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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1255-1258.doi: 10.3736/jcim20081209

• Original Experimental Research • Previous Articles     Next Articles

Rhizoma Panacis majori reduces toxicity of chemotherapy in S180-bearing mice

Tao Chen1(), Zhang-bin Gong2, Ya-ling Fu1   

  1. 1. Department of Traditional Chinese Medicine,Medical College of Three Gorges University, Yichang, Hubei Province 443002, China
    2. Department of of Biochemistry, Basic Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2008-04-09 Online:2008-12-20 Published:2008-12-15

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Objective: 

To observe the attenuating effect of Rhizoma Panacis majoris (RPM) on toxicity of 5-fluorouracil (5-FU) chemotherapy in S180-bearing mice.


Methods:

S180 cells were subcutaneously injected to the right armpit of the mice to establish the S180-bearing model, and thirty mice were randomly divided into untreated group, 5-FU group and 5-FU combined with RPM group (5-FU plus RPM group). The general condition of S180-bearing mice was observed. The white blood cells, red blood cells, and reticulocytes in the peripheral blood were counted, and the ratio of reticulocytes was measured too. The life-span of the S180-bearing mice was recorded.


Results: 

The white blood cell count and the ratio of reticulocytes in 5-FU plus RPM group were higher than those in 5-FU group (P<0.01). The average lifespan of 5-FU plus RPM group was 32.5 days and that of the 5-FU group was 23.5 days; there was a significant difference in the lifespan between the two groups (P<0.01).


Conclusion: 

RPM can reduce the toxic effect of 5-FU and prolong the lifespan of S180-bearing mice.

Key words: Codonopsis convolvulacea, chemotherapy, sarcoma 180, mice

CLC Number: 

  • R730.52

Table 1

WBC counts in S180-bearing mice before and after chemotherapy (x±s, ×109/L)"

Group n Count of WBC
Before treatment After 3-day treatment After 5-day treatment
Untreated 10 9.78±1.34 10.41±0.99▲▲ 9.85±1.13▲▲
5-FU 10 9.50±1.49 7.47±1.04**△△ 3.93±0.55**△△
5-FU+RPM 10 9.94±0.89 8.60±0.93*△△▲ 6.07±0.83**△△▲▲

Table 2

Ratio of Ret in S180-bearing mice before and after chemotherapy (x±s, %)"

Group n Ratio of Ret
Before treatment After 3-day treatment After 5-day treatment
Untreated 10 5.83±1.58 4.98±1.56*▲▲ 5.29±1.45▲▲
5-FU 10 5.72±1.84 2.31±1.23**△△ 0.21±0.15**△△
5-FU+RPM 10 5.67±2.00 3.37±1.17**△▲▲ 2.45±1.14**△△▲▲
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