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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (2): 153-156.doi: 10.3736/jcim20080209

• Original Clinical Research • Previous Articles     Next Articles

Clinical observation of Yisui Shengxue Granule in treating 25 patients with hemoglobin H disease

Wen-juan Wang1, Zhi-kui Wu1(), Xin-hua Zhang2, Yong-mei Liu1, Su-ping Fang1, Rong-xin Wang2, Chong Zhang1, Tian-hong Zhou2, Ping-ping Li2, Rui-gui Luo2   

  1. 1. Department of Molecular Biology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    2. Department of Haematology, 303 Hospital of Peoples Liberation Army of China, Nanning, Guangxi Zhuang Autonomous Region 530021, China
  • Received:2007-04-09 Online:2008-02-20 Published:2008-02-15
  • Contact: WU Zhi-kui E-mail:gamwuzhikui@sina.com

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Objective:To investigate the clinical efficacy and safety of Yisui Shengxue Granule (YSSXG), a compound traditional Chinese herbal medicine for reinforcing kidney and nourishing blood, in treating hemoglobin H (HbH) disease.

Methods:YSSXG was given orally to 25 patients with HbH disease in Guangxi Zhuang Autonomous Region (high incidence area for HbH disease in China) for 3 months as one therapeutic course, 3 times a day, 10 g YSSXG was given each time (dose of YSSXG for children should be reduced properly), and blood transfusion was not given to HbH patients during the course of treatment. The levels of hemoglobin (Hb), red blood cell (RBC), HbH and reticulocyte (Ret) were observed before and after YSSXG treatment, and side effects were observed during the course of treatment. Meanwhile, the genotype was examined, and the clinical efficacy of YSSXG in treating HbH patients with different genotype was evaluated.

Results:The levels of Hb, RBC and Ret were obviously increased after YSSXG treatment from the first month to the end of treatment (P<0.01). After YSSXG treatment, the levels of Hb, RBC, Ret in 12 HbH patients with gene deletion were elevated (P<0.05, P<0.01), and the levels of Hb and Ret in 13 HbH patients with gene non-deletion were increased obviously (P<0.05, P<0.01). The total response rate was 84% after 3-month treatment, and there was no statistical difference in clinical efficacy between gene deletion HbH patients and non-deletion HbH patients. No adverse effect was observed during the course of treatment.

Conclusion:YSSXG is effective and safe for treatment of HbH disease. YSSXG can improve the levels of Hb, RBC and Ret in HbH patients, especially in gene deletion HbH patients.

Key words: reinforcing kidney and supplying emission, reinforcing qi and nourishing blood, alpha-thalassemia, clinical trials

CLC Number: 

  • R556

Table 1

Changes of blood indexes in HbH patients before and after YSSXG treatment ($\bar{x}$±s)"

Course of treatment n Hb (g/L) RBC (×1012/L) Ret (%) HbH (%)
Before treatment 25 85.32±12.89 4.61±0.75 7.50±3.76 16.85±4.63
After one-month treatment 25 92.36±12.30** 4.80±0.67** 9.54±3.88** 16.99±4.74
After two-month treatment 24 90.50±11.50** 4.79±0.78** 10.33±3.42** 17.09±4.99
After three-month treatment 25 93.64±12.52** 4.87±0.79** 10.32±4.31** 16.26±4.23

Table 2

Changes of blood indexes in HbH patients with gene deletion before and after YSSXG treatment ($\bar{x}$±s)"

Course of treatment n Hb (g/L) RBC (×1012/L) Ret (%) HbH (%)
Before treatment 12 90.33±11.76 5.08±0.57 4.71±1.85 14.69±5.41
After one-month treatment 12 96.92±10.86* 5.31±0.38* 6.36±1.78** 14.90±5.78
After two-month treatment 11 96.73±7.35** 5.35±0.45** 7.53±1.92** 14.94±5.99
After three-month treatment 12 100.08±8.70** 5.43±0.42* 7.13±2.36** 14.03±4.34

Table 3

Changes of blood indexes in HbH patients with gene non-deletion before and after YSSXG treatment ($\bar{x}$±s)"

Course of treatment n Hb (g/L) RBC (×1012/L) Ret (%) HbH (%)
Before treatment 13 80.69±12.53 4.17±0.64 10.08±3.19 18.85±2.64
After one-month treatment 13 88.15±12.44** 4.33±0.51 12.48±2.78** 18.93±2.41
After two-month treatment 13 85.23±11.95 4.31±0.67 12.69±2.48** 18.91±3.17
After three-month treatment 13 87.69±12.82* 4.35±0.70 13.27±3.54** 18.32±2.99
[1] Zhang ZN. Diagnosis and curative effect evaluation standard of hematopathy. Beijing: Science Press. 1998: 48-59. Chinese.
张之南 . 血液病诊断及疗效标准.北京: 科学出版社. 1998: 48-59.
[2] State Bureau of Technical Supervision. Clinical terminology of traditional Chinese medical diagnosis and treatment of syndromes. Beijing: Standards Press of China. 1997: 2-3, 33-35, 37-40. Chinese.
国家技术监督局. 中华人民共和国国家标准中医临床诊疗术语证候部分.北京: 中国标准出版社.1997: 2-3, 33-35, 37-40.
[3] Zheng XY. Guiding principle of clinical research on Chinese new drugs. Beijing: Chinese Medical Science and Technology Press. 2002: 173- 184, 263-266. Chinese.
郑筱萸 . 中药新药临床研究指导原则.北京: 中国医药科技出版社. 2002: 173- 184, 263-266.
[4] Zhang JW, Long GF. Hemoglobin and hemoglobin disease. Nanning: Guangxi Science and Technology Press. 2003: 204-213. Chinese.
张俊武, 龙桂芳 . 血红蛋白与血红蛋白病.南宁: 广西科学技术出版社. 2003: 204-213.
[5] Zhou YQ, Xiao QZ, Huang LJ , et al. Clinical phenotype genotype correlation in children with hemoglobin H Disease in Zhuhai area of China. Zhonghua Er Ke Za Zhi. 2004; 42(9):693-696. Chinese with abstract in English.
周玉球, 肖奇志, 黄丽娟 , 等. HbH病患儿临床表现与基因型相关性的研究.中华儿科杂志. 2004; 42(9):693-696.
[6] Wu ZK, Zhang XH, Li M , et al. Clinical observation on effects of Yisui Shengxue Granule in treating 156 patients with p-thalassemia. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(4):352-354. Chinese with abstract in English.
doi: 10.7661/CJIM.2006.4.352
吴志奎, 张新华, 李敏 , 等. 益髓生血颗粒治疗卩-地中海贫血156例临床观察.中国中西医结合杂志. 2006; 26(4):352-354.
doi: 10.7661/CJIM.2006.4.352
[7] Wu ZK, Zhang XH, Cai HG , et al. Molecular mechanism of Yisui Shengxue Granule in treating patients with β-thalassemia and regulating the expression of globin mRNA. Yi Xue Yan Jiu Za Zhi. 2006; 35(9):36-37. Chinese.
doi: 10.3969/j.issn.1673-548X.2006.09.013
吴志奎, 张新华, 蔡辉国 , 等. 益髓生血颗粒治疗地贫与调控珠蛋白mRNA表达分子机制研究.医学研究杂志. 2006; 35(9):36-37.
doi: 10.3969/j.issn.1673-548X.2006.09.013
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