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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (7): 607-610.doi: 10.3736/jcim20090702

• Original Clinical Research • Previous Articles     Next Articles

Considerations about treatment programs of elderly patients with hypertension

Hao Li, Long-tao Liu   

  1. Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
  • Received:2009-01-09 Accepted:2009-04-14 Online:2009-07-20 Published:2009-07-15
  • Contact: Long-tao Liu

Hypertension in elderly patients is a common and frequent disease which could cause stroke, heart failure and renal dysfunction. The pathogenesis of hypertension in the elderly is different from that in the young and middle-aged people, and its clinical characteristics including frequent isolated systolic hypertension, variable blood pressure, high pulse pressure, multiple complications, serious target organ damage, and so on. High prevalence, disability and mortality rates and low awareness, treatment and control rates are prominent phenomena in the elderly patients with hypertension, bring many difficulties for clinical treatment. Presently, drug therapies for elderly patients mainly include Western medicine (WM), traditional Chinese medicine (TCM), and integrated traditional Chinese and Western medicine. WM therapy has superiority in lowering blood pressure intensively with clear mechanism, but has more adverse reactions. The effects of TCM therapy are multilinked, and TCM is good at reducing side effects and improving symptoms, but TCM preparation falls behind and its hypotensive effects are weak and slow. Furthermore, more multicenter, randomized, controlled and double-blinded clinical trials with large sample are needed to identify the effects of TCM therapy. Based on combination of TCM syndrome differentiation and WM disease differentiation, treatment programs of integrated traditional Chinese and Western medicine would take advantages of both TCM and WM treatment modalities, and are worthy of being studied in the future.

Key words: Hypertension, Elderly, Integrated traditional Chinese and Western medicine, Treatment protocols

[1] Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program(SHEP). SHEP Cooperative Research Group[J]. JAMA, 1991,265(24):3255-3264
doi: 10.1001/jama.1991.03460240051027
[2] Wang W, Zhao D . Epidemiology of elderly patients with hypertension in China[J]. Zhonghua Lao Nian Yi Xue Za Zhi, 2005,24(4):246-247
王薇, 赵冬 . 中国老年人高血压的流行病学[J]. 中华老年医学杂志, 2005,24(4):246-247
[3] Chobanian AV . Clinical practice. Isolated systolic hypertension in the elderly[J]. N Engl J Med, 2007,357(8):789-796
doi: 10.1056/NEJMcp071137
[4] Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ ; National Heart,Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee.Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report[J]. JAMA, 2003,289(19):2560-2572
doi: 10.1001/jama.289.19.2560
[5] Ma WJ, Liu GZ . Characteristics of target organ damage in elderly patients with hypertension[J]. Zhonghua Lao Nian Yi Xue Za Zhi, 2005,24(4):255
马文君, 刘国仗 . 老年人高血压靶器官损害特点[J]. 中华老年医学杂志, 2005,24(4):255
[6] Ministry of Health of the People's Republic of China. Guidelines for clinical research on Chinese new herbal medicines[M]. Beijing: Medical Science and Technology Publishing House of China, 1993
中华人民共和国卫生部. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 1993
[7] Li H, Liu Y, Yu ZX, Liu JG, Liu L . Effects of Jiangya Capsule combined with nimodipine on depressurization and quality of life in elderly patients with isolated systolic hypertension[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2008,15(9):8-10
doi: 10.3969/j.issn.1005-5304.2008.09.004
李浩, 刘宇, 于振宣, 刘剑刚, 刘丽 . 降压胶囊联合尼莫地平治疗老年单纯收缩期高血压疗效及对其生活质量的影响[J]. 中国中医药信息杂志, 2008,15(9):8-10
doi: 10.3969/j.issn.1005-5304.2008.09.004
[8] Li H, Guo MD, Liu JG . The effect of Jiangya capsule combined with nimodipine on ET, CGRP and AngⅡ of spontaneous hypertensive rats[J]. Zhongguo Lao Nian Xue Za Zhi, 2007,11(27):2178-2180
李浩, 郭明冬, 刘剑刚 . 降压胶囊联合尼莫地平对自发性高血压大鼠ET、CGRP及AngⅡ水平的影响[J]. 中国老年学杂志, 2007,11(27):2178-2180
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