华蟾素注射液治疗中晚期原发性肝癌临床疗效观察

doi:10.3736/jcim20030311

Abstract

Objective

To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer (PLC).

Methods

One hundred patients with moderate and advanced PLC were randomly divided into cino-treated group (50 patients) and control group (50 patients). The quality of life, tumor size, some changes of laboratory tests, and survival time were observed.

Results

The progressive rate of cino-treated group (18%) was lower than that of the control group (32%). The quality of life of the cino-treated group (80%) was better than that of the control group (72%), but witbout statistical significance. The survival rate of >12 months of the cino-treated group (30%) was higher than that of the control group (18%). The patients' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group. The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group.

Conclusion

Cinobufacini injection can not only inhibit the proliferation of cancer, but also protect liver function, improve quality of life and prolong survival time.

Key words: cinobufacini, therapy, carcinoma, hepatocytes

CLC Number:

R730.52

Zhe Chen, Xiao-feng Zhai, Yong-hua Su, Xu-ying Wan, Jin Li, Jue-min Xie, Bo Gao. Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer. Journal of Chinese Integrative Medicine, 2003, 1(3): 184-186.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030311

http://www.jcimjournal.com/EN/Y2003/V1/I3/184

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组别	n	CR	PR	NC	PD
华蟾素治疗组	50	0	1	40	9
一般治疗组	50	0	0	34	16

组别		n	WBC（×109）	TBIL（μmol/L）	ALT（U/L）	AFP（μg/L）
华蟾素治疗组	治疗前治疗后	50 50	4.31±0.56 4.64±0.61	43.5±9.12 32.8±7.91*^△	77.6±11.52 61.4±10.09*^△	866.4±151.33 891.7±165.47^△
一般治疗组	治疗前治疗后	50 50	4.51±0.58 4.32±0.57	37.4±8.32 54.6±9.97*	84.2±12.76 101.4±14.37*	903.7±190.66 1 310.2±211.29*

Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer

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组别	n	改善例数	稳定例数	恶化例数	总有效率（%）
华蟾素治疗组	50	15	25	10	80
一般治疗组	50	13	23	14	72

组别	n	3个月	6个月	12个月	>12个月
华蟾素治疗组	50	39	31	17	15
一般治疗组	50	40	29	10	9