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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (4): 281-284.doi: 10.3736/jcim20030415

Special Issue: Acupuncture & Moxibustion

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Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFα in endotoxin shock rats

Hui Li1(), Chun Li2, Shao-hui Du3, Yi-wei Li2, Dong-feng Chen1   

  1. 1. Departmant of Anatomy, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province 510405, China
    2. Nurse College, Guangzhou University of Traditional Chinese Medicine, Guangzhou,Guangdong Province 510405,China
    3. Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong Province 518000, China
  • Received:2003-06-26 Online:2003-12-20 Published:2003-12-20

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Objective

To observe the effect of electro-acupuncture of Neiguan (PC 6) on mean systemic arterial blood pressure and plasmic concentrations of NO and TNFα in endotoxin shock rats.


Methods

The model of endotoxin shock was induced by lipopolysaccharide (1.5 mg/kg i.v.) and D-galactosamine (100 mg/kg i.p.). Aminoguanidine (100 mg/kg i.p.) and electro-acupuncture of bilateral Neiguan (PC 6) were administered. A catheter was inserted into the right subclavian artery to record the change of blood pressure and the blood was abstracted out and centrifuged to determine the NO and TNFα concentrations.


Results

Electro-acupuncture of Neiguan (PC 6) retrieved the blood pressure and reduced the plasmic NO and TNFα concentrations.


Conclusion

Electro-acupuncture of Neiguan (PC 6) expresses an anti-endotoxin shock effect by repressing the plasmic NO and TNFα concentrations smoothly and retrieving the blood pressure stably.

Key words: Neiguan, electro acupuncture, shock, endotoxic, nitric oxide, tumor necrosis factor-alpha

CLC Number: 

  • R245.31

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组别 n 0 min 15 min 30 min 45 min 60 min 90 min 120 min 150 min 180 min
正常组 10 14.3±
1.0		 13.7±
0.8		 13.9±
0.7		 14.0±
1.2		 13.8±
0.6		 13.6±
2.0		 13.7±
1.0		 13.8±
0.8		 13.8±
0.5
模型组 10 13.8±
0.6		 9.5±
0.4**		 10.2±
0.3**		 8.4±
1.0**		 6.3±
0.3**		 6.0±
0.1**		 5.8±
0.5**		 5.8±
1.0**		 5.5±
1.2**
AG组 10 14.2±
0.6		 9.0±
1.1**		 10.0±
1.0**		 11.2±
0.7		 12.3±
1.3ΔΔ		 12.1±
0.8ΔΔ		 13.1±
0.5ΔΔ		 13.6±
1.0ΔΔ		 14.3±
1.2ΔΔ
电针组 10 13.9±
1.2		 8.8±
1.0**		 9.5±
0.8**		 9.2±
0.5**▲		 8.8±
1.3**		 8.6±
0.7*Δ▲		 8±
0.2**Δ▲▲		 8.6±
0.4**▲▲		 8.3±
0.5**Δ▲▲
电针+AG组 10 14.0±
0.8		 9.3±
0.3**		 9.6±
0.7**		 11.0±
0.7		 13.0±
0.4ΔΔ		 12.6±
1.0ΔΔ		 13.0±
0.2ΔΔ		 13.3±
0.6ΔΔ		 13.6±
0.3ΔΔ

"

"

组别 n 0 min 30 min 60 min 90 min 180 min
正常组 10 18.03±1.3 19.22±4.8 20.82±5.5 20.14±4.8 22.94±7.63
模型组 10 17.12±1.5 57.52±10.4** 65.12±10.9** 88.33±9.3** 137.34±11.32
AG组 10 16.80±0.6 51.79±9.5** 24.38±6.7Δ 22.34±9.1ΔΔ 17.21±10.44ΔΔ
电针组 10 16.31±2.1 55.32±14.3** 52.49±15.4 75.91±23.3* 74.55±24.10*Δ▲
电针+AG组 10 17.22±1.1 64.85±11.3** 25.73±10.7Δ 25.45±12.5ΔΔ 28.36±13.4ΔΔ

"

"

组别 n 0 min 30 min 60 min 90 min 180 min
正常组 10 4.3±1.5 4.1±2.1 3.8±1.3 3.7±1.3 4.2±1.7
模型组 10 4.2±1.4 28.5±9.7* 60.4±18.0** 247.0±42.0** 180.0±36.0**
AG组 10 3.9±2.6 30.1±11.2* 65.6±21.8** 260.0±35.0** 210.0±38.0**
电针组 10 3.8±1.9 29.8±10.6* 42.5±20.3* 115.0±33.0**ΔΔ▲▲ 62.5±19.0**ΔΔ▲▲
电针+AG组 10 4.1±2.2 32.2±13.3* 55.7±22.6** 210.0±52.0** 110.0±39.0**Δ
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