinese Science and Technology Periodical Database, the Chinese Biomedical Literature Database (SinoMed), Wanfang Data and the Traditional Chinese Medical Periodical Literature Database. The time limitation ran from the commencement of each database to October 15, 2010.
Inclusion criteria: Randomized controlled trials (RCTs) testing CHM alone or in combination with Western medicine (WM) against WM or placebo used alone were included.
Data extraction and analysis: Two authors collected data independently. The assessment of methodological quality was based on the Cochrane handbook and the data were analyzed by using RevMan 5.0.17 software. Heterogeneity of the included studies was tested and use of statistical model was based on the heterogeneity. The efficacy measure was relative risk (RR) or mean difference with a 95% confidence interval (CI).
Results: A total of 52 RCTs involving 3 886 patients were included. The included trials were all of low quality. CHM was superior in improving clinical symptoms to WM, with statistical significance between the groups (RR: 1.36; 95% CI: 1.24–1.49); CHM plus WM was better than WM used alone (RR: 1.38; 95% CI: 1.30–1.46). CHM improved lacrimal gland function more effectively than WM, with statistical significance between the groups (RR: 2.12; 95% CI: 1.06–3.18); CHM plus WM was better than WM used alone (RR: 1.90; 95% CI: 0.99–2.81). CHM was superior to WM in the improvement of erythrocyte sedimentation rate (RR: –9.63; 95% CI: –15.73––3.52), and CHM plus WM was also more effective than WM used alone (RR: –8.42; 95% CI: –14.71––2.13). However, there was no statistical difference between groups in other immune index (C-reactive protein, rheumatoid factor, IgG, IgA and IgM). The reported adverse effects of CHM were mainly gastrointestinal symptoms, such as diarrhea. The incidence of adverse effects of WM was higher than that of CHM.
Conclusion: CHM appears to improve the symptoms of Sjogren's syndrome. However, due to the low quality of included studies, further well-designed multicenter and large-scale RCTs are still needed to evaluate the beneficial effects of CHM.

Key words: drugs,Chinese herbal, Sjogren's syndrome, meta-analysis, randomized controlled trials

Figure 1

Flow diagram of literature searching and screening of Chinese herbal medicine in the treatment of Sj ?gren’s syndrome CNKI: China National Knowledge Infrastructure Databases; VIP: Chongqing VIP Chinese Science and Technology Periodical Database; CBM: Chinese Biomedical Literature Database (SinoMed); TCM Online: Traditional Chinese Medical Periodical Literature Database; RCTs: randomized controlled trials."

Table 1

Characteristics of included studies"

Study Diagnosis Sample
size
Age
(years)
Gender
(male/female)
Interventions Control Duration
(months)
Follow-up Outcome measure
Zheng 2010[10] 2002 International
criteria[62]
60 38.0 Female Runzao formula and
control intervention
Prednisone, methotrexate and
symptomatic support
3 No Effective rate, amount of tear secretion,
salivary flow rate, GB, CRP, RF and
adverse effect
Yin 2010[11] 2002 International
criteria[62]
40 49.0 Female Yangyin Qingre Jiedu
decoction
Prednisone 1 No Effective rate, symptom score, Amount of
tear secretion, WBC, RF, ESR and
adverse effect
Liu 2010[12] 2002 International
criteria[62]
132 Median
(male/
female):
42/40
57/75 Yuquan pill, Shengmai
injection and control
intervention
Muscarinic receptor agonist,
prednisone, triptergium wilfordii
polyglycosidum, cyclophosphamide and symptomatic support
1 No Effective rate and adverse effect
Li 2010[13] Self-made criteria 240 41.0 86/154 Qingre Quyu decoction
and control intervention
Symptomatic support 6 No Effective rate
Huang 2010[14] 2002 International
criteria[62]
61 59.1 7/54 Shenmai injection and
control intervention
Anethol trithlone tablets 0.5 No Effective rate, amount of tear secretion, salivary flow rate and adverse effect
Hu 2010[15] 2002 International
criteria[62]
64 46.2 Female Ziyin Yangxue Qingre
formula and control
intervention
Hydroxychloroquine sulfate
tablets
3 No Effective rate, symptom score, amount of tear secretion, salivary flow rate, sugar-melt test, CRP, ESR, IgG, IgA, IgM and
adverse effect
Zhang 2009[16] 2002 International
criteria[62]
100 40.6 6/89 Jinju Qingrun capsule,
placebo of prednisone and symptomatic support
Prednisone, placebo of Jinju
Qingrun capsule and symptomatic support
3 No Effective rate, symptom score, amount of tear secretion, salivary flow rate, ESR, IgG, IgA, IgM, γ-globulin and adverse effect
Yang 2009[17] Unclear 168 53.7 33/135 Yangyin Shengjin Qingre Tongluo formula and
prednisone
Prednisone and cyclophosphamide 3 to 6 No Effective rate
Wang 2009[18] 2002 International
criteria[62]
50 45 to 78 5/45 Xuefu Zhuyu oral liquid and control intervention Transfer factor oral liquid 3 No Effective rate
Wang WP
2009[19]
1992 Europe[63] 60 58.0 6/54 Yangyin Jianpi Huoxue
decoction, methotrexatum
and hydroxychloroquine
Methotrexatum, hydroxychloroquine and brombexine 3 No Scores of symptoms and signs, ESR and CRP
Wan 2009[20] Dong 1996[64] 60 28 to 73 7/53 Quzao decoction and
control intervention
Brombexine and symptomatic
support
2 No Effective rate
Su 2009[21] 1992 Europe[63] 60 Median:
53.1
2/58 Yangyin Huoxue Shengjin formula and control
