Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 897-901.doi: 10.3736/jcim20080904

• Original Clinical Research • Previous Articles     Next Articles

Correlation between syndrome factor combination and cardiac function as well as blood-lipid in coronary heart disease

Jie Wang, Qing-yong He(), Zhan Shi, Yan-wei Xing, Ji Li, Yu-tao Fang, Yan-li Tang   

  1. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Received:2007-12-08 Online:2008-09-20 Published:2008-09-15

Objective: To discuss the distribution laws of traditional Chinese medicine (TCM) syndrome factor and their combination in coronary heart disease (CHD), and to study the correlation between the TCM syndrome factor combination and cardiac function as well as blood-lipid.
Methods: The parameters of the cardiac function of 300 patients with a final diagnosis of CHD by coronary angiography were measured by echocardiography, and the levels of blood lipids in the CHD patients were detected. An analysis of the correlation was done between the TCM syndrome factor combination and cardiac function as well as blood-lipid in CHD.
Results: The TCM syndrome factor combinations of CHD were blood stasis due to qi deficiency, qi and yin deficiency, intermingled phlegm and blood stasis, and yang deficiency and blood stasis. The ejection fraction of CHD patients with yang deficiency and blood stasis was markedly decreased. The levels of triglyceride and low-density lipoprotein cholesterol in CHD patients with intermingled phlegm and blood stasis were markedly increased, and the level of triglyceride in CHD patients with qi and yin deficiency was markedly increased too.
Conclusion: The treatment of CHD should aim directly at the symptoms and causes. It is also proved that some compound traditional Chinese herbal medicines for supplementing qi and activating blood circulation, nourishing yin and resolving phlegm, and activating yang should be used in treatment of CHD. In cases of CHD with low cardiac function, particular emphasis should be laid on activating yang and blood circulation, while in cases of CHD with blood-lipid disturbance, particular emphasis should be laid on resolving phlegm and activating blood circulation, replenishing qi and nourishing yin.

Key words: coronary heart disease, arteriography, symptom complex

CLC Number: 

  • R541.4

Table 1

Distribution regularity of traditional Chinese medicine syndrome factors and their chief combination in coronary heart disease[Cases (%)]"

Syndrome factor and combination Frequency Syndrome factor and combination Frequency
Qi deficiency 226 (75.33%) Heat-stagnation 1(0.33%)
Blood stasis 175 (58.33%) Water-stagnation 0 (0.00%)
Yin deficiency 136 (45.33%) Syndrome of wind 0 (0.00%)
Turbid phlegm 125 (41.67%) Qi deficiency plus blood stasis 130(43.33%)
Yang deficiency 107 (35.67%) Qi deficiency plus yin deficiency 110 (36.67%)
Qi stagnation 4 (1.33%) Intermingled phlegm plus blood stasis 81 (27.00%)
Cold coagulation 3 (1.00%) Yang deficiency plus blood stasis 63 (21.00%)
Dampness pathogen 1 (0.33%)

Table 2

Parameters of cardiac function tested by echocardiography in coronary heart disease of different syndrome factor combinations (x±s, mm)"

Syndrome factor combination n IVS LVEDD LVESD PR
Blood stasis due to qi deficiency 130 10.75±3.32 47.51±8.85 33.65±8.01 7.74±3.69
Qi and yin deficiency 110 10.72±3.17 47.98±8.09 33.64±8.14 7.47±2.05
Intermingled phlegm and blood stasis 81 10.30±3.08 48.90±7.73 34.70±8.58 7.11±2.38
Yang deficiency and blood stasis 63 10.34±3.73 48.17±8.15 34.50±8.29 6.66±2.60
F value/P value 0.48/0.69 0.47/0.70 0.42/0.74 2.28/0.08

Table 3

NYHA grading and parameters of cardiac function tested by echocardiography in coronary heart disease of different syndrome factor combinations (x±s)"

Syndrome factor combination n OT (mm) LVEF E/A NYHA grade
Blood stasis due to qi deficiency 130 30.08±4.87 57.67±10.90 1.34±0.81 1.91±0.87
Qi and yin deficiency 110 29.93±4.53 57.78±11.32 1.33±0.77 2.38±1.09
Intermingled phlegm and blood stasis 81 30.36±4.55 55.70±10.90 1.20±0.60 2.31±1.03
Yang deficiency and blood stasis 63 28.31±4.85 52.46±9.78** 1.49±0.98 2.63±0.74
F value/P value 2.62/0.051 4.07/0.001 1.66/0.17 1.43/0.24

Table 4

Blood-lipid levels in coronary heart disease of different syndrome factor combinations (x±s, mmol/L)"

