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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (5): 408-410.doi: 10.3736/jcim20050521

• Review • Previous Articles     Next Articles

Progress in research on phytoestrogens and their effect targets

Shu-fang Shi,Chao-qin Yu   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2004-10-11 Online:2005-09-20 Published:2005-09-20
  • Contact: Chao-qin Yu

Key words: Estrogens, Effect target, Estrogen receptor

CLC Number: 

  • R347.913
[1] Rose VL . AAP issues recommendations for the use of soy protein-based formulas in infant feeding[J]. Am Fam Physician, 1998,57(11):2876
doi: 10.1093/fampra/15.5.431 pmid: 9636345
[2] Green S, Walter P, Kumar V , et al. Human oestrogen receptor cDNA: Sequence, expression and homology to v-erb A[J]. Nature, 1986,320(6058):134-139
doi: 10.1038/320134a0 pmid: 3754034
[3] Kuiper GG, Enmark E, Pelto-Huikko M , et al. Cloning of a novel receptor expressed in rat prostate and ovary[J]. Proc Natl Acad Sci U S A, 1996,93(12):5925-5930
doi: 10.1073/pnas.93.12.5925 pmid: 8650195
[4] Pace P, Taylor J, Suntharalingam S , et al. Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha[J]. J Biol Chem, 1997,272(41):25832-25838
doi: 10.1074/jbc.272.41.25832
[5] Ogawa S, Inoue S, Watanabe T , et al. The complete primary structure of human estrogen receptor beta(hERbeta) and its heterodimerization with ER alpha in vivo and in vitro[J]. Biochem Biophys Res Commun, 1998,243(1):122-126
doi: 10.1006/bbrc.1997.7893
[6] Tremblay GB, Tremblay A, Copeland NG , et al. Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta[J]. Mol Endocrinol, 1997,11(3):353-365
doi: 10.1210/mend.11.3.9902 pmid: 9058381
[7] 李艳, 张平安 . 雌激素受体β的研究进展[J]. 国外医学·临床生物化学与检验学分册, 2002,23(4):214-215
[8] Giguere V, Tremblay A, Tremblay GB . Estrogen receptor beta: re-evaluation of estrogen and antiestrogen signaling[J]. Steroids, 1998,63(5-6):335-339
doi: 10.1016/S0039-128X(98)00024-5 pmid: 9618797
[9] 张吉强, 蔡文琴 . 雌激素β受体研究进展[J]. 生理科学进展, 2001,32(1):68-70
doi: 10.7666/d.y488474
[10] 张吉强, 姚青, 蔡文琴 . 雌激素β受体免疫阳性物质在生后不同发育时期小鼠基底前脑的表达研究[J]. 第三军医大学学报, 2002,24(8):889-891
[11] Mowa CN, Iwanaga T . Differential distribution of oestrogen receptor-alpha and beta mRNAs in the female reproductive organ of rats as revealed by in situ hybridization[J]. J Endocrinol, 2000,165(1):59-66
doi: 10.1677/joe.0.1650059
[12] Wilson ME, Rosewell KL, Kashon ML , et al. Age differentially influences estrogen receptor-alpha(ERalpha) and estrogen receptor-beta(ERbeta) gene expression in specific regions of the rat brain[J]. Mech Ageing Dev, 2002,123(6):593-601
doi: 10.1016/S0047-6374(01)00406-7
[13] Koike S, Sakai M, Muramatsu M . Molecular cloning and characterization of rat estrogen receptor cDNA[J]. Nucleic Acids Res, 1987,15(6):2499-2513
doi: 10.1093/nar/15.6.2499
[14] Weisz A, Rosales R . Identification of an estrogen response element upstream of the human c-fos gene that binds estrogen receptor and the AP-1 transcription factor[J]. Nucleic Acids Res, 1990,18(17):5097-5106
doi: 10.1093/nar/18.17.5097
[15] Katzenellenbogen JA, OMalley BW, Katzenellenbogen BS . Tripartite steroid hormone receptor pharmacology:interaction with multiple effector sites as a basis for cell- and promoter-specific action of these hormones[J]. Mol Endocrinol, 1996,10(2):119-131
[16] Paech K, Webb P, Kuiper GG , et al. Differential ligand activation of estrogen receptors ER alpha and ER beta at AP1 sites[J]. Science, 1997,277(5331):1508-1510
doi: 10.1126/science.277.5331.1508 pmid: 9278514
[17] Evans RM . The steroid and thyroid hormone receptor superfamily[J]. Science, 1988,240(4854):889-895
doi: 10.1126/science.3283939 pmid: 3283939
[18] Kuiper GG, Lemmen JG, Carlsson B , et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta[J]. Endocrinology, 1998,139(10):4252-4263
doi: 10.1210/endo.139.10.6216
[19] 余文三 . 植物雌激素研究进展[J]. 国外医学·卫生分册, 1999,26(2):84-87
[20] Peterson G, Barnes S . Genistein and biochanin A inhibit the growth of human prostate cancer cells but not epidermal growth factor receptor tyrosine autophosphorylation[J]. Prostate, 1993,22(4):335-345
doi: 10.1002/(ISSN)1097-0045
[21] Wiseman H . The therapeutic potential of phytoestrogens[J]. Expert Opin Investig Drugs, 2000,9(8):1829-1840
doi: 10.1517/13543784.9.8.1829 pmid: 11060780
[22] Adlercreutz H . Phytoestrogens and breast cancer[J]. J Steroid Biochem Mol Biol, 2002,83(1-5):113-118
doi: 10.1016/S0960-0760(02)00273-X
[23] Glazier MG, Bowman MA . A review of evidence for the use of phytoestrogens as replacement for traditional estrogen replacement therapy[J]. Arch Intern Med, 2001,161(9):1161-1172
doi: 10.1001/archinte.161.9.1161
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