Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 33-35.doi: 10.3736/jcim20040112

• Original Experimental Research • Previous Articles     Next Articles

Effects of Xinmailong, Xiangdan and Shenmai Injection on early kidney damage induced by toxin of grass carp bile

Jian-xin Wu, Rong-xiang Niu, Cong-li Dong   

  1. Department of Physiology and Pathophysiology, Dali College, Dali, Yunnan Province 671000,China
  • Online:2004-01-20 Published:2018-10-25

Objective: To observe the effects of Xinmailong (XML), Xiangdan (XD) and Shenmai (SM) Injection on early kidney damage induced by toxin of grass carp bile (GCB) and provide experimental evidence for Chinese medicine in treating toxication of GCB. Methods: GCB (6ml/kg) was administered orally to adult SD rats to induce the model of GCB intoxication and a single intraperitoneal injection of XML, XD or SM was administered 10 min later. Results: It was found that the levels of blood creatinine and blood urea nitrogen were decreased and the creatinine clearance rate was increased by XML, XD or SM. Degenerated epithelial cells of proximal convoluted tubules and glomeruli containing red blood cells in saccular cavities were decreased as compared with the normal group (P <0.01).Conclusion: The Chinese medicine XML, XD and SM Injection have therapeutic effects on early kidney damage induced by toxin of GCB.

Key words: grass carp bile, poisoning, kidney diseases, Xinmailong Injection, Xiangdan Injection, Shenmai Injection

CLC Number: 

  • R595.8

Tab 1

Comparison of BUN, Cr and Ccr in blood of rats of 5 groups (ヌ±S)"

GroupnBUN(mmol/L)Cr(μmol/L)Ccr(ml/min)
Control83.88±1.0256.68±26.850.14±0.04
Model86.02±2.21**132.78±41.02**0.06±0.02**
XML84.28±1.2476.40±24.560.37±0.26△△
XD84.03±0.9262.72±22.320.21±0.08△△
SM84.44±1.1266.40±19.250.30±0.18△△

Tab 2

Changes of renal coefficient and kidney morphology in 5 groups (ヌ±S)"

GroupnRenal coefficient(g/kg)Degenerated epithelial cells in
100 proximal convoluted tubules
Glomeruli containing red blood cells
in saccular cavities in 50 glomeruli
Control84.98±0.722.32±1.353.14±1.34
Model86.62±0.95**16.28±7.62**24.26±8.42**
XML85.20±0.549.40±4.5612.37±3.66△△
XD84.88±0.925.72±6.1211.21±4.08△△
SM85.47±0.497.86±3.2510.30±2.18△△
[1] 周蓉, 王昆兰.急性肾衰竭78例临床分析[J].大理医学院学报,1995,3(8):15-16
[2] 淘凤武, 廖履坦, 徐元钊.鱼胆中毒致多脏器衰竭1例[J].中华内科学杂志,1990,29(2):119
[3] 林碧英. 草鱼胆中毒并多器官功能损害2例[J].国际医药卫生导报,2001,(10):92-93
doi: 10.3760/cma.j.issn.1007-1245.2001.10.123
[4] 孟新科, 邓跃林.鱼胆中毒的研究进展[J].中国危重病急救医学,2000,12(7):437-438
doi: 10.3760/j.issn:1003-0603.2000.07.030
[5] 李树楠, 张华明, 杜一明.心脉龙对大鼠肠系膜微循环的效应观察[J].大理医学院学报,1993,1(1):10-11
[6] 吴建新, 钮荣祥, 王一心.氧自由基在油酸性兔肺损伤中的作用及心脉龙的保护机制[J].中外临床医学杂志,2002,2(5):5-7
[1] Anisur Rahman Khuda-Bukhsh, Antara Banerjee, Surjyo Jyoti Biswas, Susanta Roy Karmakar, Pathikrit Banerjee, Surajit Pathak, Bibhas Guha, Saiful Haque, Debarsi Das, Arnab De, Durba Das, Naoual Boujedaini. An initial report on the efficacy of a millesimal potency Arsenicum Album LM 0/3 in ameliorating arsenic toxicity in humans living in a high-risk arsenic village. Journal of Chinese Integrative Medicine, 2011, 9(6): 596-604.
[2] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074.
[3] Lian-bo Wei, Li-wen Huang. Strategies and methods of integrated traditional Chinese and Western medicine in preventing and treating chronic kidney disease. Journal of Chinese Integrative Medicine, 2008, 6(5): 449-453.
[4] Wei-rong Zhu, Lan Zheng, Yuan-biao Guo, Jian-ming Yuan, Xiao-heng Shen. Clinical research of intraperitoneal chemotherapy plus Shenmai Injection in treating advanced colorectal cancer. Journal of Chinese Integrative Medicine, 2005, 3(4): 266-269.
[5] Shi-da Wu, Jing Wang, Shou-chun Chen, Jun-bo Xu, Qiang Zheng, Ya-fei Yan, Tian-ming Wen, Yan-rong Tang. Effect of Xiangdan Injection on mRNA expression of endothelial vaso-active factors of patients with coronary heart disease and blood stasis. Journal of Chinese Integrative Medicine, 2004, 2(2): 94-96.
[6] Li-qun He. Application of the theory of damp-heat in spleen and stomach in treatment of kidney diseases. Journal of Chinese Integrative Medicine, 2004, 2(1): 7-9.
[7] Xue-mei Zhang, Zhong-hua Zhang. The study of intoxication and toxicity of Fructus Xanthii. Journal of Chinese Integrative Medicine, 2003, 1(1): 71-74.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239