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Journal of Chinese Integrative Medicine ›› 2013, Vol. 11 ›› Issue (3): 184-194.doi: 10.3736/jintegrmed2013031

• Research Article • Previous Articles     Next Articles

Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: A randomized, placebo-controlled trial

Yi Chena, De-yu Fub, Yu Chenb,c, Yan-ming Heb, Xiao-dong Fua, Yan-qiu Xub, Yi Liua, Xiao-tao Fenga, Teng Zhangb,c(), Wen-jian Wanga,c()   

  1. a. Institute of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
    b. Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University ofTraditional Chinese Medicine, Shanghai 200437, China
    c. Clinical Research Institute of Integrative Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai 200437, China
  • Received:2013-03-20 Accepted:2013-04-23 Online:2013-05-10 Published:2013-05-15

Background

Patients with hypertension coupled with metabolic syndrome (MetS) are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebrovascular diseases, it is essential to appropriately control blood pressure together with other cardiovascular risk factors.

Objective

The current study was designed to investigate the therapeutic effects on blood pressure, blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula, a compound traditional Chinese herbal medicine, in addition to routine treatment to hypertensive patients coupled with MetS.


Design, setting, participants and interventions

A total of 43 patients with hypertension coupled with MetS were recruited into this study. The enrolled patients were randomly divided into the Chinese herbal formula group (anti-hypertensive drugs plus Yiqi Huaju Formula, CHF) and the control group (anti-hypertensive drugs plus placebo). The CHF group enrolled 22 patients while the control group received 21 cases. Treatments were given for 12 weeks in both groups.


Main outcome measures

Parameters examined include 24-hour ambulatory blood pressure monitoring, body mass index, waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance (HOMA-IR), fasting glycosylated hemoglobin (HbA1c), fasting plasma glucose, 2-hour postprandial plasma glucose (PPG), fasting plasma insulin, serum lipid, etc.


Results

Compared with the control group, the CHF group had significant improvement (P<0.01) in anthropometric parameters, FPG, HOMA-IR, blood pressure amplitude, blood pressure variability and blood pressure load.


Conclusion

This study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors. The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention.


Trial registration identifier

ChiCTR-TRC-11001633.

Key words: Metabolic syndrome, Hypertension, Ambulatory blood pressure monitoring, Blood pressure variability, Drugs, Chinese herbal, Therapies, Investigational

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Figure 1

Flow chart of this trial24-h ABPM: 24-hour ambulatory blood pressure monitoring; MetS: metabolic syndrome."

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