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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (6): 645-649.doi: 10.3736/jcim20080620

• Literature Review • Previous Articles     Next Articles

Research on pharmacology, toxicology and safety of Semen Strychni: review and prospect

Zhen-hua Guo, Hong-mei Ma(), Bo-li Zhang   

  1. Chinese Medicine Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2007-10-24 Online:2008-06-20 Published:2008-06-15
  • Contact: MA Hong-mei E-mail:mahongmeihao@126.com

Key words: Semen Strychni, pharmacology, toxicology, safety

CLC Number: 

  • R96
[1] Wang QW, Liu L, Huang GZ . Study of toxicology of strychnos[J]. Fa Yi Xue Za Zhi, 2004,20(3):183-184
doi: 10.3969/j.issn.1004-5619.2004.03.019
王琦玮, 刘良, 黄光照 . 马钱子的毒理学研究进展[J]. 法医学杂志, 2004,20(3):183-184
doi: 10.3969/j.issn.1004-5619.2004.03.019
[2] Cai BC, Wu H, Yang XW , et al. Analysis of spectral data for 13CNMR of sixteen strychnos alkaloids[J]. Yao Xue Xue Bao, 1994,29(1):44-48
蔡宝昌, 吴皓, 杨秀伟 , 等. 马钱子中16个生物碱类化合物13CNMR谱的数据分析[J]. 药学学报, 1994,29(1):44-48
[3] Huang XR, Cao D . Research advancement of Semen Strychni[J]. Shanghai Zhong Yi Yao Za Zhi, 2005,39(1):62-65
黄喜茹, 曹冬 . 马钱子研究进展[J]. 上海中医药杂志, 2005,39(1):62-65
[4] Yin W, Cai BC . Clinical and pharmacology research progress of Semen Strychni[J]. Jiangsu Zhong Yi, 2000,21(7):42-44
殷武, 蔡宝昌 . 马钱子临床与药理研究进展[J]. 江苏中医, 2000,21(7):42-44
[5] Wei SC, Xu LJ, Zhang XQ . Effect of crude alkaloid of Semen Strychni on adjuvant arthritis in rat[J]. Zhongguo Yao Li Xue Tong Bao, 2001,17(4):479-480
doi: 10.3321/j.issn:1001-1978.2001.04.035
魏世超, 徐丽君, 张秀桥 . 马钱子总生物碱对大鼠佐剂性关节炎的作用[J]. 中国药理学通报, 2001,17(4):479-480
doi: 10.3321/j.issn:1001-1978.2001.04.035
[6] Zhou AX, Guo SY, Tian JL , et al. Effects of compound prescription Semen Strychni Tablet on immunologic function[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 1998,4(4):46-48
周爱香, 郭淑英, 田甲丽 , 等. 复方马钱子片对免疫功能的影响[J]. 中国实验方剂学杂志, 1998,4(4):46-48
[7] Lu YM, Chen L, Cai BC , et al. Single channel analysis and electron micrography study on myocardial effects of isobrucine[J]. Yao Xue Xue Bao, 1995,30(3):168-171
陆跃鸣, 陈龙, 蔡宝昌 . 异马钱子碱对心肌细胞作用的单钙通道及透射电镜分析[J]. 药学学报, 1995,30(3):168-171
[8] Li MH, Zhao DH, Zhang GQ . Effect of brucine on the action potentials in guinea pig papillary muscles[J]. Zhongguo Yao Li Xue Bao, 1997,13(3):157-159
李明华, 赵德华, 张贵卿 . 马钱子碱对豚鼠心脏乳头肌动作电位的影响[J]. 中国药理学报, 1997,13(3):157-159
[9] Lu YM, Chen L, Cai BC , et al. Comparison of brucine and nitrogen oxides isobrucine in their anti-cancer and anti-oxidation effect[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao, 1998,14(6):349-351
陆跃鸣, 陈龙, 蔡宝昌 , 等. 马钱子碱与异马钱子碱氮氧化物抗肿瘤细胞生长及抗氧化损伤作用的比较[J]. 南京中医药大学学报, 1998,14(6):349-351
[10] Song AY, Zhang GL, Liu SJ , et al. Experimental research of anti-cancer effect of Semen Strychni[J]. Zhongguo Zhong Yi Yao Ke Ji, 2004,11(6):363
doi: 10.3969/j.issn.1005-7072.2004.06.039
