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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (2): 101-104.doi: 10.3736/jcim20090201

• Original Clinical Research •     Next Articles

Analysis of toxicity of traditional Chinese herbal medicine and its connotation

 Qi Liang,Ming Xie   

  1. Department of Formulaology, Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2008-10-20 Accepted:2008-12-11 Online:2009-02-20 Published:2009-02-15

Based on traditional Chinese medicine theory and clinical experience, traditional Chinese herbal drug toxicity has its own special connotation. From the perspective of history and logic, the different comprehension of toxicity between Western medicine and traditional Chinese medicine was discussed after retracing the meaning of "drug toxicity" in traditional Chinese medicine. The authors suggest that it's not feasible to study the Chinese medicine coping mechanically and applying indiscriminately the concept and the research idea about modern drug toxicity since there is different understanding of "drug toxicity" between traditional Chinese medicine and Western medicine. Many control elements are involved in the use of traditional Chinese herbal drugs, and Chinese drug components and actions are complex as compared with Western drugs. More and more drugs with toxicity will be found due to the relativity of drug toxicity. Currently, the study of Chinese drug toxicity should pay more attention to the relation between the toxicity and Chinese drug nature, compatibility and the corresponding disease or syndrome pattern after making definition of Chinese drug toxicity and its connotation.

Key words: Drug toxicity, Traditional Chinese herbal drug, Chinese medical formula

[1] Zhang TM. Clinical Chinese materia medica[M]. Beijing: China Press of Traditional Chinese Medicine,2004: 63
张廷模 . 临床中药学[M]. 北京: 中国中医药出版社,2004: 63
[2] Ma HM, Zhang BL, Fan YC, Sun JM, Li L . Experimental study of short-term nephrotoxicity in Danggui Sini plus Wuzhuyu Shengjiang Decoction, Aristolochia manshuriensis and Akebia trifoliata stem[J]. Zhong Cao Yao, 1999,30(10):760-762
马红梅, 张伯礼, 范英昌, 孙静美, 李苓 . 当归四逆加吴茱萸生姜汤和关木通、八月札茎短期肾毒性实验研究[J]. 中草药, 1999,30(10):760-762
[3] Li B, Wu ML, Zhou XX, Liang MX . Cause and attenuation methods for toxicity in traditional Chinese herbal medicine[J]. Zhong Yi Za Zhi, 2006,47(10):788-789
李波, 吴美兰, 周昕欣, 梁茂新 . 中药毒性产生的原因及减毒方法[J]. 中医杂志, 2006,47(10):788-789
[4] Bian BL, Si N, Wang HJ, Yang J, He XR . Determination of content changes of toxic components such as aconitine, hypaconitine and mesaconine from decoction of Aconitum carmichaeli decocted separately and decocted with Fritillaria thunbergii[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2006,12(4):9-10
边保林, 司南, 王洪洁, 杨健, 何希荣 . 附子单煎以及与浙贝母合煎后乌头碱、次乌头碱、新乌头碱等有毒成分的含量变化研究[J]. 中国实验方剂学杂志, 2006,12(4):9-10
[5] Zhao XY, Ge WH . Recent advances in mechanism study of eighteen imcompatible pairs[J]. Yunnan Zhong Yi Zhong Yao Za Zhi, 2007,28(8):46-49
赵晓英, 葛卫红 . 中药十八反机制研究进展[J]. 云南中医中药杂志, 2007,28(8):46-49
[6] Gao Y . Toxicity study of traditional Chinese herbal medicine based on enzymes of drug metabolism[J]. Du Li Xue Za Zhi, 2007,21(4):282
高月 . 基于药物代谢酶的中药毒性研究[J]. 毒理学杂志, 2007,21(4):282
[7] Xia LY. Modern toxicology of traditional Chinese herbal medicine[M]. Tianjin: Tianjin Science & Technology Translation & Publishing Corp,2005: 3-5
夏丽英 . 现代中药毒理学[M]. 天津: 天津科技翻译出版公司,2005: 3-5
[8] Li Y, Duan QH . Research progress on toxicity of traditional Chinese herbal medicine[J]. Hai Xia Yao Xue, 2008,20(5):65-67
李永, 段琼辉 . 中药的毒性研究进展[J]. 海峡药学, 2008,20(5):65-67
[9] Wang TS, Xie M . Metabonomics and modern study of traditional Chinese medicine[J]. Zhong Yi Za Zhi, 2006,47(10):723-725
王桐生, 谢鸣 . 代谢组学与中医药现代研究[J]. 中医杂志, 2006,47(10):723-725
[10] Liu SM, Cui LR . Metabonomics and its application prospect in toxicity study of traditional Chinese herbal medicine[J]. Du Li Xue Za Zhi, 2008,22(2):155-158
刘树民, 崔立然 . 代谢组学技术在中药毒性研究中的应用前景[J]. 毒理学杂志, 2008,22(2):155-158
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