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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (7): 711-715.doi: 10.3736/jcim20080710

• Original Experimental Research • Previous Articles     Next Articles

Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study

Xiao-bing Qu1(), Shui-ping Zhao2, Jing Xu3, Li-ni Dong1   

  1. 1. Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China
    2. Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China
    3. Department of Emergency, the First Affiliated Hospital, Hunan Normal University, Changsha, Hunan Province 410006, China
  • Received:2007-11-13 Online:2008-07-20 Published:2008-07-15
  • Contact: QU Xiao-bing

Objective: To investigate the effects of different concentrations of curcumin on secretion of adiponectin (APN) and interleukin-6 (IL-6) in human adipose tissues cultivated in vitro.
Methods: Seven male patients with kidney stones were admitted. Abdominal subcutaneous adipose tissue and perirenal adipose tissue were collected from the operating-patients, and were cultivated with different concentrations of curcumin (10 and 100 μg/ml) in vitro. The contents of APN and IL-6 in the culture medium of adipose tissue cells were measured by enzyme-linked immunosorbent assay (ELISA) after they were cultured for 6 and 24 hours.
Results: Compared with the blank control group, the content of APN in the adipose tissue culture medium was increased by 100 μg/ml curcumin (P<0.05) after 6-hour culture, and the content of IL-6 was significantly decreased by 100 μg/ml curcumin after 6- and 24-hour culture (P<0.05).
Conclusion: 100 μg/ml curcumin can increase APN secretion and decrease IL-6 secretion in human adipose tissues cultivated in vitro.

Key words: adipose tissue, adiponectin, interleukin-6, curcumin

CLC Number: 

  • R285.5

Table 1

Effects of different concentrations of curcumin on APN secretion of adipose tissues ($\bar{x}$±s, ng/kg)"

Group n Subcutaneous adipose tissue Perirenal adipose tissue
6 hours 24 hours 6 hours 24 hours
Blank control 262.33±83.24 379.15±103.79 186.81±55.49 316.59±95.52
10 μg/ml curcumin-treated 295.17±83.79 397.59±118.10 199.91±56.02 325.50±106.40
100 μg/ml curcumin-treated 349.77±54.79* 502.98±100.56* 253.47±45.33* 421.52±103.42

Table 2

Effects of different concentrations of curcumin on IL-6 secretion of adipose tissues ($\bar{x}$±s, ng/kg)"

Group n Subcutaneous adipose tissue Perirenal adipose tissue
6 hours 24 hours 6 hours 24 hours
Blank control 7 3 703.57±663.97 4 402.37±489.28 4 509.02±498.75 5 187.15±365.13
10 μg/ml curcumin-treated 7 3 612.19±667.55 4 137.20±490.13 4 331.99±671.67 4 909.49±701.48
100 μg/ml curcumin-treated 7 2 919.65±652.61* 3 832.05±437.16* 3 445.65±828.33**△ 4 329.95±622.34*
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