intervention
Hydroprednisone and methotrexate 6 No Effective rate, symptom score, amount of tear secretion, sugar-melt test, ESR,
IgG, IgA, IgM and T lymphocyte
subpopulation
Mao 2009[22] 2002 International
criteria[62]
100 45 to 75 10/90 Xuefu Zhuyu oral liquid
and control intervention
Transfer factor capsule and
symptomatic support
3 No Effective rate and adverse effect
Lu 2009[23] 2002 International
criteria[62]and TCM diagnosis[8]
58 42.6 4/54 Shengjin granules Hydroxychloroquine 3 No Effective rate, symptom score, salivary flow rate, amount of tear secretion, ESR, CRP, TNF-α, ICAM-1, IgG, IgA, IgM and adverse effect
Lian 2009[24] 2002 International
criteria[62]and TCM diagnosis[8]
40 52.1 Female Shengjin Runzao granules Placebo 1.5 No Effective rate, improvement of symptoms and signs, ESR, IgG, RF and adverse
effect
Huang 2009[25] 2002 International
criteria[62]
58 29 to 68 5/53 Yiqi Yangyin Huoxue
formula and control
intervention
Anethol trithlone tablets 1 No Effective rate and adverse effect
Gao 2009[26] 2002 International
criteria[62]
126 30 to 78 11/115 Xuefu Zhuyu oral liquid
and control intervention
Transfer factor capsule and
symptomatic support
3 No Effective rate
Zhong 2008[27] 2002 International
criteria[62]
256 37.0 26/230 Chaihu Tongluo capsule, placebo of prednisone and methotrexate Prednisone acetate, methotrex
ate and placebo of Chaihu
Tongluo capsule
3 No Effective rate, salivary flow rate, amount of tear secretion, ESR, CRP, A/G, Tb, IgG, IgA, IgM and adverse effect
Feng 2008[28] 2002 International
criteria[62]
78 47.4 Female Total glycosides of paeony
and control intervention
Methotrexate 9 Yes Effective rate, amount of tear secretion, sugar-melt test, ESR, γ-globulin and
adverse effect
Lü 2008[29]
2002 International
criteria[62]
124
43.6
16/108
Jinyuan decoction
Brombexine and symptomatic
support
3 No
Effective rate, T lymphocytes (NK cells, CD3, CD4, CD8), IgG, IgA, IgM and
adverse effect
Jin 2008[30] 2002 International
criteria[62]
47 45.0 5/42 Zengye Runzao decoction Hydroxychloroquine, vitamin C,
B and E, and symptomatic support
2 No Effective rate and improvement of
symptoms
Han 2008[31] 2002 International
criteria[62]
58 32.6 5/53 Xuanfei Bujin particle Brombexine 3 No Effective rate, amount of tear secretion, corneal staining test, BUT test, β2-M,
sICAM-1,sIL-2R, ESR, IgG, IgA, IgM and improvement of symptoms
Chen 2008[32] 1992 Europe[63] 52 57.5 6/46 Yiqi Shengjin powder Mucosolvan and symptomatic
support
Unclear No Effective rate, ESR, IgG, IgA, IgM and improvement of symptoms
Wu 2007[33] Guidelines of
China[1]
42 55.0 8/34 Maiwei Dihuang decoction and control intervention Brombexine, thymopeptide and
symptomatic support
2 No Effective rate and improvement of
symptoms
Yan 2007[34] Unclear 56 Median
(male/
female):
55.2/53.6
6/50 Jiawei Shengmai drink
and control intervention
symptomatic support 4 No Effective
rate
Sun 2007[35] 2002 International
criteria[62]
124 44.9 16/108 Qingli Shutong formula
and control intervention
Brombexine and symptomatic
support
3 No Effective rate and salivary flow rate
Shen 2007[36] Unclear 20 60 to 70 Female Hydrocortisone injection
and compound glycyrrhizin
injection
Hydrocortisone injection and
diammonium glycyrrhizinate
injection
2 to 3 Yes Effective rate and adverse effect
Mao 2007[37] 1992 Europe[63] 40 53.1 4/36 Yiqi Jianpi decoction Prednisone 3 No Effective rate, symptom score, amount of tear secretion, salivary flow rate, sugar-melt test, ESR, CRP and RF
Li 2007[38] 2002 International
criteria[62]
68 47.3 7/61 Compound glycyrrhizin
injection and control
intervention
Hydroxychloroquine, brombexine
and symptomatic support
1 No Effective rate, amount of tear secretion, tear break-up time, salary flow rate, β2-M, ESR, RF, IgA, IgG, IgM and adverse effect
Zhou 2006[39] 2002 International
criteria[62]
60 Median
(male/
female):
50/46.25
5/55 Qingzao Jiedu Yangyin
Runzao formula
Prednisone and symptomatic
support
3 No Effective rate, amount of tear secretion, salivary flow rate, sugar-melt test, IgG
and adverse effect
Zhou DH
2006[40]
2002 International
criteria[62]
45 55.0 11/34 Dandi Qiongyu granules
and control intervention
Brombexine, anethol trithione,
thymopeptide and symptomatic
support
2 No Effective rate and symptom score
Wu 2006[41] 2002 International
criteria[62]
62 44.9 8/54 Yiqi Yangyin Quyu formula
and control intervention
Prednisone, methotrexate and
symptomatic support
3 No Effective rate, IgG, IgA, IgM, NK cells, CD3, CD4 and CD8
Shen 2006[42] Zhang 1999[65] 60 52.8 4/56 Runzao oral liquid and
control intervention
Bromhexine and symptomatic
support
3 Yes Effective rate, amount of tear secretion, salivary flow rate, sugar-melt test, rose
bengal staining test, foci lymphocyte
infiltrates, ESR, RF, γ-globulin, anti-SSA antibody, anti-SSB antibody, antinuclear antibody and adverse effect
Niu 2006[43] 1992 Europe[63] 40 33.4 1/39 Jianpi Huashi Qingre
formula and control
intervention
Prednisone and symptomatic
support
1 No Effective rate, ESR, CRP, IgG, IgA,
IgM and improvement of symptoms and adverse effect
Chen 2006[44] 1992 Europe[63] 60 52.8 5/55 Suangan Shengjin formula 1 and 2 Prednisone 6 No Effective rate, RF and ESR
