Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (4): 315-324.doi: 10.3736/jcim20090404

• Systematic Review • Previous Articles     Next Articles

Aidi Injection as an adjunct therapy for non-small cell lung cancer: A systematic review

Wen-hua Ma , Kai-nan Duan, Min Feng, Bin She, Yan Chen, Rui-ming Zhang   

  1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2008-10-20 Accepted:2009-01-08 Online:2009-04-20 Published:2009-04-15

Objective

To assess methodological quality of clinical studies using Aidi Injection as an adjunct therapy for non-small cell lung cancer (NSCLC) and to evaluate the effects of Aidi Injection.
Methods

PubMed (1980-2008), Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 3, 2008), EMBASE (1984-2008), CancerLit (1996-2003), CBMdisc (1980-2008), CNKI database (1980- 2008), Wanfang database (1980-2008), and Chongqing VIP database (1980-2008) were searched. The authors also hand-searched Chinese periodicals potentially related to the question. All randomized controlled trials comparing Aidi Injection with other treatment methods of NSCLC were included. Two reviewers selected studies, assessed the quality of studies, and extracted the data independently. The included studies were appraised and analyzed by Cochrane Collaboration Review Manager 5.0.
Results

Fourteen randomized controlled trials were included in the meta-analysis, but the quality of reports of the 14 included studies was poor. Aidi Injection combined with cobalt-60 or navelbine and platinol (NP) showed statistically significant differences in improving the response rate as compared with single use of cobalt-60 (P = 0.000 2) or NP (P = 0.04), and the relative risk (RR) and 95% confidence interval (Cl) were 1.93[1.36, 2.72] and 1.18[1.00, 1. 38], respectively. However, Aidi Injection combined with etoposide and platinol (EP), taxinol and platinol (TP) or gamma knife showed no significant differences as compared with single use of EP (P = 0.60),TP (P = 0.16) or gamma knife (P = 0.34),respectively. The RR and 95% Cl of EP, TP and gamma knife were 1. 17[〇. 65, 2. 09], 1. 27[〇. 91, 1. 78] and 1. 08 [0.92, 1. 26] respectively. Six studies indicated that Aidi Injection combined with NP or gamma knife could improve the quality of life. Six studies showed that Aidi Injection combined with NP or TP could improve the bone marrow hematopoietic function. Three studies indicated that Aidi Injection combined with NP could improve the immune function. Three studies showed that the combined therapy could not improve 1-, 2-,and 3-year survival rates.
Conclusion

The results of meta-analysis indicate that treatment of NSCLC patients, but the sample size is publication bias is found. The effects of Aidi Injection controlled trials.

Key words: Aidi Injection, Non-small cell lung cancer, Stematic review, Randomized controlled trials

Figure 1

Risk of bias from the included trials"

Figure 2

Summary of the risk of bias from the included trials"

Figure 3

Meta-analysis of the included trials on effective rate"

Figure 4

Meta-analysis of the included trials on quality of life"

Figure 5

Meta-analysis of the included trials on myelosuppression"

Figure 6

Meta-analysis of the included trials on immune function"

Figure 7

Meta-analysis of the included trials on survival rate"

Figure 8

Funnel plot"

