益髓生血颗粒治疗血红蛋白H病25例临床观察

doi:10.3736/jcim20080209

Abstract

Objective:To investigate the clinical efficacy and safety of Yisui Shengxue Granule (YSSXG), a compound traditional Chinese herbal medicine for reinforcing kidney and nourishing blood, in treating hemoglobin H (HbH) disease.

Methods:YSSXG was given orally to 25 patients with HbH disease in Guangxi Zhuang Autonomous Region (high incidence area for HbH disease in China) for 3 months as one therapeutic course, 3 times a day, 10 g YSSXG was given each time (dose of YSSXG for children should be reduced properly), and blood transfusion was not given to HbH patients during the course of treatment. The levels of hemoglobin (Hb), red blood cell (RBC), HbH and reticulocyte (Ret) were observed before and after YSSXG treatment, and side effects were observed during the course of treatment. Meanwhile, the genotype was examined, and the clinical efficacy of YSSXG in treating HbH patients with different genotype was evaluated.

Results:The levels of Hb, RBC and Ret were obviously increased after YSSXG treatment from the first month to the end of treatment (P<0.01). After YSSXG treatment, the levels of Hb, RBC, Ret in 12 HbH patients with gene deletion were elevated (P<0.05, P<0.01), and the levels of Hb and Ret in 13 HbH patients with gene non-deletion were increased obviously (P<0.05, P<0.01). The total response rate was 84% after 3-month treatment, and there was no statistical difference in clinical efficacy between gene deletion HbH patients and non-deletion HbH patients. No adverse effect was observed during the course of treatment.

Conclusion:YSSXG is effective and safe for treatment of HbH disease. YSSXG can improve the levels of Hb, RBC and Ret in HbH patients, especially in gene deletion HbH patients.

Key words: reinforcing kidney and supplying emission, reinforcing qi and nourishing blood, alpha-thalassemia, clinical trials

CLC Number:

R556

Wen-juan Wang, Zhi-kui Wu, Xin-hua Zhang, Yong-mei Liu, Su-ping Fang, Rong-xin Wang, Chong Zhang, Tian-hong Zhou, Ping-ping Lu, Rui-gui Luo. Clinical observation of Yisui Shengxue Granule in treating 25 patients with hemoglobin H disease. Journal of Chinese Integrative Medicine, 2008, 6(2): 153-156.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080209

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Course of treatment	n	Hb (g/L)	RBC (×10¹²/L)	Ret (%)	HbH (%)
Before treatment	25	85.32±12.89	4.61±0.75	7.50±3.76	16.85±4.63
After one-month treatment	25	92.36±12.30**	4.80±0.67**	9.54±3.88**	16.99±4.74
After two-month treatment	24	90.50±11.50**	4.79±0.78**	10.33±3.42**	17.09±4.99
After three-month treatment	25	93.64±12.52**	4.87±0.79**	10.32±4.31**	16.26±4.23

Course of treatment	n	Hb (g/L)	RBC (×10¹²/L)	Ret (%)	HbH (%)
Before treatment	12	90.33±11.76	5.08±0.57	4.71±1.85	14.69±5.41
After one-month treatment	12	96.92±10.86*	5.31±0.38*	6.36±1.78**	14.90±5.78
After two-month treatment	11	96.73±7.35**	5.35±0.45**	7.53±1.92**	14.94±5.99
After three-month treatment	12	100.08±8.70**	5.43±0.42*	7.13±2.36**	14.03±4.34

Course of treatment	n	Hb (g/L)	RBC (×10¹²/L)	Ret (%)	HbH (%)
Before treatment	13	80.69±12.53	4.17±0.64	10.08±3.19	18.85±2.64
After one-month treatment	13	88.15±12.44**	4.33±0.51	12.48±2.78**	18.93±2.41
After two-month treatment	13	85.23±11.95	4.31±0.67	12.69±2.48**	18.91±3.17
After three-month treatment	13	87.69±12.82*	4.35±0.70	13.27±3.54**	18.32±2.99

Clinical observation of Yisui Shengxue Granule in treating 25 patients with hemoglobin H disease

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