Yang 2005[45] Zhang 1999[65] 84 41.5 3/81 Yangyin Shengjin formula and acupuncture Methotrexate 3 No Effective rate, amount of tear secretion, salivary flow rate, ESR, CRP and IgG
Si 2005[46] TCM diagnosis of
SATCM[66]
58 Unclear Unclear Runzao Tuiyi Mingmu
decoction and auricular-plaster therapy
Prednisone and symptomatic
support
1 to 3 No Effective rate
Liu 2005[47] 2002 International
criteria[62]
60 Median
(male/
female):
48.5/48.0
5/55 Qingzao formula Prednisone 3 No Effective rate, improvement of symptoms, amount of tear secretion, salivary flow
rate, ESR, CRP and adverse effect
Zhao 2003[48] Dong 1996[64] 60 Median
(male/
female):
48/44
2/58 Qiju Dihuang decoction Hydroxychloroquine and
symptomatic support
Unclear No Effective rate and adverse effect
Qian 2003[49] Unclear 72 Unclear 5/67 Jinxueyuan granules Brombexine 3 No Effective rate, improvement of symptoms, sugar-melt test, amount of tear secretion and ESR
Zhong 2003[50] Lu 1987[67] 186 30.7 41/145 Ziyang Shengxue decoction Prednisone and symptomatic
support
3 to 6 No Effective rate, salivary flow rate, amount of tear secretion, WBC, RBC, HB and PLT
Li 2002[51] Dong 1996[64] 60 35 to 59 6/54 Shengmai injection and
control intervention
Symptomatic support 0.5 No Amount of tear secretion, salivary flow
rate and adverse effect
Wu 2002[52] Dong 1996[64] 40 Median:
56
4/36 Ziyin Huoxue formula and control intervention Thymosin and symptomatic
support
2 No Effective rate, salivary flow rate and
amount of tear secretion
Cui 2002[53] Unclear 50 25 to 56 6/44 Runfei Huatan Tongluo
formula
Tripterygiitotorum tablets and
symptomatic support
Unclear No Effective rate
Shen 2002[54] Zhang 1999[65] 60 52.9 5/55 Liuwei Dihuang decoction,
Zengye decoction and
symptomatic support
Bromhexine and symptomatic
support
6 Yes Effective rate, salivary flow rate, amount of tear secretion, sugar-melt test, tear break-up time, rose bengal staining test, lymphocytes infiltration of alabial gland, RF, ESR, anti-SSA antibody, anti-SSB antibody, antinuclear antibody and adverse effect
Hu 2001[55] Manthorpe 1981[68] 150 43.9 23/127 Zengye mixture formula Brombexine and thymopeptide 6 No Effective rate, symptom improvement,
amount of tear secretion, sugar-melt test, FL, ESR, ANA, RF, IgG, IgA and IgM
Wang 2000[56] 1992 Europe[63] 40 50.4 5/35 Runzao mixture formula Levamisole and symptomatic
support
Unclear No Effective rate
Feng 2000[57] Dong 1996[64] 44 34 to 65 1/43 Shengjin Runzao granules Symptomatic support 1 No Salivary flow rate
Chen 2000[58] Unclear 38 48.5 3/35 Qingzao Jiufei decoction and Dahuang Zhechong
pill
Levamisole and symptomatic
support
1 No Effective rate
Liao 1999[59] 1992 Europe[63] 43 50.8 A:5/27;
B: unclear
Mendong Qingfei drink Brombexine and symptomatic
support
1 No Effective rate
Yang 1998[60] Unclear 22 25 to 50 5/17 Qingkailing injection and
compound Danshen
injection
Prednisone, thymopeptide and
symptomatic support
3 No Symptom improvement
Zhou 1997[61] Unclear
50 52.0
12/38
Qiju Dihuang pill or
Huanglian Shangqing pill or Maiwei Dihuang pill or Shihu Yeguang pill, fresh decoction of phragmites, glycyrrhiza and acupuncture
Pilocarpine and symptomatic
support
Unclear
No
Effective rate

"

"

"

Figure 2

Clinical symptom improvement in RCTs of CHM for Sj?gren’s syndrome: a funnel plot analysis (CHM+WM vs WM) The asymmetry of the funnel plot predicted that there were publication bias and other biases in the included RCTs of CHM for Sjgren’s syndrome. RCTs: randomized controlled trials; CHM: Chinese herbal medicine; WM: Western medicine."

[1] Chinese Rheumatology Association . Guidelines for the diagnosis and treatment of Sjogren's syndrome(draft)[J]. Zhonghua Feng Shi Bing Xue Za Zhi, 2003,7(7):446-448
中华医学会风湿病学分会. 干燥综合征诊治指南(草案)[J]. 中华风湿病学杂志, 2003,7(7):446-448
[2] Forsblad-d’Elia H, Carlsten H, Labrie F, Konttinen YT, Ohlsson C . Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations[J]. J Clin Endocrinol Metab, 2009,94(6):2044-2051
doi: 10.1210/jc.2009-0106
[3] Boström EA, d’Elia HF, Dahlgren U, Simark-Mattsson C, Hasséus B, Carlsten H, Tarkowski A, Bokarewa M . Salivary resistin reflects local inflammation in Sjogren's syndrome[J]. J Rheumatol, 2008,35(10):2005-2011
doi: 10.1016/j.wear.2009.01.009 pmid: 18709689
[4] Thomas E, Hay EM, Hajeer A, Silman AJ . Sjogren's syndrome: a community-based study of prevalence and impact[J]. Br J Rheumatol, 1998,37(10):1069-1076
doi: 10.1093/rheumatology/37.10.1069 pmid: 9825745
[5] Alamanos Y, Tsifetaki N, Voulgari PV, Venetsanopoulou AI, Siozos C, Drosos AA . Epidemiology of primary Sjogren's syndrome in north-west Greece, 1982—2003[J]. Rheumatology (Oxford), 2006,45(2):187-191
doi: 10.1093/rheumatology/kei107 pmid: 16332955
[6] Tomsic M, Logar D, Grmek M, Perkovic T, Kveder T . Prevalence of Sjogren's syndrome in Slovenia[J]. Rheumatology (Oxford), 1999,38(2):164-170
doi: 10.1007/s00134-014-3382-9 pmid: 10342631
[7] Zhang NZ, Shi CS, Yao QP, Pan GX, Wang LL, Wen ZX, Li XC, Dong Y . Prevalence of primary Sjogren's syndrome in China[J]. J Rheumatol, 1995,22(4):659-661
pmid: 7791159
[8] Lu ZZ, Jiao SD. Practical traditional Chinese medicine rheumatology[M]. Beijing: People’s Medical Publishing House, 1996: 491
路志正, 焦树德 . 实用中医风湿病学[M]. 北京: 人民卫生出版社, 1996: 491
[9] Higgins JPT , Green S, the Cochrane Collaboration. Cochrane handbook for systematic reviews of interventions. Version 5.0.2. .
