基于Apriori算法的中药气-味-效三维数据关联规则挖掘研究

doi:10.3736/jcim20110715

Abstract

The theory of four properties (Qi) and five tastes (Wei) is the core of the property theory of Chinese materia medica. It is known that Qi and Wei are associated with the pharmacological effects (Xiao) of herbs. This study took records of all 365 Chinese herbs in Shennong’s Classic of Materia Medica (Shennong Ben Cao Jing) as the data resource and established a three-dimensional data cube, in the purpose of finding out and analyzing the frequent patterns and valued association rules of Qi, Wei and Xiao based on Apriori algorithm. The results of this study may give rise to innovative ideas and methods in research of traditional Chinese materia medica.

Key words: properties and flavours, 4 natures and 5 flavours, Bencaojing, mathematics, Apriori algorithms, Chinese medicine property theory

Jin Rui, Lin Qian, Zhang Bing, Liu Xin, Liu Sen-mao, Zhao Qian, Liu Xiu-lan. A study of association rules in three-dimensional property-taste-effect data of Chinese herbal medicines based on Apriori algorithm. Journal of Chinese Integrative Medicine, 2011, 9(7): 794-803.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20110715

http://www.jcimjournal.com/EN/Y2011/V9/I7/794

[1]	Gao XM. Chinese materia medica[M]. Beijing: People’s Medical Publishing House, 2000: 46-50
	高学敏 . 中药学[M]. 北京: 人民卫生出版社, 2000: 46-50
[2]	Zhang B, Lin ZJ, Zhai HQ, Huang JM . A research of traditional Chinese medicine property theory based on “three elements” hypojournal[J]. Zhongguo Zhong Yao Za Zhi, 2008,32(2):221-223
	张冰, 林志健, 翟华强, 黄建梅 . 基于“三要素”假说研究中药药性的设想[J]. 中国中药杂志, 2008,32(2):221-223
[3]	Zheng JS. Related historical process of development of Chinese medicine[M]. Guilin: Guangxi Normal University Press, 2007: 35, 79
	郑金生 . 药林外史[M]. 桂林: 广西师范大学出版社, 2007: 35, 79
[4]	Liang MX, Fan Y . Research on four properties of Chinese herb: current status, problems and countermeasures[J]. Zhonghua Zhong Yi Yao Za Zhi, 2008,23(7):565-568
	梁茂新, 范颖 . 中药四性研究的现状、问题和对策[J]. 中华中医药杂志, 2008,23(7):565-568
[5]	Jin R, Lin Q, Liu SM, Zhao Q, Zhang Q, Zhang B . Mathematical analysis of the relationship between yang-deficiency syndrome in traditional Chinese medicine and its objective indicators in clinical literature[J]. J Chin Integr Med, 2010,8(7):678-683
	金锐, 林茜, 刘森茂, 赵茜, 张倩, 张冰 . 基于数学方法的中医“阳虚证”与临床文献中客观指标的关联分析[J]. 中西医结合学报, 2010,8(7):678-683
