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Journal of Integrative Medicine ›› 2016, Vol. 14 ›› Issue (1): 1-4.doi: 10.1016/S2095-4964(16)60242-X

• Commentary •     Next Articles

A novel treatment for weight reduction by the recombinant “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin”

MahsaJalilia, ZahraBazib, AzitaHekmatdoosta   

  1. a Clinical Nutrition Department, Nutrition Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    b Medical Biotechnology Department, Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Received:2015-08-14 Accepted:2015-11-09 Online:2016-01-15 Published:2016-01-15
  • Contact: Zahra Bazi; Tel: +98-2123781; E-mail:

Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of “Pichia pastoris” yeast expressing the hybrid protein of “irisin-furin-transferrin” under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.

Key words: Obesity, Nutrition, Biotechnology, DNA, Recombinant

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