,Phlai,Antihistamine,Skin test,Rhinitis,Allergic,Loratadine," /> ,Phlai,Antihistamine,Skin test,Rhinitis,Allergic,Loratadine,"/> Inhibitory effect of <em>Phlai</em> capsules on skin test responses among allergic rhinitis patients: A randomized, three-way crossover study
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (6): 462-468.doi: 10.1016/S2095-4964(17)60353-4

• Research Article • Previous Articles     Next Articles

Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients: A randomized, three-way crossover study

Pattara Tanticharoenwiwata,b, Prapasri Kulalerta,b, Thaweephol Dechatiwongse Na Ayudhyac, Sittichai Koontongkaewc,d, Weena Jiratchariyakule, Ruedee Soawakonthaf, Prakongsiri Booncongg, Orapan Poachanukoona,b,c   

  1. a Center of Excellence for Allergy, Asthma and Pulmonary Disease, Thammasat University Hospital,Pathumthani 12120, Thailand 
    b Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand 
    c Medicinal Herb Research Unit for Asthma, Faculty of Medicine, Thammasat University, Pathumthani 12120,Thailand 
    d Faculty of Dentistry, Thammasat University, Pathumthani 12120, Thailand 
    e Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand 
    f Faculty of Pharmaceutical Sciences, Huachiew Chalermprekiet University, Samut Prakan 10540, Thailand;
    g Department for Development of Thai Traditional and Alternative Medicine, Ministry of Public Health,Nonthaburi 11000, Thailand
  • Received:2017-02-16 Accepted:2017-04-24 Online:2017-11-15 Published:2017-11-15
  • Contact: Prof. Orapan Poachanukoon; E-mail: orapanpoachanukoon@yahoo.com


Zingiber cassumunar Roxb., commonly known as Phlai in Thai, has been used as a traditional medicine in Thailand for the treatment of various diseases, including inflammation and chronic airway disease.


The purpose of this study was to assess the antihistaminic effect of Phlai on skin testing.

Design, Setting, Participants and Intervention

This was a randomized, open-label, three-way crossover study. Twenty allergic rhinitis (AR) patients were enrolled. In randomized sequence, patients received a single dose of Phlai capsules (100 or 200 mg) or loratadine (10 mg) with a washout period of 1 week between each treatment.

Main Outcome Measures

Skin prick testing for histamine and common aeroallergen (house dust mite) were performed before treatment and after 1, 2, 3, 4, 6, 8, 12 and 24 hours of treatment. The main treatment outcomes were the mean wheal and flare responses to the skin prick test after treatment.


Both 100 mg and 200 mg Phlai doses suppressed wheal and flare responses to house dust mite allergen, but only 200 mg of Phlai capsules significantly suppressed wheal and flare responses to histamine. Repeated measures analysis of variance showed that loratadine caused more wheal and flare suppression than Phlai capsules in responses to the histamine skin prick test. However, there were no significant differences among the effects of 100 mg Phlai capsules, 200 mg Phlai capsules and loratadine in suppression of wheal and flare induced by the mite skin prick test. Both doses of Phlai were well-tolerated with no adverse events.


Both 100 mg (compound D 4 mg) and 200 mg (compound D 8 mg) Phlai capsules, when taken as a single therapeutic dose, inhibited skin reactivity to histamine and mite skin prick tests in AR patients.

Trial Registration

Thai clinical trial registry (TCTR20160510001).

Key words: Zingiber cassumunar, Phlai, Antihistamine, Skin test, Rhinitis, Allergic, Loratadine

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