[1] Parkin M, Bray F, Ferlay J, Pisani P . Global cancer statistics, 2002[J]. CA Cancer J Clin, 2002,55(2):74-108
[2] Sun Y, Lin HS, Zhu YZ, Feng JF, Chen ZT, Li GS, Zhang XR, Zhang ZQ, Tang JF, Shi MQ, Hao XZ, Han H . A randomized, prospective, multi-centre clinical trial of NP regimen(vinorelbine+cisplatin) plus Gensing Rg3 in the treatment of advanced non-small cell lung cancer patients[J]. Zhongguo Fei Ai Za Zhi, 2006,9(3):254-258
孙燕, 林洪生, 朱允中, 冯继锋, 陈正堂, 李攻戍, 张湘茹, 张宗岐, 唐俊舫, 史美祺, 郝学志, 韩慧 . 长春瑞滨合并顺铂(NP)加参一胶囊或安慰剂治疗晚期非小细胞肺癌的多中心双盲随机临床研究报告[J]. 中国肺癌杂志, 2006,9(3):254-258
[3] Yu SZ, Yang GH, Feng JM . Clinical study on treatment of malignant neoplasms with Shenqi Fuzheng Injection and chemotherapy[J]. J Chin Integr Med, 2006,4(1):84-86
余胜珠, 杨光华, 冯金梅 . 参芪扶正注射液联合化疗治疗恶性肿瘤86例临床观察[J]. 中西医结合学报, 2006,4(1):84-86
[4] Tian HQ, Liang GW, Huang XQ, Huang ZQ, Lang JM, Zhang YP, Chen XZ, Chen YS . Prospective randomized controlled study on complex treatment of traditional Chinese medicine to advanced primary hepatocarcinoma[J]. Zhongguo Yi Yao Dao Bao, 2008,5(31):17-21
田华琴, 梁贵文, 黄小青, 黄志庆, 郎江明, 张玉萍, 陈学彰, 陈银崧 . 中医综合治疗方案治疗原发性中晚期肝癌的前瞻、随机、对照研究[J]. 中国医药导报, 2008,5(31):17-21
[5] Tatsuka M, Maeda M, Ota T . Anticarcinogenic effect and enhancement of metastatic potential of BALB/c 3T3 cells by ginsenoside Rh2[J]. Jpn J CancerRes, 2001,92(11):1184-1189
doi: 10.1111/cas.2001.92.issue-11
[6] Liu DY, Li FJ, Wang CY, Huang L, Li F, Zhang P, Lu YP, Ma D . Effect of Aidi injection on the proliferation of ovarian carcinoma cell line A2780 and its synergetic effect with chemotherapy drugs[J]. Xian Dai Fu Chan Ke Jin Zhan, 2005,14(4):47-49
刘德艳, 李辅军, 王常玉, 黄磊, 李芳, 张萍, 卢运萍, 马丁 . 艾迪注射液及联合应用化疗药物抑制人卵巢癌细胞株A2780增殖的研究[J]. 现代妇产科进展, 2005,14(4):47-49
[7] Cheng XJ, Li PZ, Shang XH, Li BJ, Zhu CL . Effects of Acanthopanacis Senticosi polysaccharides in enhancing immune function and antitumour[J]. Ai Zheng, 1984,3(3):191-193
程秀娟, 李佩珍, 商晓华, 李伯军, 朱春来 . 刺五加多糖的抗肿瘤作用及免疫作用[J]. 癌症, 1984,3(3):191-193
[8] Lian ML, Wang YY, Yan MS, Li YY . Effect of norcantharidin on the immune system of mice[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,6(23):153-156
连慕兰, 汪妍瑜, 严明山, 李妍妍 . 去甲斑鳌素对小鼠免疫系统的影响[J]. 中国中西医结合杂志, 2003,6(23):153-156
[9] Chen MW, Ma AQ, Ni L, Huang C, Zhang DZ, Niu XY . Effect of ginsenoside on the cellular proliferation, apoptosis and cell cycles in LC A549 and HUVEC304 cell lines[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2005,30(2):149-152
陈明伟, 马爱群, 倪磊, 黄晨, 张殿增, 牛小英 . 人参皂甙对肺癌细胞和血管内皮细胞增生、凋亡及其周期的影响[J]. 中南大学学报 (医学版), 2005,30(2):149-152
[10] Huang CJ, Liu JB, Huang N . Aidi Injection plus chemotherapy in treatment of 30 elderly cases of non-small cell lung cancer[J]. Zhonghua Shi Yong Zhong Xi Yi Za Zhi, 2006,19(1):63-64
黄常江, 刘俊波, 黄能 . 艾迪注射液联合化疗治疗老年非小细胞肺癌30例[J]. 中华实用中西医杂志, 2006,19(1):63-64
[11] Wang DJ, Chen YL, Ren J, Cai Y, Liu MZ, Zhan QY . A randomized clinical study on efficacy of Aidi injection combined with chemotherapy in the treatment of advanced non-small cell lung cancer[J]. Zhongguo Fei Ai Za Zhi, 2004,7(3):247-249
王迪进, 陈颖兰, 任剑, 蔡云, 刘敏知, 詹勤元 . 艾迪注射液配合化疗治疗晚期非小细胞肺癌的随机临床研究[J]. 中国肺癌杂志, 2004,7(3):247-249
[12] Zhou H, Wang AL, Yi Q, Zhou WW . A clinical study on paclitaxel and cisplation chemotherapy combined with Aidi injection in treatment of advanced non-small cell lung cancer[J]. Shi Jie Zhong Liu Za Zhi, 2006,5(4):269-271
