气郁质与失眠相关性的病例对照研究

doi:10.3736/jcim20120609

Abstract

Objective: To investigate the relationship between insomnia and qi-stagnation by using the international standardized measurement of sleep quality and the Traditional Chinese Medicine (TCM) Constitution Scales.
Methods: A survey by means of the TCM Constitution Scales, the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and the Deep Sleep Scale (DSS) in 169 participants aged between 16 and 80 years old was conducted. Comparison was made to examine the sleep quality and insomnia symptoms in the qi-stagnation group and other-constitution group.
Results: Univariate analysis found that the qi-stagnation group had a significantly increased risk of difficulty in falling asleep (OR=3.012, and 95% CI 1.310 to 6.923 for PSQI; OR=3.016, and 95% CI 1.358 to 6.709 for DSS) and early waking (OR=3.545, and 95% CI 1.229 to 10.232 for PSQI; OR=2.742, and 95% CI 1.072 to 7.014 for DSS), while the other-constitution group had a significant risk of dreaminess (OR=2.419, and 95% CI 1.154 to 5.072 for PSQI; OR=2.561, and 95% CI 1.116 to 5.880 for DSS). A dose-effect relationship existed between insomnia symptoms and qi-stagnation. Qi-stagnation significantly increased the risk of difficulty in falling asleep and early waking.
Conclusion: This case-control study revealed that there is a statistically significant association between qi-stagnation and insomnia. Based on this study, we recommend that further research should be conducted for the rehabilitative care and cure of insomnia from the perspective of TCM constitution.

Key words: sleep initiation and maintenance disorders, physical constitution theory, qi-stagnation, insomnia, scales, case-control studies

Xiao-ling Jiang, Ying Zhang, Ying Lei, Gui-fang Hu, Zheng-gang Zhang, Zhong-ju Xiao. Case-control study on the association between qi-stagnation and insomnia. Journal of Chinese Integrative Medicine, 2012, 10(6): 655-662.

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Index	Normal group (n=60)	Other-constitution group (n=63)	Qi-stagnation group (n=46)	χ² value	P value
Age				3.138	0.791
<25	32	36	28
25 to 39	14	16	12
40 to 59	9	5	3
≥60	2	3	3
Gender				2.210	0.331
Male	26	21	14
Female	34	42	32
Education				4.633	0.592
Senior school or below	10	6	10
Junior college	4	1	5
Undergraduate	36	33	43
Graduate or above	9	6	4
Occupation				2.384	0.304
Student	37	40	35
Non-student	22	22	11

Group	n	Sleep variable
Group	n	PSQI	ESS
Normal	60	54.64	63.34
Other-constitution	63	90.65^**	90.15^**
Qi-stagnation	46	99.00^**	104.49^**

Insomnia subtype	r value
Insomnia subtype	Difficulty in falling asleep	Wake-up during the night	Early morning awakening	Nightmare
Difficulty in falling asleep	1	–	–	–
Wake-up during the night	0.295^△△	1	–	–
Early morning awakening	0.324^△△	0.383^△△	1	–
Nightmare	0.217^△△	0.260^△△	0.108^△△	1

Variable	r value
Variable	Sleep latency	Night awakening time	Early awakening time	Profuse dreaming
Sleep latency	1	–	–	–
Night awakening time	0.285^△△	1	–	–
Early awakening time	0.227^△△	0.295^△△	1	–
Profuse dreaming	0.216^△△	0.271^△△	0.179^△△	1

Group	Difficulty in falling asleep			Early morning awakening			Sleep latency			Early awakening time
Group	–	+	OR	–	+	OR	–	+	OR	–	+	OR
Normal	46	16	–	54	6	–	46	16	–	54	6	–
Qi-stagnation	24	22	–	33	13	–	16	30	–	31	15	–
40 to 54	20	11	1.807	26	5	1.731	12	19	2.547	24	7	1.653
55 to 69	4^*	6^*	4.929	5^**	5^**	9.000	4	6	2.413	5^*	5^*	5.667
70 to 95	0^**	5^**	–	2^**	3^**	13.500	0^*	5^*	–	2^*	3^*	8.500

Case-control study on the association between qi-stagnation and insomnia

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