益气平喘颗粒治疗气虚寒哮证支气管哮喘急性发作的随机对照试验

doi:10.3736/jcim20070105

Abstract

Objective: To evaluate the safety and efficacy of Yiqi Pingchuan Granule in treating acute attack of asthma due to qi deficiency and cold syndrome.

Methods: A randomized controlled trial was conducted. A total of 80 patients with an acute attack of asthma were included. They were allocated into two groups randomly in a ratio of three to one. Sixty patients in the treatment group received Yiqi Pingchuan Granule and 20 patients in the control group received Ruyi Dingchuan Pill. Patients in both groups were treated for 7 days.

Results: There were no significant differences in traditional Chinese medicine syndrome, clinical symptoms and lung function between the two groups (P>0.05). After treatment, the forced expiratory volume in 1 second was increased in the treatment group (P＜0.05), and the peak expiratory flow was accelerated in the control group (P＜0.05). No significant side effects were noted in both groups.

Conclusion: Yiqi Pingchuan Granule is safe and effective in treating acute attack of asthma due to qi deficiency and cold syndrome.

Key words: herbal preparations, randomized controlled trials, bronchial spasm, asthma

CLC Number:

R562.25

Ying Zhang, Rui-ming Zhang, Jing Chang, Ting-qian Li, Huan-hai Cui, Bing Mao, Guang-yuan Chen, Wen-fu Tang, Lei Wang, Su-zhen Huang. A randomized controlled trial of Yiqi Pingchuan Granule in treating acute attack of bronchial spasm due to asthma of qi deficiency and cold syndrome. Journal of Chinese Integrative Medicine, 2007, 5(1): 23-27.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20070105

http://www.jcimjournal.com/EN/Y2007/V5/I1/23

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Item	Treatment group	Control group	Statistic	P
Case	60	20
Sex (M/F)	18/42	5/15	0.616	0.433
Average age (ヌ±S , year)	49.48±11.72	46.65±13.50	0.901	0.370
Course of disease (M, month)	232.5	128.5	–1.473	0.141
Course of asthma attacks (1 d / 2 d / 3 d)	6/29/25	2/13/5	1.117	0.264
Severity (mild/moderate)	25/35	8/12	0.117	0.896
Accumulated score of TCM symptoms and signs (?x±s)	18.88±5.92	18.10±5.79	0.515	0.608
FEV1 (ヌ±S , L)	1.64±0.90	1.85±0.77	0.915	0.363
PEF (ヌ±S , L/s)	3.83±2.13	4.39±1.95	1.050	0.297

Item	Group	n	FEV1 (L/s)
Control
Pre-treatment	20	1.85±0.77	4.39±1.95
Post-treatment	20	1.98±0.89a	4.70±2.19b
Treatment
Pre-treatment	60	1.64±0.90	3.83±2.13
Post-treatment	60	1.76±0.92c, e	4.03±2.09d, f

A randomized controlled trial of Yiqi Pingchuan Granule in treating acute attack of bronchial spasm due to asthma of qi deficiency and cold syndrome

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