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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 184-186.doi: 10.3736/jcim20030311

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Clinical observation of cinobufacini injection used to treat moderate and advanced primary liver cancer

Zhe Chen1, Xiao-feng Zhai1, Yong-hua Su1, Xu-ying Wan1, Jin Li1, Jue-min Xie2, Bo Gao2   

  1. 1. Department of Traditional Chinese Medicine, Changhai Hospital,Second Military Medical University, Shanghai 200433, China
    2. Anhui Jinchan Pharmaceutical Group,Huaibei, Anhui Province 235000, China
  • Received:2003-04-24 Online:2003-09-20 Published:2003-09-20


To observe the clinical effect of cinobufacini injection in treating moderate and advanced primary liver cancer (PLC).


One hundred patients with moderate and advanced PLC were randomly divided into cino-treated group (50 patients) and control group (50 patients). The quality of life, tumor size, some changes of laboratory tests, and survival time were observed.


The progressive rate of cino-treated group (18%) was lower than that of the control group (32%). The quality of life of the cino-treated group (80%) was better than that of the control group (72%), but witbout statistical significance. The survival rate of >12 months of the cino-treated group (30%) was higher than that of the control group (18%). The patients' liver function such as serum total bilirubin and ALT decreased obviously in the cino-treated group while increased a lot in the control group. The level of AFP increased after treatment with statistical significance in the control group while there was no statistical significance in the cino-treated group.


Cinobufacini injection can not only inhibit the proliferation of cancer, but also protect liver function, improve quality of life and prolong survival time.

Key words: cinobufacini, therapy, carcinoma, hepatocytes

CLC Number: 

  • R730.52


组别 n 改善
华蟾素治疗组 50 15 25 10 80
一般治疗组 50 13 23 14 72


组别 n CR PR NC PD
华蟾素治疗组 50 0 1 40 9
一般治疗组 50 0 0 34 16


组别 n WBC(×109) TBIL(μmol/L) ALT(U/L) AFP(μg/L)
华蟾素治疗组 治疗前
一般治疗组 治疗前
1 310.2±211.29*


组别 n 3个月 6个月 12个月 >12个月
华蟾素治疗组 50 39 31 17 15
一般治疗组 50 40 29 10 9
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