宋爱英, 张国烈, 刘松江 , 等. 马钱子抗肿瘤作用的实验研究[J]. 中国中医药科技, 2004,11(6):363
doi: 10.3969/j.issn.1005-7072.2004.06.039
[11] Zhang H, Li YL, Ren LS , et al. Tumorostatic activity of nux vomica and Rhizoma Arisaematis on murine transplanted tumor H22[J]. Zhongguo Yao Wu Yu Lin Chuang, 1997,13(2):157-159
doi: 10.3969/j.issn.1671-2560.2005.04.009
张蕻, 李燕玲, 任连生 , 等. 马钱子天南星对小鼠移植性肿瘤H22的抑瘤作用[J]. 中国药物与临床, 1997,13(2):157-159
doi: 10.3969/j.issn.1671-2560.2005.04.009
[12] Zhang M, Li P, Chen ZH , et al. Effects of brucine on nitric oxide induced apoptosis in chondrocyte[J]. Zhongguo Lin Chuang Kang Fu, 2003,7(26):3554-3555
张梅, 李平, 陈朝晖 , 等. 马钱子碱对一氧化氮诱导软骨细胞凋亡的影响[J]. 中国临床康复, 2003,7(26):3554-3555
[13] Zhou AX, Yao XZ, Shen H , et al. Analgesia function and toxicology experiment of the compound prescription nux-vomica[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 1998,4(4):59-60
周爱香, 姚祥珍, 沈鸿 , 等. 复方马钱子片的镇痛作用和毒理试验[J]. 中国实验方剂学杂志, 1998,4(4):59-60
[14] Zhu JW, Wu JB, Li CS , et al. Study of the analgesia function and pharmacodynamics of brucine[J]. Zhongguo Zhong Yi Yao Ke Ji, 2005,12(3):166-167
朱建伟, 武继彪, 李成韶 , 等. 马钱子碱镇痛作用及其药效动力学研究[J]. 中国中医药科技, 2005,12(3):166-167
[15] Wu YF, Lin JM, Zheng LP , et al. The effect of strychnos nuxvomica processed in three different ways on blood serum SOD and testosterone in mice[J]. Fujian Zhong Yi Xue Yuan Xue Bao, 2004,14(2):24-25
doi: 10.3969/j.issn.1004-5627.2004.02.010
吴奕富, 林久茂, 郑良朴 , 等. 3种不同炮制的马钱子对小鼠血清超氧化物歧化酶和睾酮的影响[J]. 福建中医学院学报, 2004,14(2):24-25
doi: 10.3969/j.issn.1004-5627.2004.02.010
[16] Zhao ZD, Huang ZS . Advance in toxic action and side effect of Semen Strychni[J]. Guo Yi Lun Tan, 2003,18(1):50-51
doi: 10.3969/j.issn.1002-1078.2003.01.049
赵珍东, 黄兆胜 . 马钱子的毒副作用研究进展[J]. 国医论坛, 2003,18(1):50-51
doi: 10.3969/j.issn.1002-1078.2003.01.049
[17] Li BJ . One case of dysphrenia caused by poison effect of Semen Strychni[J]. Shannxi Zhong Yi, 1995,16(7):314
李宝君 . 马钱子中毒致精神障碍1例[J]. 陕西中医, 1995,16(7):314
[18] Wang JZ, Ma XM . Acupuncture and moxibustion in treatment of eight cases of double side facial nerve paralysis caused by poison effect of Semen Strychni[J]. Zhong Yi Yao Xue Bao, 1998,26(4):33
王敬祖, 马雪梅 . 针灸治疗马钱子中毒引起双侧面神经麻痹8例[J]. 中医药学报, 1998,26(4):33
[19] Han JJ . One case of acute kidney function failure death caused by poison effect of Semen Strychni[J]. Zhong Ri You Hao Yi Yuan Xue Bao, 1999,13(1):14
doi: 10.3969/j.issn.1001-0025.1999.01.027
韩进军 . 马钱子中毒致急性肾功能衰竭死亡1例[J]. 中日友好医院学报, 1999,13(1):14
doi: 10.3969/j.issn.1001-0025.1999.01.027
[20] Zhao HW, Weng SA, Zhu YN , et al. Effects of brucine on murine lymphocyte functions[J]. Zhongguo Yao Li Xue Tong Bao, 1999,15(4):354-356
赵红卫, 翁世艾, 朱燕娜 , 等. 马钱子碱对小鼠淋巴细胞功能的影响[J]. 中国药理学通报, 1999,15(4):354-356
[21] Yan YS, Zhou L . Brief analysis of the poisoning reason of Semen Strychni[J]. Luzhou Yi Xue Yuan Xue Bao, 2001,24(4):276
颜永书, 周兰 . 浅析马钱子中毒原因[J]. 泸州医学院学报, 2001,24(4):276
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