Syndrome factor combination n TC TG HDL-C LDL-C
Blood stasis due to qi deficiency 130 1 690.2±360.7 1 430.5±790.7 340.3±70.8 1 120.6±340.3
Qi and yin deficiency 110 1 740.7±390.0 1 670.2±900.9* 330.4±70.4 1 170.0±350.2
Intermingled phlegm and blood stasis 81 1 720.6±350.9 1 810.5±1 120.3* 330.3±60.2 1 260.1±340.6*
Yang deficiency and blood stasis 63 1 740.2±310.1 1 450.1±990.6 340.4±70.8 1 110.3±350.6
F value/P value 0.54/0.66 3.48/0.02 0.57/0.63 3.17/0.02
[1] Chen HZ. Internal medicine(3rd ed)[M]. Beijing: People's Medical Publishing House, 1995,( 3rd ed):263-264
陈灏珠.内科学( 第3版)[M]. 北京: 人民卫生出版社, 1995,( 第3版):263-264
[2] Braunwald E, Antman EM, Beasley JW , et al. ACC/AHA 2002 guideline update for management of patients with unstable angina and non-ST-segment elevation myocardial infarction–summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidlines( Committee on the Management of Patients With Unstable Angina )[J]. J Am Coll Cardiol, 2002,40(7):1366-1374
doi: 10.1016/S0735-1097(02)02336-7
[3] Gibbons RJ, Abrams J, Chatterjee K , et al.ACC/AHA guideline update for the management of patients with chronic stable angina–summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines( Committee on the Management of Patients With Chronic Stable Angina) [J].Circulation, 2003, 107: 149-158
doi: 10.1161/01.CIR.0000047041.66447.29
[4] Bei ZP. Diagnostic criteria for diseases of internal medicine[M]. Beijing: Science Press,2001: 1558
贝政平 . 内科疾病诊断标准[M]. 北京: 科学出版社,2001: 1558
[5] Shen ZY . Reference criteria of differentiation of deficiency syndromes in traditional Chinese medicine[J]. Zhong Xi Yi Jie He Za Zhi, 1989,9(2):11
沈自尹 . 中医虚证辨证参考标准[J]. 中西医结合杂志, 1989,9(2):11
[6] Chinese Association of Integrative Medicine, Professi-onal Committee of Blood Circulation.Diagnostic criteria of blood-stasis syndrome[J].Zhong Xi Yi Jie He Za Zhi, 1987, 7(3):Cover 2
中国中西医结合研究会活血化瘀研究专业委员会 .血瘀证诊断标准[J].中西医结合杂志, 1987, 7(3):封2
[7] State Administration of Traditional Chinese Medicine. Vocation criteria of traditional Chinese medicine of People's Republic of China: diagnostic and therapeutic effect evaluation criteria of diseases and syndromes in traditional Chinese medicine[M]. Naijing: Nanjing Univer-sity Press,1994: 18
国家中医药管理局. 中华人民共和国中医药行业标准·中医病证诊断疗效标准[M]. 南京: 南京大学出版社,1994: 18
[8] Zhong JB, Dong SY, Wang J , et al. Statistical analysis of literatures on syndrome elements in 2 689 cases of angina due to coronary heart disease[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2006,13(5):100-101
doi: 10.3969/j.issn.1005-5304.2006.05.064
衷敬柏, 董绍英, 王阶 , 等. 2 689例冠心病心绞痛证候要素的文献统计分析[J]. 中国中医药信息杂志, 2006,13(5):100-101
doi: 10.3969/j.issn.1005-5304.2006.05.064
[9] Li YH, Xiao HS . Study of relationship between cardiac function, hemorheology and syndrome differentiation-type of traditional Chinese medicine in patients with coronary heart disease[J]. Liaoning Zhong Yi Za Zhi, 2004,31(12):998-999
doi: 10.3969/j.issn.1000-1719.2004.12.016
李越华, 肖沪生 . 冠心病中医辨证分型与心功能及血液流变学之间关系的研究[J]. 辽宁中医杂志, 2004,31(12):998-999
doi: 10.3969/j.issn.1000-1719.2004.12.016
[10] Wang J, Yan C, Wu LL , et al. Imaginary of intangible phlegm essence[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 1999,21(10):44-46
王剑, 严灿, 吴丽丽 , 等. “无形之痰”实质假想[J]. 中国中医基础医学杂志, 1999,21(10):44-46
[1] Lu Liu, Ying Gao. Study on the correlation between traditional Chinese medicine syndrome and short-term prognosis of ischemic stroke using logistic regression model and repeated-measures analysis of variance. Journal of Chinese Integrative Medicine, 2012, 10(9): 983-990.
[2] Ying-fei Bi , Jing-yuan Mao , Xian-liang Wang , Ya-zhu Hou , Yi-zhu Lu , Shan Bin Soh , Bo-li Zhang. Clinical epidemiology survey of the traditional Chinese medicine etiology and syndrome differentiation of coronary artery disease: Study protocol of a multicenter trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 619-627.
[3] Yu Zhao, Jing-hua Peng , Xue-mei Li , Qi-lin Fu, Tuan Cui , Qi Li, Ya-jun Tang , Qin Feng , Hua Zhang , Hua Zhou , Yi-yang Hu. Diagnostic value of clinical indices in syndrome differentiation of chronic hepatitis B: an exploration based on receiver operating characteristic curves and stepwise discriminant analysis. Journal of Chinese Integrative Medicine, 2012, 10(12): 1382-1387.