[10] Zheng HX, Tao XJ, Yu JN . Clinical observation on Runzao formula in treating 30 cases of primary Sjogren's syndrome[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2010,30(7):436-438
郑红霞, 陶筱娟, 于健宁 . 润燥方辅助治疗原发性干燥综合征30例临床观察[J]. 中国中西医结合杂志, 2010,30(7):436-438
[11] Yin GF, Yue M, Liu FH, Nie JP . Yangyin Qingre Jiedu decoction in treating 20 cases of Sjogren's syndrome[J]. Zhong Yi Yan Jiu, 2010,23(2):40-42
doi: 10.3969/j.issn.1001-6910.2010.02.017
尹国富, 岳敏, 刘福华, 聂建平 . 养阴清热解毒汤治疗干燥综合征20例[J]. 中医研究, 2010,23(2):40-42
doi: 10.3969/j.issn.1001-6910.2010.02.017
[12] Liu HW, Wang X . Yuquan pill in combination with Shengmai injection in the treatment of 67 cases of Sjogren's syndrome[J]. Zhongguo Zhong Yi Yao Zi Xun, 2010,2(1):72
刘恒玮, 王霄 . 玉泉丸联合生脉注射液辅助治疗干燥综合征67例[J]. 中国中医药咨讯, 2010,2(1):72
[13] Li J, Si CQ, Li Q . Clinical observation on Qingre Quyu decoction in the treatment of primary Sjogren's syndrome[J]. Yi Xue Li Lun Yu Shi Jian, 2010,23(5):561
doi: 10.3969/j.issn.1001-7585.2010.05.046
李杰, 司呈秋, 李强 . 清热祛瘀汤治疗原发性干燥综合征的临床观察[J]. 医学理论与实践, 2010,23(5):561
doi: 10.3969/j.issn.1001-7585.2010.05.046
[14] Huang XJ, Xu GH, Li LM, Cui EC . Clinical observation of Shenmai injection in treatment of primary Sjogren's syndrome[J]. Zhongguo Yao Fang, 2010,21(8):724-725
黄晓娟, 徐桂华, 李连茂, 崔恩臣 . 参麦注射液治疗原发性干燥综合征的疗效观察[J]. 中国药房, 2010,21(8):724-725
[15] Hu JG, Chen XJ, Gu JH, Mao JC . Therapeutic effect of Ziyin Yangxue Qingre formula on Sjogren's syndrome: a clinical observation on 33 cases[J]. Zhong Yi Za Zhi, 2010,51(3):226-228
胡建国, 陈湘君, 顾军花, 茅建春 . 滋阴养血清热方联合硫酸羟氯喹片治疗原发性干燥综合征33例临床观察[J]. 中医杂志, 2010,51(3):226-228
[16] Zhang SY, Li R, Zhu XH, Zhang SY, Wu ZC, Jiang FB, Li HY . Clinical observation on the effect of Jinju Qingrun capsule on 50 cases of primary Sjogren's syndrome[J]. Zhong Yi Za Zhi, 2009,50(8):708-711
张水艳, 李瑞, 朱秀惠, 张韶英, 武占成, 蒋富斌, 李惠云 . 金菊清润胶囊治疗原发性干燥综合征50例临床观察[J]. 中医杂志, 2009,50(8):708-711
[17] Yang AQ . Clinical observation of integrated traditional Chinese and Western medicine in treating 85 cases of Sjogren's syndrome[J]. Zhongguo Yi Yao Dao Bao, 2009,6(26):77-78
doi: 10.3969/j.issn.1673-7210.2009.26.046
杨爱琴 . 中西医结合治疗干燥综合征85例临床观察[J]. 中国医药导报, 2009,6(26):77-78
doi: 10.3969/j.issn.1673-7210.2009.26.046
[18] Wang ZZ . Clinical study on patient with primary Sjogren's syndrome with traditional Chinese medicine and Western medicine[J]. Zhongguo Dang Dai Yi Yao, 2009,16(17):46-47
王章正 . 中西药合用治疗原发性干燥综合征临床研究[J]. 中国当代医药, 2009,16(17):46-47
[19] Wang WP, Shi SM . Clinical observation on effectiveness of self-made Yangyin Jianpi Huoxue decoction in combination with conventional therapy in the treatment of Sjogren's syndrome[J]. Zhonghua Zhong Yi Yao Za Zhi, 2009,24(7):902-903
王薇萍, 史生铭 . 自拟养阴健脾活血汤结合常规治疗干燥综合征临床疗效观察[J]. 中华中医药杂志, 2009,24(7):902-903
[20] Wan QB . Integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome[J]. Hubei Zhong Yi Za Zhi, 2009,31(7):26-27
万琦兵 . 中西医结合治疗干燥综合征[J]. 湖北中医杂志, 2009,31(7):26-27
[21] Su X, Zhang N . The clinical study of traditional Chinese medicine for Yangyin Huoxue Shengjin Fang in treating yin asthenia generating intrinsic heat and blood stasis due to loss of body fluid of Sjogren's syndrome[J]. Zhonghua Zhong Yi Yao Xue Kan, 2009,27(11):2264-2268
苏晓, 张娜 . 养阴活血生津法治疗干燥综合征[J]. 中华中医药学刊, 2009,27(11):2264-2268
[22] Mao LP, Han B, Yan PS, Liu AL, Shi AM . Clinical observation of integrated traditional Chinese and Western medicine in treating 50 cases of Sjogren's syndrome[J]. Zhongguo Lao Nian Xue Za Zhi, 2009,29(21):2811-2812
doi: 10.3969/j.issn.1005-9202.2009.21.054
毛兰萍, 韩冰, 闫磐石, 刘爱莲, 石爱梅 . 中西医结合治疗干燥综合征50例的临床观察[J]. 中国老年学杂志, 2009,29(21):2811-2812
doi: 10.3969/j.issn.1005-9202.2009.21.054
[23] Lu Y, Jin S . Clinical study on Shengjin granule in the treatment of primary Sjogren's syndrome with yin-deficiency and collateral stagnation syndrome[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao, 2009,25(6):421-423
陆燕, 金实 . 生津颗粒治疗原发性干燥综合征阴虚络滞证临床研究[J]. 南京中医药大学学报, 2009,25(6):421-423
[24] Lian J . Clinic research on treating primary Sjogren's syndrome with the method of Yang Yin Sheng Jin, Run Zao Tong Luo ways. Nanjing: Nanjing University of Chinese Medicine. 2009. Chinese with abstract in English.
doi: 10.7666/d.y1543734
廉杰 . 养阴生津、润燥通络法治疗原发性干燥综合征阴虚络滞证的临床研究. 南京: 南京中医药大学. 2009.
