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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (1): 49-52.doi: 10.3736/jcim20040118

• Original Experimental Research • Previous Articles     Next Articles

Experimental study on Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis

Yong-jian Li   

  1. Department of Oncology, Suzhou Hospital of Traditional Chinese Medicine,Suzhou,Jiangsu Province 215003,China
  • Online:2004-01-20 Published:2018-10-25

Objective: To study the effect of Qi-replenishing and Yin-nourishing in inhibiting tumor metastasis. Methods: Fifty mice were randomly divided into replenishing Qi group, replenishing Yin group, replenishing Qi and Yin group, chemotherapy group and control group. Models of Lewis lung cancer and B16 melanoma were observed in vivo. The tumor weight inhibiting rate, metastatic lung tumor, concentrations of t-PA and TXB2 in tumor tissue and IL-2 and TNF-α in spleen were observed. Results: The tumor weight inhibiting rates of replenishing Qi and Yin group for Lewis lung cancer and B16 melanoma were both 42.9%. Replenishing Qi and Yin could decrease the contents of TXB2 and 6-keto-PGF1α, and increase the levels of IL-2 and TNF-α.Conclusion: Replenishing Qi and Yin can promote the healthy energy to inhibiting tumor metastasis.

Key words: replenishing Qi and Yin, carcinoma, neoplasm metastasis, drugs, Chinese herbal, animals, laboratory

CLC Number: 

  • R730.52

Tab 1

Comparison of tumor weight and inhibiting rate in mice of 5 groups (ヌ±S)"

Group n Lewis lung cancer B16 melanoma
Tumor weight(g) Inhibiting rate(%) Tumor weight(g) Inhibiting rate(%)
Replenishing Qi 10 1.9±0.6** 45.7 1.6±0.3** 42.9
Replenishing Yin 10 2.7±0.7 22.9 2.4±0.6 14.1
Replenishing Qi and Yin 10 2.0±0.4** 42.9 1.6±0.4** 42.9
Chemotherapy 10 3.4±0.9 2.9 2.4±0.5 14.3
Control 10 3.5±1.0 2.8±0.5

Tab 2

Comparison of number of metastatic tumor and inhibiting rate in mice of 5 groups (ヌ±S)"

Group n Lewis lung cancer B16 melanoma
Tumor weight(g) Inhibiting rate(%) Tumor weight(g) Inhibiting rate(%)
Replenishing Qi 10 9.8±2.2 22.8 19.5±4.1 11.4
Replenishing Yin 10 9.2±2.1 27.6 14.6±5.3** 33.6
Replenishing Qi and Yin 10 8.7±2.7* 31.5 13.9±4.1** 36.8
Chemotherapy 10 10.4±2.6 18.1 22.0±6.8 1.8
Control 10 12.7±3.1 22.4±5.8

Tab 3

Comparison of concentration of TXB2, t-PA and 6-Keto-PGF1α of tumor in mice of 5 groups (ヌ±S, pg/g)"

Group n Lewis lung cancer B16 melanoma
TXB2 t-PA 6-Keto-PGF1α TXB2 t-PA 6-Keto-PGF1α
Replenishing Qi 10 185.8±14.7 97.75±7.2** 45.9±27.4 92.7±31.2* 23.3±2.1** 63.1±5.2*
Replenishing Yin 10 157.2±45.6* 82.37±18.5* 44.7±24.6 82.7±3.5** 18.8±1.5 53.2±2.9**
Replenishing Qi and Yin 10 131.7±40.1** 104.10±10.3** 39.3±26.7 70.3±36.2** 22.1±2.9** 50.4±19.8**
Chemotherapy 10 195.3±38.9 49.25±9.2 50.4±19.8 114.2±19.6 18.1±1.5 66.3±4.5
Control 10 206.5±27.3 40.2 ±16.1 55.6±22.4 115.1±14.8 15.7±1.4 69.7±5.8

Tab 4

Comparison of concentration of IL-2 and TNF-α of spleen in mice of 5 groups (ヌ±S, ng/g)"

Group n Lewis lung cancer B16 melanoma
IL-2 TNF-α IL-2 TNF-α
Replenishing Qi 10 0.30±0.13* 0.15±0.11* 0.19±0.05 0.13±0.02*
Replenishing Yin 10 0.25±0.08* 0.12±0.06 0.23±0.09* 0.09±0.07*
Replenishing Qi and Yin 10 0.24±0.06* 0.23±0.14* 0.23±0.06* 0.23±0.13**
Chemotherapy 10 0.18±0.08 0.07±0.04 0.16±0.07 0.04±0.01
Control 10 0.18±0.03 0.09±0.05 0.15±0.04 0.03±0.02
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