[6]	Han J, Kamber M. Translated by Fan M, Meng XF.Data mining: concepts and techniques(2nd ed)[M]. Beijing: China Machine Press,2007:101- 109, 146-155
	Han J, Kamber M , 著. 范明, 孟小峰, 译.数据挖掘:概念与技术(第2版)[M]. 北京: 机械工业出版社,2007:101- 109, 146-155
[7]	Gu GG. Anotated by Yang PJ.Shennong’s classic of materia medica[M]. Beijing: Academy Press,2007: Preface, 1-271
	顾观光 , 辑. 杨鹏举, 校注.神农本草经[M]. 北京: 学苑出版社,2007:前言, 1-271
[8]	Zhang L, Gong ZL, Chen Y, Gu SD. Information mining of biological data[M]. Shanghai: Shanghai Scientific and Technical Publishers, 2008: 17, 46-53
	章鲁, 龚著琳, 陈瑛, 顾顺德 . 生物医学数据挖掘[M]. 上海: 上海科学技术出版社, 2008: 17, 46-53
[9]	Li H, Cai ZH . Application of association rules in medical data analysis[J]. Wei Ji Fa Zhan, 2003,13(6):94-97 doi: 10.3969/j.issn.1673-629X.2003.06.033
	李虹, 蔡之华 . 关联规则在医疗数据分析中的应用[J]. 微机发展, 2003,13(6):94-97 doi: 10.3969/j.issn.1673-629X.2003.06.033
[10]	Li XJ . Application of improved Apriori algorithm in data mining of compound-prescriptions of traditional Chinese medicine[J]. Zhongguo Wei Sheng Tong Ji, 2007,24(6):656-658 doi: 10.3969/j.issn.1002-3674.2007.06.036
	李湘君 . 改进的Apriori算法在中药复方数据挖掘中的应用[J]. 中国卫生统计, 2007,24(6):656-658 doi: 10.3969/j.issn.1002-3674.2007.06.036
[11]	Wei J . A study of association rules mining and model design in medical records system[J]. Guangxi Jiao Yu Xue Yuan Xue Bao, 2010,( 1):136-139
	魏建 . 医学病历系统规则挖掘算法研究及模型设计[J]. 广西教育学院学报, 2010,( 1):136-139
[12]	Wang YY, Lu ZL. Traditional Chinese internal medicine[M]. Beijing: People’s Medical Publishing House, 1999: 294-900
	王永炎, 鲁兆麟 . 中医内科学[M]. 北京: 人民卫生出版社, 1999: 294-900
[13]	Tan XH, Lu DM. Traditional Chinese external medicine[M]. Beijing: People’s Medical Publishing House, 1999: 103
	谭新华, 陆德铭 . 中医外科学[M]. 北京: 人民卫生出版社, 1999: 103
[14]	Chao YF. Edited by China Association of Chinese Medicine.One hundred classics of traditional Chinese medicine: Treatise on the pathogenesis and manifestations of all diseases[M]. Beijing: Hua Xia Publishing House, 2008: 41-223
	巢元方 , 辑. 中华中医药学会, 编.中医必读百部名著·诸病源候论[M]. 北京: 华夏出版社, 2008: 41-223
[15]	Liu MR, Tan WX. Obstetrics and gynecology of traditional Chinese medicine[M]. Beijing: People’s Medical Publishing House, 2001: 292-424
	刘敏如, 谭万信 . 中医妇产科学[M]. 北京: 人民卫生出版社, 2001: 292-424
[16]	Jin R, Zhang B, Xue CM, Liu SM, Zhao Q, Li K . A study of the classification of 365 Chinese medicines in Shennong’s Classic of Materia Medica based on a semi-supervised incremental clustering method[J]. J Chin Integr Med, 2011,9(6):665-674 doi: 10.3736/jcim20110614