doi: 10.7666/d.y1543734
[25] Huang XJ, Tong XH, Zhang YP . Clinical research on patients of primary Sjogren's syndrome treated by traditional Chinese medicine of Yiqi Yangyin Huoxue method and anethole trithione[J]. Hang Kong Hang Tian Yi Yao, 2009,20(2):65-66
doi: 10.3969/j.issn.2095-1434.2009.02.001
黄晓娟, 佟晓辉, 张云鹏 . 益气养阴活血法中药结合环戊硫酮片治疗原发干燥综合征的临床观察[J]. 航空航天医药, 2009,20(2):65-66
doi: 10.3969/j.issn.2095-1434.2009.02.001
[26] Gao L, Ma LH, Ji XD . Clinical observation of integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome[J]. Zhongguo Zhong Yi Yao Xian Dai Yuan Cheng Jiao Yu, 2009,7(3):30
高黎, 马丽华, 季旭东 . 中西医结合治疗干燥综合征的临床观察[J]. 中国中医药现代远程教育, 2009,7(3):30
[27] Zhong QC. Clinical research on Yangyin Tongluo method in treating Sjogren's syndrome. In: Wu YL. Basic and clinical research on collateral disease theory(4)[M]. Beijing: Military Medical Science Press, 2008: 387-390
钟起诚 . 养阴通络法治疗干燥综合征的临床研究. 见: 吴以岭. 络病学基础与临床研究(4)[M]. 北京: 军事医学科学出版社, 2008: 387-390
[28] Feng FH, Zhang EZ . Total glycosides of paeony in the treatment of 42 cases of Sjogren's syndrome[J]. Zhong Yi Yan Jiu, 2008,21(12):35-37
doi: 10.3969/j.issn.1001-6910.2008.12.016
冯福海, 张二中 . 白芍总苷治疗干燥综合征42例[J]. 中医研究, 2008,21(12):35-37
doi: 10.3969/j.issn.1001-6910.2008.12.016
[29] Lü WZ, Li CX, Sun GJ, Wang YF, Liu ZH . Clinical research on Jinyuan decoction for 74 cases of primary Sjogren's syndrome[J]. Zhong Yi Za Zhi, 2008,49(1):29-31
吕文增, 李春先, 孙国剑, 王玉芳, 刘哲慧 . 津原汤治疗原发性干燥综合征74例临床观察[J]. 中医杂志, 2008,49(1):29-31
[30] Jin GL, Wang Y, Yan TT, Sun LX . Zengye Runzao decoction in the treatment of 47 cases of primary Sjogren's syndrome[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao, 2008,24(4):268-269
doi: 10.3969/j.issn.1000-5005.2008.04.018
金桂兰, 汪悦, 晏婷婷, 孙丽霞 . 增液润燥汤治疗原发性干燥综合征47例[J]. 南京中医药大学学报, 2008,24(4):268-269
doi: 10.3969/j.issn.1000-5005.2008.04.018
[31] Han SH, Jin S, Liu ZT, Wei G, Wu J, Zhu BB . Clinical study on 38 cases of primary Sjogren's syndrome patients treated with Xuanfei Bujin particles[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2008,15(12):14-16
doi: 10.3969/j.issn.1005-5304.2008.12.007
韩善夯, 金实, 刘征堂, 魏刚, 武剑, 朱蓓蓓 . 宣肺布津颗粒治疗原发性干燥综合征38例临床研究[J]. 中国中医药信息杂志, 2008,15(12):14-16
doi: 10.3969/j.issn.1005-5304.2008.12.007
[32] Chen AP . Observation on effectiveness of Yiqi Shengjin powder in the treatment of Sjogren's syndrome[J]. Shanxi Zhong Yi, 2008,24(5):13-14
doi: 10.3969/j.issn.1000-7156.2008.05.007
陈爱萍 . 益气生津散治疗干燥综合征疗效观察[J]. 山西中医, 2008,24(5):13-14
doi: 10.3969/j.issn.1000-7156.2008.05.007
[33] Wu CH, Wang HT . Clinical observation on modified Maiwei Dihuang decoction in the treatment of Sjogren's syndrome[J]. Beijing Zhong Yi, 2007,26(1):36-37
吴春华, 王和天 . 加味麦味地黄汤治疗干燥综合征的临床观察[J]. 北京中医, 2007,26(1):36-37
[34] Yan LP . Integrated traditional Chinese and Western medicine in the treatment of 30 cases of Sjogren's syndrome[J]. Changchun Zhong Yi Yao Da Xue Xue Bao, 2007,23(4):80
严立平 . 中西医结合治疗干燥综合征30例[J]. 长春中医药大学学报, 2007,23(4):80
[35] Sun GJ, Li CX, Lü WZ . Clearing and dredging therapy in the treatment of 74 cases of primary Sjogren's syndrome[J]. Shandong Zhong Yi Za Zhi, 2007,26(7):456-458
doi: 10.3969/j.issn.0257-358X.2007.07.011
孙国剑, 李春先, 吕文增 . 清利疏通法治疗原发性干燥综合征74例[J]. 山东中医杂志, 2007,26(7):456-458
doi: 10.3969/j.issn.0257-358X.2007.07.011
[36] Shen YB, Zheng CM . Clinical observation on the effectiveness of compound glycyrrhizin in the treatment of primary Sjogren's syndrome[J]. Zhongguo Chu Fang Yao, 2007,( 9):76
沈雁冰, 郑纯梅 . 复方甘草酸苷治疗原发性干燥综合征的临床效果观察[J]. 中国处方药, 2007,( 9):76
[37] Mao JC, Chen XJ, Su L, Gu JH, Chen XY . Clinical effects of Yi-Qi-Jian-Pi therapy on Sjogren's syndrome[J]. Zhongguo Lin Chuang Yao Xue Za Zhi, 2007,16(4):231-233
doi: 10.3969/j.issn.1007-4406.2007.04.011
茅建春, 陈湘君, 苏励, 顾军花, 陈晓云 . 益气健脾法治疗原发性干燥综合征的临床观察[J]. 中国临床药学杂志, 2007,16(4):231-233
doi: 10.3969/j.issn.1007-4406.2007.04.011
[38] Li F, Yao JH, Zhang FX, Sun LJ, Tao JM, Ning XR . Clinical observation on treatment of primary Sjogren's syndrome by compound glycyrrhizin injection[J]. Zhongguo Yao Fang, 2007,18(11):858-859
李芳, 姚建华, 张风肖, 孙丽君, 陶杰梅, 宁晓然 . 复方甘草酸苷注射液治疗原发性干燥综合征的临床观察[J]. 中国药房, 2007,18(11):858-859
[39] Zhou SG . Dryness-clearing, detoxifying, yin-tonifying and collateral vessel-freeing therapy in the treatment of 30 cases of Sjogren's syndrome[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2006,13(7):66-67
doi: 10.3969/j.issn.1005-5304.2006.07.037
]周时高 . 清燥解毒、养阴通络法治疗干燥综合征30例[J]. 中国中医药信息杂志, 2006,13(7):66-67
doi: 10.3969/j.issn.1005-5304.2006.07.037
