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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 184-186.doi: 10.3736/jcim20030311

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Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer

Zhe Chen1, Xiao-feng Zhai1, Yong-hua Su1, Xu-ying Wan1, Jin Li1, Jue-min Xie2, Bo Gao2   

  1. 1. Department of Traditional Chinese Medicine, Changhai Hospital,Second Military Medical University, Shanghai 200433, China
    2. Anhui Jinchan Pharmaceutical Group,Huaibei, Anhui Province 235000, China
  • Received:2003-04-24 Online:2003-09-20 Published:2003-09-20

Objective

To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer (PLC).


Methods

One hundred patients with moderate and advanced PLC were randomly divided into cino-treated group (50 patients) and control group (50 patients). The quality of life, tumor size, some changes of laboratory tests, and survival time were observed.


Results

The progressive rate of cino-treated group (18%) was lower than that of the control group (32%). The quality of life of the cino-treated group (80%) was better than that of the control group (72%), but witbout statistical significance. The survival rate of >12 months of the cino-treated group (30%) was higher than that of the control group (18%). The patients' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group. The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group.


Conclusion

Cinobufacini injection can not only inhibit the proliferation of cancer, but also protect liver function, improve quality of life and prolong survival time.

Key words: cinobufacini, therapy, carcinoma, hepatocytes

CLC Number: 

  • R730.52

"

组别 n 改善
例数
稳定
例数
恶化
例数
总有效率(%)
华蟾素治疗组 50 15 25 10 80
一般治疗组 50 13 23 14 72

"

组别 n CR PR NC PD
华蟾素治疗组 50 0 1 40 9
一般治疗组 50 0 0 34 16

"

组别 n WBC(×109) TBIL(μmol/L) ALT(U/L) AFP(μg/L)
华蟾素治疗组 治疗前
治疗后
50
50
4.31±0.56
4.64±0.61
43.5±9.12
32.8±7.91*
77.6±11.52
61.4±10.09*
866.4±151.33
891.7±165.47
一般治疗组 治疗前
治疗后
50
50
4.51±0.58
4.32±0.57
37.4±8.32
54.6±9.97*
84.2±12.76
101.4±14.37*
903.7±190.66
1 310.2±211.29*

"

组别 n 3个月 6个月 12个月 >12个月
华蟾素治疗组 50 39 31 17 15
一般治疗组 50 40 29 10 9
[1] 中华人民共和国卫生部医政司. 中国常见恶性肿瘤诊治规范,第二分册:原发性肝癌(第1版)[M]. 北京: 北京医科大学中国协和医科大学联合出版社, 1990,( 第1版):1
[2] 汤钊猷, 余业勤 . 原发性肝癌(第2版)[M]. 上海: 上海科学技术出版社, 1999,( 第2版):271-278
[3] 张振玉, 张昆和, 王崇文 , 等. 华蟾素对三种消化系统肿瘤细胞杀伤机制的研究[J]. 中药药理与临床, 1999,15(5):28-29
doi: 10.3969/j.issn.1001-859X.1999.05.014
[4] 巫善明, 徐向田, 徐伟民 , 等. 华蟾素抗鸭乙型肝炎病毒实验研究[J]. 中华传染病杂志, 1995,13(1):25-26
[5] 徐向田, 荆培棠, 李永华 , 等. 华蟾素治疗慢性乙型肝炎病毒携带者临床研究[J]. 中国中西医结合杂志, 1993,13(8):473-475
[6] 赵兴梅, 陈晓明, 杨祖贻 , 等. 华蟾素注射液对人IL-2水平及LAK细胞活性的影响[J]. 中药药理与临床, 1995,15(6):33-35
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