四生汤对阴虚证小鼠自由活动能力和血清丙二醛含量的影响

doi:10.3736/jcim20081008

Abstract

Objective:

To assess the therapeutic effects of Sisheng Decoction, a compound traditional Chinese herbal medicine, on a mouse model of yin deficiency syndrome induced by thyroid hormone, and to make the preliminary study on its mechanisms.

Methods:

Simultaneous modeling and treatment were carried out. Sixty mice were randomly divided into six groups: normal group, yin deficiency model group, low-, medium- and high-dose Sisheng Decoction group and Shengmai oral liquid group. Normal group and yin deficiency model group were administered with double distilled water. Spontaneous activity and serum concentration of malondialdehyde in different groups were detected.

Results:

The symptoms of yin deficiency syndrome such as xerostomia, dysphoria and fervescence were improved in the Sisheng Decoction groups. Compared with the yin deficiency model group, the spontaneous activity was increased and the serum concentration of malondialdehyde was decreased in the Sisheng Decoction groups (P<0.05). There was no significant difference between the Sisheng Decoction groups and the Shengmai oral liquid group (P<0.05).

Conclusion:

Medium- or high-dose Sisheng Decoction is effective for nourishing yin, clearing heat, engendering liquid and allaying thirst. The above effects of Sisheng Decoction may be realised by improving the spontaneous activity and resisting oxidative damage.

Key words: Sisheng Decoction, yin deficiency, physical activity, antioxidants, mice

CLC Number:

R730.7

Su-fang Zhang, Zhe Chen, Bai Li, Hong-yun Chen, Chang-quan Ling, Xin-yu Wen. Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency sydrome. Journal of Chinese Integrative Medicine, 2008, 6(10): 1029-1033.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20081008

http://www.jcimjournal.com/EN/Y2008/V6/I10/1029

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Group	n	Average quantity of food (g)	Average quantity of water (ml)
Normal	10	67.62±5.09	47.20±5.73
Yin deficiency model	10	70.92±4.76	56.60±6.54*
Shengmai oral liquid	10	65.53±4.39^△	59.10±9.99*
Low-dose Sisheng Decoction	10	56.82±5.35*^△▲	55.30±8.73*
Medium-dose Sisheng Decoction	10	63.47±5.23^△	53.20±11.57
High-dose Sisheng Decoction	10	63.58±4.19^△	52.50±9.65

Group	n	Day 0	Day 5	Day 10
Normal	10	22.35±1.60	28.95±2.55	33.43±4.24
Yin deficiency model	10	22.50±1.87	28.19±3.47	31.67±4.56
Shengmai oral liquid	10	22.65±1.33	28.80±2.68	32.35±3.29
Low-dose Sisheng Decoction	10	22.85±1.11	27.87±1.64	31.92±2.90
Medium-dose Sisheng Decoction	10	22.90±1.37	28.03±1.83	31.48±1.87
High-dose Sisheng Decoction	10	23.00±1.73	28.12±1.44	32.48±2.94

Group	n	Day 0	Day 5	Day 10
Normal	10	36.96±0.18	37.79±0.43	37.13±0.33
Yin deficiency model	10	36.89±0.53	38.23±0.46*	37.99±0.24*
Shengmai oral liquid	10	36.60±0.74	37.88±0.27	37.52±0.46^△
Low-dose Sisheng Decoction	10	36.87±0.39	37.45±0.37^△▲	37.48±0.53^△
Medium-dose Sisheng Decoction	10	37.16±0.43^▲	37.47±0.45^△▲	37.41±0.53^△
High-dose Sisheng Decoction	10	37.07±0.51^▲	37.52±0.35^△▲	37.45±0.23^△

Group	n	Activity frequency (frequency/5 min)	Activity time (s/5 min)	Average velocity (mm/s)
Normal	10	74.20±9.43	212.87±31.60	22.58±5.73
Yin deficiency model	10	75.80±6.51	166.95±23.84*	14.56±3.21*
Shengmai oral liquid	10	79.90±8.50	170.07±27.95*	14.64±3.69*
Low-dose Sisheng Decoction	10	76.40±12.39	166.76±29.20*	14.17±3.99*
Medium-dose Sisheng Decoction	10	77.00±7.54	215.45±14.02^△▲	22.42±3.08^△▲
High-dose Sisheng Decoction	10	79.60±10.11	208.31±15.08^△▲	20.26±3.31^△▲

Group	n	MDA
Normal	10	1.88±0.32
Yin deficiency model	10	2.91±0.84*
Shengmai oral liquid	10	2.09±0.41^△△
Low-dose Sisheng Decoction	10	2.30±0.48^△
Medium-dose Sisheng Decoction	10	2.05±0.34^△△
High-dose Sisheng Decoction	10	2.19±0.4^△

Effects of Sisheng Decoction on spontaneous activity and serum concentration of malondialdehyde in mice with yin deficiency sydrome

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