[40] Zhou DH, Xu Y, Wu J, Jin Y, Zhang QD, Zhou ZQ . Clinical observation on Dandi Qiongyu granules in the treatment of primary Sjogren's syndrome[J]. Zhongguo Zhong Yi Ji Zheng, 2006,15(3):252-253
doi: 10.3969/j.issn.1004-745X.2006.03.019
周定华, 徐艳, 吴炅, 金艳, 张前德, 周正球 . 丹地琼玉颗粒治疗原发性干燥综合征临床观察[J]. 中国中医急症, 2006,15(3):252-253
doi: 10.3969/j.issn.1004-745X.2006.03.019
[41] Wu GL, Han YM, Fan YS, Yu GY . Effects of Chinese herbal medicine for Yiqi Yangyin Quyu in treating Sjogren's syndrome and on patients’ immunologic function[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2006,26(4):322-324
doi: 10.7661/CJIM.2006.4.322
吴国琳, 韩咏梅, 范永升, 余国友 . 益气养阴祛瘀中药治疗干燥综合征的临床疗效及其对免疫功能的影响[J]. 中国中西医结合杂志, 2006,26(4):322-324
doi: 10.7661/CJIM.2006.4.322
[42] Shen K, Ma HL, Guo SM, Lü LK . Clinical study of treating of primary Sjogren's syndrome by Runzao oral liquid[J]. Hebei Yi Xue, 2006,12(2):124-126
doi: 10.3969/j.issn.1006-6233.2006.02.013
申康, 马洪玲, 郭双敏, 吕兰凯 . 润燥口服液治疗原发性干燥综合征临床研究[J]. 河北医学, 2006,12(2):124-126
doi: 10.3969/j.issn.1006-6233.2006.02.013
[43] Niu YF, Liu J, Huang CB, Chen X . The clinical effect of invigorating spleen to eliminate dampness and cooling heat in treating SS[J]. Zhongguo Lin Chuang Bao Jian Za Zh, 2006,9(5):445-447
doi: 10.3969/j.issn.1672-6790.2006.05.013
牛云飞, 刘健, 黄传兵, 谌曦 . 健脾化湿清热法治疗干燥综合征疗效观察[J]. 中国临床保健杂志, 2006,9(5):445-447
doi: 10.3969/j.issn.1672-6790.2006.05.013
[44] Chen XY, Chen XJ, Gu JH . Suangan Shengjin therapy in the treatment of 40 cases of Sjogren's syndrome[J]. Shaanxi Zhong Yi, 2006,27(11):1361-1363
陈晓云, 陈湘君, 顾军花 . 酸甘生津法治疗干燥综合征40例[J]. 陕西中医, 2006,27(11):1361-1363
[45] Yang XY, Wang Y . Clinical observation on acupuncture in combination with herbal medicine in the treatment of 42 cases of Sjogren's syndrome[J]. Shandong Zhong Yi Yao Da Xue Xue Bao, 2005,29(4):292
doi: 10.3969/j.issn.1007-659X.2005.04.019
杨晓砚, 王熠 . 针药合用治疗干燥综合征42例临床观察[J]. 山东中医药大学学报, 2005,29(4):292
doi: 10.3969/j.issn.1007-659X.2005.04.019
[46] Si XW . Clinical observation on herbal medicine in combination with pressing ear in the treatment of 38 cases of Sjogren's syndrome[J]. Jiangsu Zhong Yi Yao, 2005,26(10):39-40
司晓文 . 口服中药结合耳压治疗口眼干燥综合征38例临床观察[J]. 江苏中医药, 2005,26(10):39-40
[47] Liu W, Wang H, Yang XY, Zuo F, Chen FY . Clinical observation on Qingzao formula in the treatment of Sjogren's syndrome[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005,25(1):53
doi: 10.7661/CJIM.2005.1.53
刘维, 王慧, 杨晓砚, 左芳, 陈伏宇 . 清燥方治疗干燥综合征临床观察[J]. 中国中西医结合杂志, 2005,25(1):53
doi: 10.7661/CJIM.2005.1.53
[48] Zhao ZW, Wang WR . Modified Qiju Dihuang decoction in the treatment of 30 cases of primary Sjogren's syndrome[J]. Zhongguo Zhong Yi Yao Ke Ji, 2003,10(5):314-315
赵钟文, 王文荣 . 杞菊地黄汤加减治疗原发性干燥综合征30例[J]. 中国中医药科技, 2003,10(5):314-315
[49] Qian X, Mang YZ, Zhang MJ, Ji W, Lu SJ, Lu Y . The clinical study of treatment for SS with Jinxueyuan[J]. Zhonghua Shi Yong Zhong Xi Yi Za Zhi, 2003,16(7):975-977
钱先, 马永桢, 张梅涧, 纪伟, 陆双军, 陆燕 . 津血源治疗干燥综合征的临床研究[J]. 中华实用中西医杂志, 2003,16(7):975-977
[50] Zhong QC . Observation on effectiveness of traditional Chinese medicine in the treatment of Sjogren's syndrome complicated with blood system damage[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,23(12):933-934
doi: 10.7661/CJIM.2003.12.933
钟起诚 . 中医药治疗干燥综合征合并血液系统损害的疗效观察[J]. 中国中西医结合杂志, 2003,23(12):933-934
doi: 10.7661/CJIM.2003.12.933
[51] Li CX, Yang GL, Feng YH, Shi YJ, Tan QJ . Observation on the effectiveness of Shengmai injection in the treatment of primary Sjogren's syndrome[J]. Shi Zhen Guo Yi Guo Yao, 2002,13(2):92-93
李春先, 杨桂玲, 冯玉环, 石颜军, 谭秋菊 . 生脉注射液治疗原发性干燥综合征疗效观察[J]. 时珍国医国药, 2002,13(2):92-93
[52] Wu SF . Ziyin Huoxue formula in the treatment of 30 cases of Sjogren's syndrome[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2002,9(8):51-52
武士芬 . 滋阴活血方治疗干燥综合征30例[J]. 中国中医药信息杂志, 2002,9(8):51-52
[53] Cui XG, Zhang FC . Runfei Huatan Tongluo therapy in the treatment of 25 cases of Sjogren's syndrome[J]. Zhongguo Min Jian Liao Fa, 2002,10(8):47-48
doi: 10.3969/j.issn.1007-5798.2002.08.075
崔晓光, 张丰川 . 润肺化痰通络法治疗干燥综合征25例[J]. 中国民间疗法, 2002,10(8):47-48
doi: 10.3969/j.issn.1007-5798.2002.08.075
[54] Shen K . Liuwei Dihuang decoction in combination with Zengye decoction in the treatment of 30 cases of primary Sjogren's syndrome[J]. Shandong Zhong Yi Za Zhi, 2002,21(8):467-469
doi: 10.3969/j.issn.0257-358X.2002.08.007
申康 . 六味地黄汤合增液汤治疗原发性干燥综合征30例[J]. 山东中医杂志, 2002,21(8):467-469
doi: 10.3969/j.issn.0257-358X.2002.08.007
