Search JIM Advanced Search

Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (1): 13-20.doi: 10.1016/j.joim.2019.11.003

• Review • Previous Articles     Next Articles

Mechanisms of action of Sri Lankan herbal medicines used in the treatment of diabetes: A review

Dona Nirmani Ann Wijewickrama Samarakoona, Deepthi Inoka Uluwadugeb, Malith Aravinda Siriwardheneb   

  1. a Department of Biomedical Science, Faculty of Health Sciences, Koswatta, Battaramulla 10120, Sri Lanka
    b Department of Allied Health Sciences, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Soratha Mawatha, Nugegoda 10250, Sri Lanka 
  • Received:2018-11-13 Accepted:2019-05-17 Online:2020-01-15 Published:2019-11-19

Natural plant-based remedies for diabetes mellitus have been proven to be safe and effective alternatives to Western medications, and details about more than 400 plants are available in the literature. Sri Lanka is a tropical country which is blessed with many natural plant products that can be utilized for the treatment of diabetes. But the knowledge of these plant-derived remedies, especially their doses, mechanism of action and toxicity has not been extensively researched. Therefore, this review focuses on documenting the plant-based remedies that the Sri Lankan Aurvedic physicians use and the extent of research that has been carried out on each of these plant-based remedies.

Key words: Antidiabetic, Diabetes mellitus, Antioxidant, Mechanism, Natural plants, Review 

[1] Talat Albukhari, Bassem Refaat, El-Sayed Bakr, Sameh Baz, Bodour Rajab, Hossam Gadalla, Mohamed El-Boshy. Salvadora persica extract attenuates cyclophosphamide-induced hepatorenal damage by modulating oxidative stress, inflammation and apoptosis in rats. Journal of Integrative Medicine, 2022, 20(4): 348-354.
[2] Bin Zhao, Yong Chen, Shi-min Liao, Jian-ying Zheng, Shi-hua Yan, Dong-shu Zhang. Successfully treated recalcitrant atopic eczema with acupoint autohemotherapy: A case report and hypothesized mechanism of the therapy. Journal of Integrative Medicine, 2022, 20(2): 182-186.
[3] Miriam Bazzicalupo, Laura Cornara, Bruno Burlando, Alberta Cascini, Marcella Denaro, Antonella Smeriglio, Domenico Trombetta. Carpobrotus edulis (L.) N.E.Br. extract as a skin preserving agent: from traditional medicine to scientific validation. Journal of Integrative Medicine, 2021, 19(6): 526-536.
[4] Sutticha Ruangchuay, Qiang-qiang Wang, Liang-yi Wang, Jing Lin, Yong-chao Wang, Guo-huan Zhong, Katesarin Maneenoon, Ze-bo Huang, Sasitorn Chusri. Antioxidant and antiaging effect of traditional Thai rejuvenation medicines in Caenorhabditis elegans . Journal of Integrative Medicine, 2021, 19(4): 362-373.
[5] Jie-yu Zuo, Chulhun Park, Michael Doschak, Raimar Löbenberg. Are the release characteristics of Erzhi pills in line with traditional Chinese medicine theory? A quantitative study. Journal of Integrative Medicine, 2021, 19(1): 50-55.
[6] Olarewaju M. Oluba, Oghenerobor B. Akpor, Feyikemi D. Adebiyi, Sunday J. Josiah, Olayinka O. Alabi, Ayoola O. Shoyombo, Augustine O. Olusola. Effects of co-administration of Ganoderma terpenoid extract with chloroquine on inflammatory markers and antioxidant status in Plasmodium berghei-infected mice. Journal of Integrative Medicine, 2020, 18(6): 522-529.
[7] Mu-yan Kong, Le-yan Li, Yan-mei Lou, Hong-yu Chi, Jin-jun Wu. Chinese herbal medicines for prevention and treatment of colorectal cancer: from molecular mechanisms to potential clinical applications. Journal of Integrative Medicine, 2020, 18(5): 369-384.
[8] Varuni Colamba Pathiranage, Ira Thabrew, Sameera R. Samarakoon, Kamani H. Tennekoon, Umapriyatharshini Rajagopalan, Meran K. Ediriweera. Evaluation of anticancer effects of a pharmaceutically viable extract of a traditional polyherbal mixture against non-small-cell lung cancer cells. Journal of Integrative Medicine, 2020, 18(3): 242-252.
[9] Syed Fairus, Hwee Ming Cheng, Kalyana Sundram. Antioxidant status following postprandial challenge of two different doses of tocopherols and tocotrienols. Journal of Integrative Medicine, 2020, 18(1): 68-79.
[10] Gaëtan Olivier Fankem, Michel Archange Fokam Tagne, Paul Aimé Noubissi, Angèle Foyet Fondjo, Idrice Kamtchouing, Adela Ngwewondo, Henri Wambe, Joseph Ngakou Mukam, René Kamgang. Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats. Journal of Integrative Medicine, 2019, 17(6): 438-445.
[11] Rabie Kachkoul, Tarik Squalli Housseini, Mohamed Mohim, RadouaneEl Habbani, Youssef Miyah, Anissa Lahrichi. Chemical compounds as well as antioxidant and litholytic activities of Arbutus unedo L. leaves against calcium oxalate stones. Journal of Integrative Medicine, 2019, 17(6): 430-437.
[12] Fatma Mohamed Hussein Shediwah, Khalid Mohammed Naji, Hussein Saleh Gumaih, Fatima A Alhadi, Amani Lutf Al-Hammami, Myrene Roselyn D'Souza. Antioxidant and antihyperlipidemic activity of Costus speciosus against atherogenic diet-induced hyperlipidemia in rabbits. Journal of Integrative Medicine, 2019, 17(3): 181-191.
[13] Khaled M. M. Koriem, Mahmoud S. Arbid, Hend N. Saleh . Antidiarrheal and protein conservative activities of Psidium guajava in diarrheal rats. Journal of Integrative Medicine, 2019, 17(1): 57-65.
[14] Lucky Legbosi Nwidu, Yibala Ibor Oboma. Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicin-isoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress. Journal of Integrative Medicine, 2019, 17(1): 46-56.
[15] The Su Moe, Htet Htet Win, Thin Thin Hlaing, War War Lwin, Zaw Min Htet, Khin Mar Mya . Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. Journal of Integrative Medicine, 2018, 16(5): 358-366.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278