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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (2): 147-151.doi: 10.3736/jcim20060208

• Original Clinical Research • Previous Articles     Next Articles

Pharmacokinetic characteristics of ferulic acid in patients with different syndromes of deficiency of spleen qi, stagnation of liver qi and spleen deficiency, and excess of stomach heat

Ping Ren1, Xi Huang2, Shuang-qing Li1, Shu-yun Xu3, Mei-hua Wan2, Ya-xiong Zhou3, Yi-wu Zhou3, Wen-fu Tang2   

  1. 1. Department of General Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    2. Department of Integrated Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
    3. Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
  • Online:2006-03-20 Published:2006-03-15

Objective

To investigate the nature of syndrome of traditional Chinese medicine by means of pharmacokinetic (PK) method.

Methods

Twenty-one healthy volunteers, 20 patients with syndrome of stagnation of liver qi and spleen deficiency, 22 patients with syndrome of deficiency of spleen qi and 19 patients with syndrome of excess of stomach heat were included and administered to take Jiawei Xiaoyaosan Recipe (JWXYSR). The serum PK parameters of ferulic acid (FA) were examined by high performance liquid chromatography (HPLC) method. 

Results

The absorption rate constant (α) and the elimination rate constant (β) were both decreased while the apparent first-order absorption constant (Ka) was enhanced significantly in the patients with syndrome of deficiency of spleen qi; the α, β and Ka were all reduced in the patients with syndrome of stagnation of liver qi and spleen deficiency; the β and Ka were increased in the patients with syndrome of excess of stomach heat, as compared with the corresponding PK parameters in the healthy volunteers (P<0.01).

Conclusion

The PK analysis of FA in the patients with syndrome of deficiency of spleen qi shows that the absorption rate is accelerated, and both the distribution and elimination rates are slowed down. The absorption, distribution and elimination rates of AF are all slowed down in the patients with syndrome of stagnation of liver-qi and spleen deficiency, while the absorption and elimination rates of AF are both accelerated in the patients with syndrome of excess of stomach heat. There are obvious differences in the PK characteristics among these three syndromes.

Key words: Syndrome of deficiency of spleen qi, Syndrome of stagnation of liver qi and spleen deficiency, Syndrome of excess of stomach heat, Ferulic acid, Pharm

CLC Number: 

  • R285.6

Figure 1

HPLC results of ferulic acid (FA) in different serum samplesA: Blank control serum sample from healthy person; B: FA and p-hydroxybenzaldehyde-treated serum sample from healthy person; C: Jiawei Xiaoyaosan Recipe (JWXYSR)-treated serum sample from patient; a: FA; b: p-hydroxybenzaldehyde."

Figure 2

Ultraviolet spectrograms of FA in different serum samplesA: FA and p-hydroxybenzaldehyde-treated serum sample from healthy person; B: JWXYSR-treated serum sample from patient."

Table 1

Serum concentrations of FA at different time in healthy persons and the patients with different syndromes after taking JWXYSR (ヌ±S, μg/L)"

Time after takingSerum concentration
JWXYSR (min)Healthy group (n=21)DSQ group (n=22)SLQSD group (n=20)ESH group (n=19)
5104.38±23.9126.77±6.6110.64±1.48116.38±58.23
10140.12±30.3349.70±7.0322.81±4.86130.47±63.59
15152.94±36.1162.39±6.9138.49±5.39109.34±41.67
30131.76±27.2676.95±10.3952.30±8.9386.39±24.18
60100.19±22.8738.00±9.9833.76±3.2853.27±16.36
9095.73±47.3927.65±6.5021.58±3.5529.12±8.41
12087.29±18.4716.57±3.2918.45±5.1717.78±3.66

Table 2

Pharmacokinetics parameters of serum FA in healthy persons and the patients with different syndromes after taking JWXYSR (ヌ±S)"

Pharmacokinetics parameterValue
Healthy group (n=21)DSQ group (n=22)SLQSD group (n=20)ESH group (n=19)
α (min–1)0.093±0.0220.041±0.014**0.058±0.021**0.095±0.610
β (min–1)0.005 4±0.003 10.002 7±0.001 2**0.003 1±0.010 2**0.011 0±0.008 1**
Ka (min–1)0.38±0.120.82±0.12**0.19±0.01**0.71±0.02**
t1/2α (min)7.63±1.4519.48±0.78**13.54±1.95**7.95±0.88**
t1/2Ka (min)19.40±6.8029.58±8.76**3.61±1.77**0.77±6.96**
K21 (min–1)0.037±0.0010.013±0.023**0.018±0.030**0.038±0.052
K10 (min–1)0.019±0.1000.009 4±0.001**0.008 1±0.010**0.021±0.020
K12 (min–1)0.044±0.0010.022±0.001**0.032±0.0010.039±0.001
AUC [(μg·L–1)·min]20 201.31±1 900.0916 741.72±7 000.51**15 570.11±6 350.60**19 086.31±7 490.81
tp (min)12.35±10.4026.04±0.72**37.29 ±14.78**10.74±20.10
Cmax (μg·L–1)160.98±6.3078.25±9.45**57.47±8.59**136.73±5.83
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