[55] Hu CM . Analysis of the therapeutic effect of Zengye mixture on 100 cases of Sjogren's syndrome[J]. Zhongguo Re Dai Yi Xue, 2001,1(4):336-337
doi: 10.3969/j.issn.1009-9727.2001.04.020
胡传美 . 增液合剂治疗干燥综合征100例疗效分析[J]. 中国热带医学, 2001,1(4):336-337
doi: 10.3969/j.issn.1009-9727.2001.04.020
[56] Wang H, Liu W, Zuo F . Observation on the effectiveness of Runzao mixture in the treatment of 40 cases of Sjogren's syndrome[J]. Tianjin Zhong Yi Xue Yuan Xue Bao, 2000,19(2):29
doi: 10.3969/j.issn.1673-9043.2000.02.018
王慧, 刘维, 左芳 . 润燥合剂治疗干燥综合征40例疗效观察[J]. 天津中医学院学报, 2000,19(2):29
doi: 10.3969/j.issn.1673-9043.2000.02.018
[57] Feng YH, Tian ZQ, Song DB, Zhou YF, Zhang J . Observation on the effectiveness of Shengjin Runzao granules in the treatment of primary Sjogren's syndrome[J]. Shi Zhen Guo Yi Guo Yao, 2000,11(4):327
doi: 10.3969/j.issn.1008-0805.2000.04.038
冯玉环, 田在泉, 宋代波, 周玉芳, 张谨 . 生津润燥冲剂治疗原发性干燥综合征疗效观察[J]. 时珍国医国药, 2000,11(4):327
doi: 10.3969/j.issn.1008-0805.2000.04.038
[58] Chen YF, Ren JS, Han CJ . Qingzao Jiufei decoction with Dahuang Zhechong pill in the treatment of 26 cases of Sjogren's syndrome: 12 cases treated with Western medicine[J]. Zhejiang Zhong Yi Za Zhi, 2000,35(2):57
doi: 10.3969/j.issn.0411-8421.2000.02.014
陈一峰, 任军生, 韩朝军 . 清燥救肺汤合大黄虫丸治疗干燥综合征26例: 附西药治疗12例对照观察[J]. 浙江中医杂志, 2000,35(2):57
doi: 10.3969/j.issn.0411-8421.2000.02.014
[59] Liao CJ . Modified Mendong Qingfei drink in the treatment of 32 cases of Sjogren's syndrome[J]. Xin Zhong Yi, 1999,31(4):44
doi: 10.3969/j.issn.0256-7415.1999.04.027
廖承建 . 门冬清肺饮加减治疗干燥综合征32例[J]. 新中医, 1999,31(4):44
doi: 10.3969/j.issn.0256-7415.1999.04.027
[60] Yang ZH, Liu SL . Observation on the effectiveness of large dosage of Qingkailing injection in the treatment of 12 cases of Sjogren's syndrome[J]. Shandong Yi Yao, 1998,38(9):54
杨宗华, 刘双兰 . 大剂量清开灵治疗干燥综合征12例疗效观察[J]. 山东医药, 1998,38(9):54
[61] Zhou Q, Zhu HQ . Integrated traditional Chinese and Western medicine in the treatment of 34 cases of Sjogren's syndrome[J]. Xin Zhong Yi, 1997,29(8):29-30
周勤, 朱华群 . 中西医结合治疗干燥综合征34例[J]. 新中医, 1997,29(8):29-30
[62] Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH ; European Study Group on Classification Criteria for Sjögren’s Syndrome.Integrated traditional Chinese and Western medicine in the treatment of 34 cases of Sjögren's syndrome[J]. Ann Rheum Dis, 2002,61(6):554-558
doi: 10.1136/ard.61.6.554
[63] Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, Braga S, Coll J, de Vita S, Drosos AA, Ehrenfeld M, Hatron PY, Hay EM, Isenberg DA, Janin A, Kalden JR, Kater L, Konttinen YT, Maddison PJ, Maini RN, Manthorpe R, Meyer O, Ostuni P, Pennec Y, Prause JU, Richards A, Sauvezie B, Schi ødt M, Sciuto M, Scully C, Shoenfeld Y, Skopouli FN, Smolen JS, Snaith ML, Tishler M, Todesco S, Valesini G, Venables PJW, Wattiaux MJ, Youinou P. Preliminary criteria for the classification of Sjogren's syndrome. Results of a prospective concerted action supported by the European Community[J]. Arthritis Rheum, 1993,36(3):340-347
doi: 10.1002/(ISSN)1529-0131
[64] Dong Y, Zhao Y, Guo XP, Li XC, Tang FL, Gao Y, Zhao JL . Preliminary diagnostic criteria for primary Sjogren's syndrome in China[J]. Zhonghua Nei Ke Za Zhi, 1996,35(2):114-117
doi: 10.1007/BF02951625
董怡, 赵岩, 郭晓萍, 李小春, 唐福林, 高岩, 赵家良 . 原发性干燥综合征诊断标准的初步研究[J]. 中华内科杂志, 1996,35(2):114-117
doi: 10.1007/BF02951625
[65] Zhang NZ. Clinical rheumatology[M]. Shanghai: Shanghai Scientific and Technical Publishers, 1999: 288
张乃峥 . 临床风湿病学[M]. 上海: 上海科学技术出版社, 1999: 288
[66] State administration of traditional Chinese medicine of the People’s Republic of China. Criteria of diagnosis and therapeutic effect evaluation of diseases and syndromes in traditional Chinese medicine[M]. Nanjing: Nanjing University Press, 1994
中华人民共和国国家中医药管理局. 中医病症诊断疗效标准[M]. 南京: 南京大学出版社, 1994
[67] Lu JJ. Practical study of connective tissue[M]. Beijing: People’s Medical Publishing House, 1987: 651-665
卢君健 . 实用结缔组织学[M]. 北京: 人民卫生出版社, 1987: 651-665
[68] Manthorpe R, Frost-Larsen K, Isager H, Prause JU . Sjogren's syndrome. A review with emphasis on immunological features[J]. Allergy, 1981,36(3):139-153
doi: 10.1111/all.1981.36.issue-3
[69] Zheng XY. Guidelines for clinical research on Chinese new herbal medicines(trial implementation)[M]. Beijing: China Medical Science Press, 2002
郑筱萸 . 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002
[70] Sun CX. Diagnosis and standard of cure or improvement of clinical diseases(2nd ed)[M]. Beijing: People’s Military Medical Press, 1998
孙传兴 . 临床疾病诊断依据治愈好转标准(第2版)[M]. 北京: 人民军医出版社, 1998
[71] Fox RI . Sjogren's syndrome[J]. Lancet, 2005,366(9482):321-331
