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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 28-31.doi: 10.3736/jcim20070106

• Original Clinical Research • Previous Articles     Next Articles

Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis

Guo-lin Peng1, Xiao-yun Zhang2   

  1. 1.Department of Gastroenterology, Yingtan 184 Hospital, Yingtan, Jiangxi Province 335000, China
    2. Department of Laboratory Diagnostics, Yingtan 184 Hospital, Yingtan, Jiangxi Province 335000, China
  • Online:2007-01-31 Published:2007-01-21

Objective: To study the effects of Salvia miltiorrhiza on serum levels of cytokines including interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) in patients with severe acute pancreatitis (SAP). 

Methods: Thirty-six SAP patients were randomly divided into Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group with eighteen patients in each group. Fourteen age-matched healthy volunteers were assigned to control group. Serum levels of IL-6, IL-8, and TNF-α were tested within 24 hours of admission and 7 days after admission. 

Results: Compared with those of the healthy volunteers, serum levels of the three cytokines of the SAP patients were significantly elevated (P<0.05). Serum levels of the three cytokines were significantly decreased in both Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group after 7-day treatment (P<0.05). The declining of the serum levels of the three cytokines in Salvia miltiorrhiza-treated group was more obvious than that in non-Salvia miltiorrhiza-treated group.

Conclusion: Salvia miltiorrhiza can treat SAP patients by reducing the serum levels of IL-6, IL-8, and TNF-α.

Key words: Salvia miltiorrhiza, cytokine, pancreatitis

CLC Number: 

  • R969

Table 1

Serum levels of IL-6, IL-8 and TNF-α in three groups ($\bar{x}±S$,g/L)"

Salvia miltiorrhiza-treated
Before treatment1879.25±6.01*98.78±16.59*27.01±1.49*
After treatment1829.12±4.0234.56±1.2617.13±1.28
Non-Salvia miltiorrhiza-treated
Before treatment1881.25±6.01*93.78±16.59*25.01±1.49*
After treatment1854.25±6.0150.78±9.5918.01±1.49
[1] Rattner DW, Legermate DA, Lee MJ, et al.Early surgical debridement of symptomatic pancreatic necrosis is beneficial irrespective of infection[J].Am J Surg,1992,163(1):105-109,110
[2] Uomo G, Visconti M, Manes G, et al.Nonsurgical treatment of acute necrotizing pancreatitis[J].Pancreas,1996,12(2):142-148
doi: 10.1097/00006676-199603000-00006 pmid: 8720660
[3] Bank S, Singh P, Pooran N, et al.Evaluation of factors that have reduced mortality from acute pancreatitis over the past 20 years[J].J Clin Gastroenterol,2002,35(1):50-60
[4] Hartwig W, Maksan SM, Foitzik T, et al.Reduction in mortality with delayed surgical therapy of severe pancreatitis[J].J Gastrointest Surg,2002,6(3):481-487
doi: 10.1016/S1091-255X(02)00008-2 pmid: 12023003
[5] 王自法, 徐军, 潘承恩, 等.地塞米松抑制炎症递质改善鼠重症急性胰腺炎的预后[J].世界华人消化杂志,2000,8(2):239
doi: 10.3969/j.issn.1009-3079.2000.02.043
Wang ZF, Xu J, Pan CE, et al.Dexamethasone improves prognosis of severe acute pancreatitis in rats by inhibiting inflammatory mediators[J]. Shi Jie Hua Ren Xiao Hua Za Zhi ,2000,8(2):239.Chinese
doi: 10.3969/j.issn.1009-3079.2000.02.043
[6] Sandoval D, Gukovskaya A, Reavey P, et al.The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis[J].Gastroenterology,1996,111(4):1081-1091
[7] Di Giovine FS, Stones S, Duff GW.Cytokines: identification and measurement of gene activation. Tumor immunobiology: a practical approach(第2版)[M].New York: IRL Press,1995,(第2版):159-175
[8] 中华医学会消化病学分会胰腺疾病学组.国急性胰腺炎诊治指南(草案)[J].胰腺病学,2004,4(1):35-38
doi: 10.3760/cma.j.issn.1674-1935.2004.01.012
Group of Pancreatopathy, Branch Association for Diseases of Digestive System, Chinese Medical Association.Draft criteria for diagnosis and treatment of acute pancreatitis in China[J].Yi Xian Bing Xue,2004,4(1):35-38
doi: 10.3760/cma.j.issn.1674-1935.2004.01.012
[9] Kusske AM, Rongione AJ, Reber HA.Cytokines and acute pancreatitis[J].Gastroenterology,1996,110(2):639-642
[10] Steinberg W, Tenner S.Acute pancreatitis[J].N Engl J Med,1994,330(17):1198-1220
[11] Inagaki T, Hoshino M, Hayakawa T, et al.Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis[J].Pancreas,1997,14(1):1-8
doi: 10.1097/00006676-199701000-00001 pmid: 8981500
[12] Ji X, Tan BK, Zhu YC, et al.Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats[J].Life Sci,2003,73(11):1413-1426
[13] 沙建平, 祝彼得, 赵艳, 等.丹参对兔重症急性胰腺炎早期中性粒细胞与内皮细胞粘附机制的研究[J].国中西医结合消化杂志,2004,12(1):3-5
doi: 10.3969/j.issn.1671-038X.2004.01.001
Sha JP, Zhu PD, Zhao Y, et al.Effect of Salvia miltiorrhiza on inhibiting polymorphonuclear leukocyte and endothelial cells adhesion in rabbits with severe acute pancreatitis of early stage[J].Zhongguo Zhong Xi Yi Jie He Xiao Hua Za Zhi,2004,12(1):3-5
[14] 李雷, 王桂敏, 蒋俊明, 等.丹参对重症急性胰腺炎早期多器官组织脂质过氧化的影响[J].中国中西医结合消化杂志,2005,13(1):1-3
Li L, Wang GM, Jiang JM, et al.Effect of Salvia miltiorrhiza on lipid peroxidation of multiple organs in rats with severe acute pancreatitis of early stage[J].Zhongguo Zhong Xi Yi Jie He Xiao Hua Za Zhi,2005,13(1):1-3
[15] Baggiolini M, Loetscher P, Moser B.Interleukin-8 and the chemokine family[J].Int J Immunopharmacol,1995,17(2):103-108
doi: 10.1016/0192-0561(94)00088-6 pmid: 7657403
[16] Gross V, Andreesen R, Leser HG, et al.Interleukin-8 and neutrophil activation in acute pancreatitis[J].Eur J Clin Invest,1992,22(3):200-203
doi: 10.1111/j.1365-2362.1992.tb01826.x pmid: 1582445
[17] Dinarello CA.Biologic basis for interleukin-1 in disease[J].Blood,1996,87(6):2095-2147
[18] 李振江, 陈威, 徐月清, 等.重症急性胰腺炎患者HV-CVVH清除细胞因子的作用[J].第四军医大学学报,2004,25(9):846-848
doi: 10.3321/j.issn:1000-2790.2004.09.023
Li ZJ, Chen W, Xu YM, et al.Clearance effects of high volume continuous veno-venous hemofiltration on cytokines in patients with severe acute pancreatitis[J].Di Si Jun Yi Da Xue Xue Bao,2004,25(9):846-848
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