周辉, 汪安兰, 易青, 周文伟 . 艾迪注射液配合TP方案治疗晚期非小细胞肺癌的临床研究[J]. 世界肿瘤杂志, 2006,5(4):269-271
[13] Zhu QS, Chen YM . Clinical observation of taxotere plus cisplatin chemotherapy in combination with Aidi Injection in the treatment of non-small cell advanced lung cancer[J]. Yao Wu Liu Xing Bing Xue Za Zhi, 2006,15(3):132-139
朱青山, 陈雅敏 . 艾迪注射液联合TP方案治疗晚期非小细胞肺癌[J]. 药物流行病学杂志, 2006,15(3):132-139
[14] Zhu QS, Chen YM . Clinical observation of taxotere plus cisplatin chemotherapy in combination with Aidi Injection in the treatment of non-small cell advanced lung cancer[J]. Yao Wu Liu Xing Bing Xue Za Zhi, 2006,15(3):132-139
陈贡斌 . 艾迪注射液联合全身化疗治疗晚期非小细胞肺癌疗效观察[J]. 中国医药, 2007,2(6):333-334
[15] Wang HZ, Wang CH, Wang RX . Clinical observation on treatment of advanced non-small cell lung cancer with combination of chemotherapy and Aidi injection[J]. Zhongguo Lin Chuang Zhong Liu Yu Kang Fu, 2004,11(4):358-360
王怀璋, 王程虎, 王瑞香 . 化疗联合艾迪注射液治疗晚期非小细胞肺癌疗效观察[J]. 中国临床肿瘤与康复, 2004,11(4):358-360
[16] Cui YG, Wang WB . Clinical observation of Aidi-injection combining vinorelbine and cisplation in the treatment of advanced non-small cell lung cancer[J]. Zhong Liu Fang Zhi Za Zhi, 2005,12(6):456-458
崔言刚, 王潍博 . 艾迪注射液联合NP方案治疗晚期非小细胞肺癌临床观察[J]. 肿瘤防治杂志, 2005,12(6):456-458
[17] Hu ZX, Sun SM . Clinical observation of AiDi pro injection plus NP regimen combination in the treatment of advanced non-small-cell lung cancer[J]. Zhongguo Lin Chuang Yi Xue, 2005,12(3):530-532
胡志雄, 孙书明 . 艾迪注射液联合NP方案治疗晚期非小细胞肺癌临床观察[J]. 中国临床医学, 2005,12(3):530-532
[18] Luo XJ, Yin QY, Ma T . Observation on efficacy of navelbine and cisplation chemotherapy combined with Aidi injection in treatment of advanced non-small cell lung cancer[J]. Zhong Liu Fang Zhi Za Zhi, 2005,12(7):543-544
罗湘江, 尹青云, 马涛 . NP方案加艾迪注射液治疗非小细胞肺癌临床观察[J]. 肿瘤防治杂志, 2005,12(7):543-544
[19] Sun LH, Ji SY, Li FQ, Lu DY . Clinical study of Aidi Injection combined with NP regimen in the treatment of non-small cell lung cancer[J]. Shi Yong Zhong Liu Za Zhi, 2005,20(4):349-350
孙立红, 季淑玉, 李凤芹, 鲁德玗 . 艾迪注射液加NP方案治疗中晚期非小细胞肺癌临床疗效观察[J]. 实用肿瘤杂志, 2005,20(4):349-350
[20] Lin QJ, Zhang M, Sun Y, Xian T . Treatment of 40 cases of late non-small cell lung cancer with Aidi Injection combined with chemotherapies[J]. Beijing Zhong Yi Yao Da Xue Xue Bao Zhong Yi Lin Chuang Ban, 2007,14(2):18-20
林秋菊, 张敏, 孙英, 贤涛 . 艾迪注射液联合化疗治疗晚期非小细胞肺癌40例临床观察[J]. 北京中医药大学学报 (中医临床版), 2007,14(2):18-20
[21] Tian YP, Wang QC . Effect analysis of Aidi Injection combined with radiotherapy in treatment of elderly patients with advanced non-small cell lung cancer[J]. Zhong Yao Yao Li Yu Lin Chuang, 2007,23(4):57-58
田艳萍, 王旗春 . 艾迪联合放疗治疗老年晚期非小细胞肺癌的疗效分析[J]. 中药药理与临床, 2007,23(4):57-58
[22] Wu J . Observation of effects of Aidi Injection in the radiotherapy of non-small cell lung cancer[J]. Zhong Liu Fang Zhi Za Zhi, 2003,10(4):403-404
吴剑 . 艾迪注射液加放疗治疗非小细胞肺癌的疗效观察[J]. 肿瘤防治杂志, 2003,10(4):403-404
[23] Qian YH, Sun XD, Zhao Q . Clinical efficacy of Ai-Di with body-gamma knife in treating non-small cell lung cancer[J]. Yan Bei Shi Fan Xue Yuan Xue Bao, 2005,12(7):73-75
钱永红, 孙小东, 赵琦 . 艾迪加体部伽玛刀治疗非小细胞肺癌疗效观察[J]. 雁北师范学院学报, 2005,12(7):73-75
[24] Sun Y. Medical oncology[M]. Beijing: People’s Medical Publishing House,2001: 994-995
