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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (1): 28-30.doi: 10.3736/jcim20050109

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Treatment of lower limb ischemia with combination of traditional Chinese medicine and transplantation of autologous bone marrow mononuclear cells: A report of 23 cases

Bo-hua Yang,Jian-hui Qin,Ling-qun Zhu,Lei Chen,Hong Lu,Feng-tong Liu,You-shan Li   

  1. Department of Vascular Surgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700, China
  • Received:2004-08-08 Online:2005-01-20 Published:2005-01-20
  • Contact: Bo-hua Yang E-mail:yangb5191@sina.com

Objective

To evaluate the therapeutic effect of transplantation of autologous bone marrow mononuclear cells combined with traditional Chinese medicine for the treatment of limb ischemia.

Methods

Twenty-three patients with limb ischemia were treated. G-CSF was used to stimulate the bone marrow. The mononuclear cells were separated from the aspirated bone marrow fluid in the stem cell studio. The cell amount was above 1×109. The transplantation was performed by the way of intra-muscular multi-injection. Traditional Chinese medicine for replenishing qi to activate blood was prescribed from the first day after operation. The pain, poikilothermia, ulcer or necrosis and ankle/brachial index (ABI) of the ischemic limb were evaluated before and after the treatment.

Results

The pain score and poikilothermia score decreased one month after the transplantation, with distinct differences as compared with the scores before the treatment (P<0.05). The ABI increased gradually after the treatment, and one month after the treatment, it was 0.15 higher than that before the treatment.

Conclusion

Transplantation of autologous bone marrow mononuclear cells combined with traditional Chinese medicine can decrease the symptoms and signs of severe lower limb ischemia effectively, and improve the circulation of the ischemic area.

Key words: Bone marrow transplantation, Monocytes, Lower limb ischemia, Traditional Chinese medicine treatment

CLC Number: 

  • R364.12

Tab 1

Pain score, poikilothermia score and ABI before and after treatment ($\bar{x}$±s)"

Time n Pain score Poikilothermia score ABI
Before treatment 23 3.44±0.77 3.33±0.76 0.280±0.23
1 week after treatment 23 2.00±0.71 2.00±0.94 0.312±0.22
2 weeks after treatment 23 2.25±1.12 2.25±1.00 0.372±0.23
1 month after treatment 23 1.33±0.73* 1.67±0.70* 0.402±0.18*
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