	金锐, 张冰, 薛春苗, 刘森茂, 赵茜, 李康 . 基于半监督增量聚类法的《神农本草经》365味中药分类研究[J]. 中西医结合学报, 2011,9(6):665-674 doi: 10.3736/jcim20110614
[17]	Yuan Z, Tu Y, Peng ZB, Che JT. Grand dictionary of traditional Chinese medicine(Vol 3)[M]. Beijing: China Medical Science Press, 1999: 237
	袁钟, 图娅, 彭泽邦, 车建途 . 中医辞海(下册 )[M]. 北京: 中国医药科技出版社, 1999: 237
[18]	Li JW, Yu YA, Cai JF. Dictionary of essential terms of traditional Chinese medicine[M]. Tianjin: Tianjin Science and Technology Press, 1996: 1059
	李经纬, 余瀛鳌, 蔡景峰 . 中医名词术语精华辞典[M]. 天津: 天津科学技术出版社, 1996: 1059
[19]	Liu Y. Medical books of Xu Ling-tai[M]. Beijing: China Press of Traditional Chinese Medicine, 1999: 264-266
	刘洋 . 徐灵胎医学全书[M]. 北京: 中国中医药出版社, 1999: 264-266
[20]	Xiong MQ. Treatise on cold damage diseases[M]. Beijing: People’s Medical Publishing House, 2000: 9-24
	熊曼琪 . 伤寒论[M]. 北京: 人民卫生出版社, 2000: 9-24
[21]	Zhu CQ. Tutorials of modern Chinese grammar[M]. Beijing: University of International Business and Economics Press, 2002: 159
	朱成器 . 现代汉语语法教程[M]. 北京: 对外经济贸易大学出版社, 2002: 159
[22]	Chang WZ, Liu SM, Lu F . Analysis and prospects of relationship between Chinese materia medica property and pharmacological activities[J]. Shizhen Guo Yi Guo Yao, 2009,20(3):633-634 doi: 10.3969/j.issn.1008-0805.2009.03.062
	常惟智, 刘树民, 卢芳 . 中药药性与功效关联性的研究分析及展望[J]. 时珍国医国药, 2009,20(3):633-634 doi: 10.3969/j.issn.1008-0805.2009.03.062
[23]	Wang L, Chang CK, Wang BL . Logical perspective view of the Chinese herb property theory[J]. Yi Xue Yu Zhe Xue Ren Wen She Hui Yi Xue Ban, 2009,30(12):56-57
	王磊, 常存库, 王宝伦 . 逻辑学视野下的中药药性理论[J]. 医学与哲学人文社会医学版, 2009,30(12):56-57
[24]	Jiang JC, Megan E, Fang XM . English translation of the term “shu” in traditional Chinese medicine[J]. J Chin Integr Med, 2007,5(6):715-717
	蒋基昌, Megan E, 方显明 .中医“属”字的英译[J]. 中西医结合学报, 2007,5(6):715-717
[25]	Wang Q . Discussion on the traits and developing tendency of traditional Chinese medicine theory[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2005,11(1):4-13
	王琦 . 论中医理论的特质与路向[J]. 中国中医基础医学杂志, 2005,11(1):4-13
[26]	Wang L, Peng JS, Yang YS . Philosophical analysis of the Chinese herb property theory[J]. Yi Xue Yu Zhe Xue Ren Wen She Hui Yi Xue Ban, 2010,31(3):52-53
	王磊, 彭劲松, 杨云松 . 中药药性理论的哲学诠析[J]. 医学与哲学人文社会医学版, 2010,31(3):52-53
[27]	Yang XW. Absorption, distribution, metabolism, excretion, toxicity and activity of the chemical constituents in traditional Chinese medicines(Vol 1)[M]. Beijing: China Medical Science Press, 2006: 56-57
	杨秀伟 . 中药成分的吸收、分布、代谢、排泄、毒性与药效(上册)[M]. 北京: 中国医药科技出版社, 2006: 56-57