孙燕 . 内科肿瘤学[M]. 北京: 人民卫生出版社,2001: 994-995
[25] Hua BJ . Roles and trends of traditional Chinese medicine in treatment of malignant tumors[J]. Ai Zheng Jing Zhan, 2003,1(1):20-23
花宝金 . 中医药在恶性肿瘤综合治疗中的作用及发展趋势[J]. 癌症进展, 2003,1(1):20-23
[26] Wang JN, Ouyang XN . Status quo and prospect of traditional Chinese medicine in treating tumors[J]. Zongguo Yi Yao Dao Bao, 2008,5(3):74-76
王记南, 欧阳学农 . 中医药治疗肿瘤的现状与展望[J]. 中国医药导报, 2008,5(3):74-76
[27] Wei HF, Zheng PY, Ji G . General methods for clinical effect assessment of traditional Chinese medicine[J]. J Chin Integr Med, 2005,3(3):184-190
魏华凤, 郑培永, 季光 . 中医临床疗效评价的思路与方法[J]. 中西医结合学报, 2005,3(3):184-190
[28] Shang HC, Zhang JH, Dai GH, Cao HB, Ren M, Xiang YZ, Wang Y, Zhang BL, Li YP . Administration and quality control of large scale clinical trials of traditional Chinese medicine[J]. J Chin Integr Med, 2007,5(1):1-4
商洪才, 张俊华, 戴国华, 曹红波, 任明, 项耀祖, 汪洋, 张伯礼, 李幼平 . 中药大规模临床试验及其管理与质量控制[J]. 中西医结合学报, 2007,5(1):1-4
[1] Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[2] Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[3] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[4] Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[5] Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[6] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[7] Liang Dai, Ka Kei Chan, Jian-chun Mao, Yu Tian, Jun-hua Gu, Jun Zhou, Linda L.D. Zhong. Modified Zhibai Dihuang pill, a traditional Chinese medicine formula, on steroid withdrawal in systemic lupus erythematosus: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(6): 478-491.
[8] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[9] Xian-jun Xiao, Lei-xiao Zhang, Yun-zhou Shi, Jun-peng Yao, Wei Cao, Ying Liu, Zi-hao Zou, Si-yuan Zhou, Ming-ling Chen, Chun-xiao Li, Qian-hua Zheng, Ying Li. Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 303-312.
[10] Dong-dong Yu, Liang-zhen You, Wan-qiu Huang, Hui Cao, Fan-jing Wang, Xiu-qin Tang, Zhao-hui Fang, Guo-ming Shen, Yu-xiang Guan. Effects of traditional Chinese exercises on blood glucose and hemoglobin A1c levels in patients with prediabetes: A systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(4): 292-302.
[11] Jia Xu, Fu-qing Zhang, Jian Pei, Jun Ji . Acupuncture for migraine without aura: A systematic review and meta-analysis. Journal of Integrative Medicine, 2018, 16(5): 312-321.
[12] Maria T.Chao, AlexandraChang, SanjayReddy, James D.Harrison, JosephAcquah, MiriaToveg, TrilceSantana, Frederick M.Hecht. Adjunctive acupuncture for pain and symptom management in the inpatient setting: Protocol for a pilot hybrid effectiveness-implementation study. Journal of Integrative Medicine, 2016, 14(3): 228-238.
[13] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[14] Sung Min Lim, Sook-Hyun Lee. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: A systematic review and meta-analysis. Journal of Integrative Medicine, 2015, 13(4): 241-247.
[15] Heather Ann Hausenblas, Kacey Heekin, Heather Lee Mutchie, Stephen Antonb. A systematic review of randomized controlled trials examining the effectiveness of saffron (Crocus sativus L.) on psychological and behavioral outcomes. Journal of Integrative Medicine, 2015, 13(4): 231-240.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239