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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (2): 111-114.doi: 10.3736/jcim20040210

• Original Experimental Research • Previous Articles     Next Articles

Effect of Zhenju Jiangya Tablet on the endothelial function of hyperlipidemic rabbits

Xu-min Hou, Huan-chun Ni, Xin-ping Luo, Hai-ming Shi, Wei-hu Fan   

  1. Department of Cardiology, Huashan Hospital, Fudan University, Shanghai 200040,China
  • Online:2004-03-20 Published:2018-10-25

Objective: To study the effect of Zhenju Jiangya Tablet (ZJ) on the injured endothelial cells and endothelium-dependent relaxation function of hyperlipidemia rabbits. Methods: Male New Zealand rabbits were randomized into four groups: control group, hyperlipidemia group, ZJ group and sivastatin group. The endothelium-dependent relaxation function was evaluated by APV using intravascular Doppler, and the morphology of endothelial cells was detected by light microscopy and electron microscopy, and nitric oxide synthase was evaluated. Results: ZJ reduced the lesions of hyperlipidemia vessels, and the APV after Ach injection of each group was (1.14±0.26), (1.74±0.59), (1.22±0.37) and (1.17±0.41) respectively. The eNOS of each group was (4.21±0.37), (1.43±0.88), (3.95±0.67) and (4.08±0.46) nmol·min-1·g-1 respectively. Conclusion: ZJ can improve the abnormality of endothelial cells and endothelium-dependent relaxation function of hyperlipidemia.

Key words: Zhenju Jiangya Tablet, endothelium, hyperlipidemia, ultrasonography, Doppler, nitric oxide

CLC Number: 

  • R589.21

Tab 1

Effects of high fat diet on blood lipid of rabbit and effects of different drugs (ヌ±S,mmol/L)"

TimeGroupnTGTCHDL-CLDL-C
End of the 1st week
Control101.85±0.231.67±0.510.37±0.050.43±0.11
Hyperlipidemia101.39±0.451.26±0.110.38±0.120.40±0.08
ZJ Tablet treated101.21±0.481.47±0.520.35±0.140.42±0.13
Sivastatin treated101.51±0.181.31±0.060.36±0.110.44±0.16
End of the 5th week
Control101.76±0.381.33±0.210.38±0.290.45±0.16
Hyperlipidemia103.75±0.14*28.86±0.30*1.57±0.34*11.68±0.44*
ZJ Tablet treated103.77±0.18*28.80±0.56*1.78±0.49*14.98±0.53*
Sivastatin treated103.61±0.33*28.54±0.25*1.63±0.12*13.58±0.35*
End of the 10th week
Control101.49±0.251.25±0.140.32±0.090.34±0.25
Hyperlipidemia103.48±0.16*29.16±0.01*1.74±0.42*12.76±0.26*
ZJ Tablet treated103.46±0.41*26.23±0.65*1.53±0.16*10.86±0.28*
Sivastatin treated101.76±0.8110.42±0.950.74±0.366.73±0.63

Figure 1

Morphology of endothelial cells detected by light microscopyA. Control group (HE,×200); B. Hyperlipidemia group (HE,×100); C. ZJ Tablet treated group (HE,×100); D. Sivastatin treated group (HE,×400)"

Figure 1

Morphology of endothelial cells detected by electron microscopyA. Control group; B. Hyperlipidemia group; C. ZJ Tablet treated group; D. Sivastatin treated group"

Tab 2

Effects of hyperlipidemia and the different treatment on blood velocity (ヌ±S,cm/s)"

GroupnAPV value
2 min post-Ach2 min post-NTG
Control101.14±0.261.08±0.37
Hyperlipidemia101.74±0.591.13±0.26
ZJ Tablet treated101.22±0.37*1.10±0.18
Sivastatin treated101.17±0.41*1.12±0.28

Tab 3

Effects of hyperlipidemia and the different treatment on eNOS (ヌ±S,nmol·min-1·g-1)"

GroupneNOS
Control104.21±0.37
Hyperlipidemia101.43±0.88*
ZJ Tablet treated103.95±0.67
Sivastatin treated104.08±0.46
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doi: 10.1016/S0006-2952(00)00352-X pmid: 10874128
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