电针内关对内毒素休克大鼠血浆一氧化氮及肿瘤坏死因子α浓度的影响

doi:10.3736/jcim20030415

Abstract

Objective

To observe the effect of electro-acupuncture of Neiguan (PC 6) on mean systemic arterial blood pressure and plasmic concentrations of NO and TNFα in endotoxin shock rats.

Methods

The model of endotoxin shock was induced by lipopolysaccharide (1.5 mg/kg i.v.) and D-galactosamine (100 mg/kg i.p.). Aminoguanidine (100 mg/kg i.p.) and electro-acupuncture of bilateral Neiguan (PC 6) were administered. A catheter was inserted into the right subclavian artery to record the change of blood pressure and the blood was abstracted out and centrifuged to determine the NO and TNFα concentrations.

Results

Electro-acupuncture of Neiguan (PC 6) retrieved the blood pressure and reduced the plasmic NO and TNFα concentrations.

Conclusion

Electro-acupuncture of Neiguan (PC 6) expresses an anti-endotoxin shock effect by repressing the plasmic NO and TNFα concentrations smoothly and retrieving the blood pressure stably.

Key words: Neiguan, electro acupuncture, shock, endotoxic, nitric oxide, tumor necrosis factor-alpha

CLC Number:

R245.31

Hui Li, Chun Li, Shao-hui Du, Yi-wei Li, Dong-feng Chen. Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFα in endotoxin shock rats. Journal of Chinese Integrative Medicine, 2003, 1(4): 281-284.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030415

http://www.jcimjournal.com/EN/Y2003/V1/I4/281

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组别	n	0 min	15 min	30 min	45 min	60 min	90 min	120 min	150 min	180 min
正常组	10	14.3± 1.0	13.7± 0.8	13.9± 0.7	14.0± 1.2	13.8± 0.6	13.6± 2.0	13.7± 1.0	13.8± 0.8	13.8± 0.5
模型组	10	13.8± 0.6	9.5± 0.4**	10.2± 0.3**	8.4± 1.0**	6.3± 0.3**	6.0± 0.1**	5.8± 0.5**	5.8± 1.0**	5.5± 1.2**
AG组	10	14.2± 0.6	9.0± 1.1**	10.0± 1.0**	11.2± 0.7	12.3± 1.3^ΔΔ	12.1± 0.8^ΔΔ	13.1± 0.5^ΔΔ	13.6± 1.0^ΔΔ	14.3± 1.2^ΔΔ
电针组	10	13.9± 1.2	8.8± 1.0**	9.5± 0.8**	9.2± 0.5**^▲	8.8± 1.3**	8.6± 0.7*^Δ▲	8± 0.2**^Δ▲▲	8.6± 0.4**^▲▲	8.3± 0.5**^Δ▲▲
电针+AG组	10	14.0± 0.8	9.3± 0.3**	9.6± 0.7**	11.0± 0.7	13.0± 0.4^ΔΔ	12.6± 1.0^ΔΔ	13.0± 0.2^ΔΔ	13.3± 0.6^ΔΔ	13.6± 0.3^ΔΔ

组别	n	0 min	30 min	60 min	90 min	180 min
正常组	10	18.03±1.3	19.22±4.8	20.82±5.5	20.14±4.8	22.94±7.63
模型组	10	17.12±1.5	57.52±10.4**	65.12±10.9**	88.33±9.3**	137.34±11.32
AG组	10	16.80±0.6	51.79±9.5**	24.38±6.7^Δ	22.34±9.1^ΔΔ	17.21±10.44^ΔΔ
电针组	10	16.31±2.1	55.32±14.3**	52.49±15.4	75.91±23.3*	74.55±24.10*^Δ▲
电针+AG组	10	17.22±1.1	64.85±11.3**	25.73±10.7^Δ	25.45±12.5^ΔΔ	28.36±13.4^ΔΔ

组别	n	0 min	30 min	60 min	90 min	180 min
正常组	10	4.3±1.5	4.1±2.1	3.8±1.3	3.7±1.3	4.2±1.7
模型组	10	4.2±1.4	28.5±9.7*	60.4±18.0**	247.0±42.0**	180.0±36.0**
AG组	10	3.9±2.6	30.1±11.2*	65.6±21.8**	260.0±35.0**	210.0±38.0**
电针组	10	3.8±1.9	29.8±10.6*	42.5±20.3*	115.0±33.0**^ΔΔ▲▲	62.5±19.0**^ΔΔ▲▲
电针+AG组	10	4.1±2.2	32.2±13.3*	55.7±22.6**	210.0±52.0**	110.0±39.0**^Δ

Influence of electro-acupuncture of Neiguan on plasmic concentrations of NO and TNFα in endotoxin shock rats

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