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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (5): 573-576.doi: 10.3736/jcim20070520

• Original Experimental Research • Previous Articles     Next Articles

In vivo effect of casticin on acute inflammation

Shan Lin1, Hong Zhang1, Ting Han2, Jin-Zhong Wu1, RAHMAN Khalid3, Lu-Ping Qin2   

  1. 1. Department of Pharmacy，Fujian University of Traditional Chinese Medicine，Fuzhou，Fujian Province 350003，China
    2. Department of Pharmacognosy，School of Pharmacy，Second Military Medical University，Shanghai 200433，China
    3. Faculty of Science，School of Biomolecular Sciences，Liverpool John Moores University ，Byrom Street，Liverpool L3 3AF
  • Online:2007-09-20 Published:2007-09-15

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Objective: To investigate the anti-inflammatory effect of casticin of Fructus Viticis.Methods: Observations were made on the anti-inflammatory effect of casticin in the models of acute inflammation in vivo.Results: Casticin inhibited significantly xylene-induced mouse ear edema, egg albumen-induced rat paw edema and acetic acid-induced mouse vascular permeability.Conclusion: Casticin has significant anti-inflammatory effect on acute inflammation, which is probably related to the inhibition of the inflammation factors. Casticin is the effective constituent contributing to the anti-inflammatory effect of Fructus Viticis.

Key words: casticin, Fructus Vi ticis, anti-inflammatory

CLC Number: 

  • R93

Figure 1

Structure of casticin"

Figure 2

Effects of casticin and dexamethasone (DEX) on xylene-induced ear oedema in miceValues are ヌ±S of differences in weight between right and left ears of animals. n=10. *P<0.05 and **P<0.01, compared with control group (one-way ANOVA, LSD as the post hoc test)."

Figure 3

Effects of casticin and dexamethasone (DEX) on acetic acid-induced increased vascular permeability in miceValues are ヌ±S . n=10. *P<0.05 and **P<0.01, compared with control group (one-way ANOVA, LSD as the post hoc test)."

Figure 4

Effects of casticin and dexamethasone（DEX）on egg albumen-induced paw oedema in ratsValues areヌ±S . n=10. *P<0.05 and **P<0.01, compared with control group (one-way ANOVA, LSD as the post hoc test)."

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