doi: 10.1016/S0140-6736(05)66990-5
[72] Schulz KF, Altman DG, Moher D ;CONSORT Group . CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials[J]. BMJ, 2010,340:c332
doi: 10.1136/bmj.c332
[1] Jia Xu, Fu-qing Zhang, Jian Pei, Jun Ji . Acupuncture for migraine without aura: A systematic review and meta-analysis. Journal of Integrative Medicine, 2018, 16(5): 312-321.
[2] Qian-wen Ma, Yong Tan. Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome: A meta-analysis. Journal of Integrative Medicine, 2017, 15(2): 95-101.
[3] Maria T.Chao, AlexandraChang, SanjayReddy, James D.Harrison, JosephAcquah, MiriaToveg, TrilceSantana, Frederick M.Hecht. Adjunctive acupuncture for pain and symptom management in the inpatient setting: Protocol for a pilot hybrid effectiveness-implementation study. Journal of Integrative Medicine, 2016, 14(3): 228-238.
[4] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[5] Sung Min Lim, Sook-Hyun Lee. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: A systematic review and meta-analysis. Journal of Integrative Medicine, 2015, 13(4): 241-247.
[6] Zhong-liang Liu, Wei-rong Zhu, Wen-chao Zhou, Hai-feng Ying, Lan Zheng, Yuan-biao Guo, Jing-xian Chen, Xiao-heng Shen. Traditional Chinese medicinal herbs combined with epidermal growth factor receptor tyrosine kinase inhibitor for advanced non-small cell lung cancer: A systematic review and meta-analysis. Journal of Integrative Medicine, 2014, 12(4): 346-358.
[7] Zhi-yi Zhou, Ling Xu, He-gen Li, Jian-hui Tian, Li-jing Jiao, Sheng-fu You, Zhi-fen Han, Yi Jiang, Hui-ru Guo​, Hui Liu​. Chemotherapy in conjunction with traditional Chinese medicine for survival of elderly patients with advanced non-small-cell lung cancer: Protocol for a randomized double-blind controlled trial. Journal of Integrative Medicine, 2014, 12(3): 175-181.
[8] Heather Ann Hausenblas, Debbie Saha, Pamela Jean Dubyak, Stephen Douglas Anton. Saffron (Crocus sativus L.) and major depressive disorder: A meta-analysis of randomized clinical trials. Journal of Chinese Integrative Medicine, 2013, 11(6): 377-383.
[9] Jian Liu, Chuan-bing Huang, Yuan Wang, Gui-qin Xu, Yuan-yuan Cheng, Yun-xia Feng, Lei Liu, Ya-jun Qi. Chinese herbal medicine Xinfeng Capsule in treatment of rheumatoid arthritis: Study protocol of a multicenter randomized controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(6): 428-434.
[10] Tian-zhan Wang, Yu Chen, Yan-ming He, Xiao-dong Fu, Wang Yi, Yan-qiu Xu, Hong-jie Yang, Hong-li Xue, Yi Liu, Xiao-tao Feng, Teng Zhang, Wen-jian Wang. Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(3): 175-183.
[11] Chung-wah Cheng, Shu-fei Fu, Qing-hui Zhou, Tai-xiang Wu, Hong-cai Shang, Xu-dong Tang, Zhi-shun Liu, Jia Liu, Zhi-xiu Lin, Lixing Lao, Ai-ping Lü, Bo-li Zhang, Bao-yan Liu, Zhao-xiang Bian. Extending the CONSORT Statement to moxibustion. Journal of Chinese Integrative Medicine, 2013, 11(1): 54-63.
[12] Hui Luo, Jian-ping Liu, Qing Li. Methodological issues and suggestions for improvement in randomized controlled trials of Chinese herbal medicine for recurrent miscarriage. Journal of Chinese Integrative Medicine, 2012, 10(6): 604-614.
[13] Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao, Ya-ming Li . Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 628-634.
[14] Li-xin Ma, Yu-yi Wang, Xin-xue Li, Jian-ping Liu . Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(3): 279-292.
[15] Paula de Sousa Fragoso Ana, de Sá Ferreira Arthur. Evaluation of the immediate effects of manual acupuncture on brachial bicep muscle function in healthy individuals and poststroke patients: a study protocol of a parallel-group randomized clinical trial. Journal of Chinese Integrative Medicine, 2012, 10(3): 303-309.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[4] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[5] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[6] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[7] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[8] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[9] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[10] Nian-hong Wang , Jun-tao Yan , Wu-quan Sun , Yong-shan Hu , Jun Xia , Li-cheng Wei , Jie Jia , Gui-lin Ouyang , Yong He , Yan-ming Guo , Jie Xu . Effects of early application of Tuina treatment on quadriceps surface myoelectricity in patients after total knee arthroplasty: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1247-1253