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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (5): 407-410.doi: 10.3736/jcim20090502

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Relationship between lupus headache and headache due to internal injury in traditional Chinese medicine

Si-yu Shena,Xiao-dong Fub,Yong-wen Zhanga, Xiao-lei Donga,Ling-jie Zhaoa,Hui Caia   

  1. a Department of Integrated Traditional Chinese and Western Medicine,Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, Jiangsu Province, China
    b Institute of Chinese Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2009-01-22 Accepted:2009-03-17 Online:2009-05-20 Published:2009-05-15

In 1999, the nomenclature and case definitions for neuropsychiatric lupus syndromes were published by American College of Rheumatology (ACR), and the cognition of neuropsychiatric damage of systemic lupus erythematosus (SLE) was gradually unified and standardized. Lupus headache is an intractable problem in SLE, especially in SLE patients complicated with multiple organ injury. In general, vascular headache is common in most SLE patients, and a small number of SLE patients complicated with nervous headache are found in clinic. Moreover, its pathophysiological mechanism is far from being understood. Although early diagnosis is essential for good outcomes, the diagnosis method is rather confused in the world. There still exist some limitations in the proposal of clinical classification of headache from ACR and International Headache Society (IHS), and the proposal does not mention the classification of headache related to psychiatric damage. Current therapeutic regimens are almost exclusively based on empirical evidence. Treatment approaches include symptomatic treatment, immunosuppressive, anticoagulant and anti-aggregant therapies. It provides enormous and hopeful space in research of combined therapy strategy, especially in the field of traditional Chinese medicine. The authors discussed the relationship between lupus headache and headache due to internal injury in the view of integrated traditional Chinese and Western medicine, and suggested that the treatment strategy for lupus headache should be made in argument with the headache due to internal injury. Syndrome differentiation treatment according to deficiency in the root and excess in the branch and the therapy for activating blood to dredge collaterals maybe have great advantages in treatment of the headache in SLE.

Key words: Systemic lupus erythematosus, Neuropsychiatric systemic lupus erythematosus, Headache, Collateral disease, Traditional Chinese medicine

[1] Hanly JG . ACR classification criteria for systemic lupus erythematosus: limitations and revisions to neuropsychiatric variables[J]. Lupus, 2004,13(11):861-864
doi: 10.1191/0961203304lu2024oa
[2] Shen SY, Zhang YW, Dong XL, Zhao LJ, Cai H . Biochemical marker of brain damage in neuropsychiatric lupus[J]. Zhonghua Feng Shi Bing Xue Za Zhi, 2007,11(5):316-317
沈思钰, 张永文, 董晓蕾, 赵凌杰, 蔡辉 . 神经精神狼疮脑损害标志物的分析[J]. 中华风湿病学杂志, 2007,11(5):316-317
[3] Shen SY, Kong WD, Cai H . New advances of neuroimaging in diagnosis of neuropsychiatric lupus[J]. Zhonghua Feng Shi Bing Xue Za Zhi, 2007,11(4):250-253
沈思钰, 孔伟东, 蔡辉 . 神经精神狼疮的神经影像学诊断新进展[J]. 中华风湿病学杂志, 2007,11(4):250-253
[4] Mitsikostas DD, Sfikakis PP, Goadsby PJ . A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth[J]. Brain, 2004,127(5):1200-1209
doi: 10.1093/brain/awh146
[5] Omdal R, Waterloo K, Koldingsnes W, Husby G, Mellgren SI . Somatic and psychological features of headache in systemic lupus erythematosus[J]. J Rheumatol, 2001,28(4):772-779
[6] Davey R, Bamford J, Emery P . The ACR classification criteria for headache disorders in SLE fail to classify certain prevalent headache types[J]. Cephalalgia, 2008,28(3):296-299
doi: 10.1111/j.1468-2982.2007.01510.x
[7] Shen SY, Kong WD, Zhang YW, Dong XL, Zhao LJ, Cai H . Obstructive hydrocephalus and systemic lupus erythematosus: a case report[J]. Zhonghua Feng Shi Bing Xue Za Zhi, 2007,11(9):574-575
沈思钰, 孔伟东, 张永文, 董晓蕾, 赵凌杰, 蔡辉 . 系统性红斑狼疮并发阻塞性脑积水一例[J]. 中华风湿病学杂志, 2007,11(9):574-575
[8] Wu YL . Exploration of pathogenesis of collateral disease in traditional Chinese medicine[J]. Zhong Yi Za Zhi, 2005,46(4):243-245
吴以岭 . 络病病机探析[J]. 中医杂志, 2005,46(4):243-245
[9] Hanly JG, Harrison MJ . Management of neuro-psychiatric lupus[J]. Best Pract Res Clin Rheumatol, 2005,19(5):799-821
doi: 10.1016/j.berh.2005.04.003
[10] Trevisani VF, Castro AA, Neves Neto JF, Atallah AN .Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus[J].Cochrane Database Syst Rev, 2006,( 2):CD002265
[11] Shen SY, Zhang YW, Yao RB, Dong XL, Guo JH, Hu B, Zhao LJ, Cai H . Relationship between collateral disease theory in traditional Chinese medicine and crisis of systemic lupus erythematosus[J]. Guiyang Zhong Yi Xue Yuan Xue Bao, 2007,29(2):6-8
沈思钰, 张永文, 姚茹冰, 董晓蕾, 郭郡浩, 胡兵, 赵凌杰, 蔡辉 . 中医络病理论与系统性红斑狼疮危象的证治关系[J]. 贵阳中医学院学报, 2007,29(2):6-8
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