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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 28-31.doi: 10.3736/jcim20070106

• Original Clinical Research • Previous Articles     Next Articles

Effects of Salvia miltiorrhiza on serum levels of inflammatory cytokines in patients with severe acute pancreatitis

Guo-lin Peng1, Xiao-yun Zhang2   

  1. 1.Department of Gastroenterology, Yingtan 184 Hospital, Yingtan, Jiangxi Province 335000, China
    2. Department of Laboratory Diagnostics, Yingtan 184 Hospital, Yingtan, Jiangxi Province 335000, China
  • Online:2007-01-31 Published:2007-01-21

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Objective: To study the effects of Salvia miltiorrhiza on serum levels of cytokines including interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) in patients with severe acute pancreatitis (SAP). 

Methods: Thirty-six SAP patients were randomly divided into Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group with eighteen patients in each group. Fourteen age-matched healthy volunteers were assigned to control group. Serum levels of IL-6, IL-8, and TNF-α were tested within 24 hours of admission and 7 days after admission. 

Results: Compared with those of the healthy volunteers, serum levels of the three cytokines of the SAP patients were significantly elevated (P＜0.05). Serum levels of the three cytokines were significantly decreased in both Salvia miltiorrhiza-treated group and non-Salvia miltiorrhiza-treated group after 7-day treatment (P＜0.05). The declining of the serum levels of the three cytokines in Salvia miltiorrhiza-treated group was more obvious than that in non-Salvia miltiorrhiza-treated group.

Conclusion: Salvia miltiorrhiza can treat SAP patients by reducing the serum levels of IL-6, IL-8, and TNF-α.

Key words: Salvia miltiorrhiza, cytokine, pancreatitis

CLC Number: 

  • R969

Table 1

Serum levels of IL-6, IL-8 and TNF-α in three groups （$\bar{x}±S$,g/L）"

GroupnIL-6IL-8TNF-α
Salvia miltiorrhiza-treated
Before treatment1879.25±6.01*98.78±16.59*27.01±1.49*
After treatment1829.12±4.02△34.56±1.26△17.13±1.28△
Non-Salvia miltiorrhiza-treated
Before treatment1881.25±6.01*93.78±16.59*25.01±1.49*
After treatment1854.25±6.01△50.78±9.59△18.01±1.49△
Control1413.90±1.8625.35±1.5415.14±1.36
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