[4] Dong-tao Li, Jian Wang , Hong-yang Jiang , Feng-lei Shi , Fu-yu Li , Ji-hong Liu , Yong-mei Cheng , Nan Yan , Ai-hua Hu, Mei-zeng Zhang , Jie Li, Ling-bo Wei , Rong-qin Jiang. Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1254-1262.
[5] Gui-xiang Chu, Qing-guang Chen, Jia-tuo Xu , Bo Yu , Min Zhang , Long-tao Cui , Hong-jin Wu , Zhao-fu Fei. Analysis on pulse diagram characteristics of subjects with subhealth state. Journal of Chinese Integrative Medicine, 2012, 10(10): 1099-1105.
[6] Xing-jiang Xiong, Hai-xia Li . Experience on clinical application of Chinese herbal medicine Yi Guan Jian decoction. Journal of Chinese Integrative Medicine, 2011, 9(8): 920-923.
[7] Ji Sun, Sheng-liang Zhu, Shu-ying Ma, Xiao-su Wang, Jing Kong. Clinical characteristics of patients with reflux esophagitis exhibiting gallbladder heat attacking the stomach or stagnant heat of the liver and stomach syndrome. Journal of Chinese Integrative Medicine, 2011, 9(7): 732-736.
[8] Tian-fang Wang, Xiao-lin Xue, Ya-jing Zhang, Ping Han, Zhen Li, Wen-ping Wang, Jian-min Xing, Qing-bo Wang, Yu Tang, Li Li, Jia-jia Wang, Guan-ru Li, Shao-liang Ji, Liu-xin Wu, Yan Zhao, Xiu-yan Wu, Run-shuan Zhao. Effects of Xiaopi Yishen herbal extract granules in treatment of fatigue-predominant subhealth due to liver-qi stagnation and spleen-qi deficiency: A prospective, randomized, placebo-controlled and double-blind clinical trial. Journal of Chinese Integrative Medicine, 2011, 9(5): 515-524.
[9] Mei-jun Lü, Hui-yong Zhang, Zhe Zhang, Guan-lin Yang. Measurement of health-related quality of life in coronary heart disease: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1277-1285.
[10] Jian-peng Du, Da-zhuo Shi , Tian-chang Li, Hao Xu, Hao Chen. Correlation between blood stasis syndrome and pathological characteristics of coronary artery in patients with coronary heart disease. Journal of Chinese Integrative Medicine, 2010, 8(9): 848-852.
[11] Dong-taoLi , Jie Li, Jian Wang, Fu-yu Li, Jing-xiu Zhu, Mei-zeng Zhang, Jun-yan Li, Yan-lai Xu, Ling-bo Wei , Wen-yan Ji, Rong-qin Jiang, Xue-fa Liu. Quantitative evaluation of the degrees of qualitative syndromes commonly encountered in patients with coronary heart disease. Journal of Chinese Integrative Medicine, 2010, 8(8): 750-756.
[12] Kai Qu, Tian-fang Wang, Yan Zhao, Xiao-lin Xue, Xiu-yan Wu, Hua-liang Deng, Lu Yang, Li-liYu , Hong Yue, Qing-guo Wang. Common syndrome factors of traditional Chinese medicine in chronic renal failure based on the questionnaire investigation among experts. Journal of Chinese Integrative Medicine, 2010, 8(12): 1147-1152.
[13] Chan Chen, Yong-mei Meng , Peng Zhang, Juan Wang, Hui-hui Zhao, Shu-zhen Guo , Wei Wang. Diagnosis and treatment rule of traditional Chinese medicine for syndrome factors of chronic congestive heart failure: a study based on Shannon entropy method. Journal of Chinese Integrative Medicine, 2010, 8(11): 1080-1084.
[14] Mei Xue , Ke-ji Chen, Hui-jun Yin. Relationship between polymorphism of platelet membrane glycoprotein Ⅲa and coronary heart disease with blood-stasis syndrome in Chinese Han population. Journal of Chinese Integrative Medicine, 2009, 7(4): 325-329.
[15] Wen-juan Wang , Zhi-kui Wu , Xin-hua Zhang , Wen-jun Liu , Yong-mei Liu , Su-ping Fang , Rong-xin Wang , Chong Zhang , Ping-ping Li , Rui-gui Luo . A family survey of syndromes of traditional Chinese medicine in patients with β-thalassemia. Journal of Chinese Integrative Medicine, 2009, 7(2): 116-120.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[4] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[5] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[6] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[7] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[8] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[9] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[10] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017