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2]	Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3]	Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4]	SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5]	Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6]	Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7]	Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8]	Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9]	Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10]	Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239

名称	类型1	类型2
寒热	“寒热”单独出现：营卫表证	“寒热”前后有定语（如脏腑、骨节、腹中、皮肤）：寒热病
邪气	“邪气”单独出现或为“寒热邪气”：致病因素	“邪气”前后有定语（如心腹、心下）：馀气、气滞

功效	气?效			效?气
功效	寒	平	温	寒	平	温
轻身延年	26.8%	48.4%	34.6%	19.6%	46.6%	21.1%
除热	30.9%	11.7%	6.2%	48.4%	24.2%	8.1%
欬逆上气	6.2%	10.2%	24.7%	14.0%	30.2%	46.5%
金疮	1.0%	3.9%	8.6%	5.3%	26.3%	36.8%

四气	气?效				效?气
四气	>45%	45%~35%	35%~15%	<15%	>45%	45%~35%	35%~15%	<15%
温	0	0	9	84	6	11	50	26
微温	0	3	9	81	0	0	14	79
平	1	0	5	87	18	26	43	6
微寒	0	2	6	85	0	0	16	77
寒	0	0	9	84	14	6	52	21

四气	气?效	效?气
温	—	痿病?温 (66.7%),风头眩痛?温 (64.7%),温中?温 (63.6%),下气?温 (50.0%),和颜色?温 (47.1%),欬逆上气?温 (46.5%)
微温	—	—
平	平?轻身延年 (48.4%)	腰痛?平 (88.9%),肥健?平 (75.0%),安魂魄?平 (71.4%),不饥?平 (59.3%),痉病?平 (58.8%),阴痿不起?平 (56.3%),强志?平 (52.6%),通血脉?平 (50.0%),益子精?平 (50.0%),痂疥?平 (50.0%),和五脏?平 (50.0%),痔?平 (50.0%),解毒?平 (50.0%),补中?平 (48.9%),轻身延年?平 (46.6%),养精神?平 (46.15%),益精气?平 (45.5%),坚筋骨?平 (45.5%)
微寒	—	—
寒	—	消渴?寒 (77.8%),荡涤蓄结饮食?寒 (77.8%),黄疸?寒 (63.6%),杀虫虱毒?寒 (62.5%),淋病?寒 (50.0%),身面浮肿?寒 (50.0%),泄泻?寒 (50.0%),除热?寒 (48.4%),烦满?寒 (46.7%),消水?寒 (46.7%),利水道?寒 (45.9%),目赤痛?寒 (45.5%), 折跌绝筋?寒 (45.5%),臌胀?寒 (45.5%)

五味	味?效				效?味
五味	>45%	45%~35%	35%~15%	<15%	>45%	45%~35%	35%~15%	<15%
酸	1	0	8	84	0	1	4	88
苦	0	0	7	86	17	25	38	13
甘	2	0	5	86	13	7	34	39
辛	0	0	9	84	16	11	46	20
咸	0	0	6	87	0	1	20	72

A study of association rules in three-dimensional property-taste-effect data of Chinese herbal medicines based on Apriori algorithm

RichHTML

PDF (PC)

Like

Abstract

Cite this article

Share this article

TrendMD

Figures/Tables 9

References 27

Related Articles 7

Metrics

Comments

Recommended 10

	味?效	效?味
酸	酸?轻身延年 (46.7%)	—
苦	—	瘿瘤瘰疬?苦 (83.3%),黄疸?苦 (81.8%),荡涤蓄结饮食?苦 (77.8%),臌胀?苦 (72.7%),身面浮肿?苦 (64.3%),除热?苦 (61.3%),消渴?苦 (55.6%),痔?苦 (55.6%),消水?苦 (53.3%),痈疽疮疡?苦 (50.8%),止痛?苦 (50.0%),疥瘙?苦 (50.0%),通血脉?苦 (50.0%),痿病?苦 (50.0%),痉病?苦 (47.1%),目赤痛?苦 (45.5%),结气?苦 (45.2%)
甘	甘?轻身延年 (76.3%),甘?益精气 (48.7%)	不饥?甘 (77.8%),安魂魄?甘 (71.4%),长肌肉?甘 (66.7%),虚劳羸瘦?甘 (60.0%),养精神?甘 (53.8%),崩中漏下?甘 (53.3%),聪耳?甘 (52.9%),肥健?甘 (50.0%),除百病?甘 (50.0%),补中?甘 (48.9%),益精气?甘 (48.1%),和颜色?甘 (47.1%),补不足?甘 (46.2%)
辛	—	胸满?辛 (66.7%),辟恶气?辛 (66.7%),身痒?辛 (66.7%),温中?辛 (63.6%),通神明?辛 (62.5%),下气?辛 (58.3%),疝瘕?辛 (55.6%),精魅邪鬼?辛 (54.2%),恶肉死肌?辛 (53.8%),风头眩痛?辛 (52.9%),疟疾?辛 (52.4%),欬逆上气?辛 (51.2%),杀虫虱毒?辛 (50.0%),痂疥?辛 (50.0%),中风?辛 (47.6%),杀蛊毒?辛 (46.2%)
咸	—	—

四气	（气∧味）?效	效?（气∧味）
温	甘温?轻身延年 (57.1%),甘温?益精气 (50.0%)	温中?辛温 (54.5%),风头眩痛?辛温 (41.2%)
微温	甘微温?轻身延年 (60.0%),甘微温?益精气 (60.0%),辛微温?轻身延年 (44.4%),咸微温?癥瘕积聚 (66.7%)	—
平	酸平?轻身延年(57.1%),酸平?益精气 (42.9%),酸平?痹病 (42.9%),甘平?轻身延年 (84.2%),甘平?益精气 (50.0%)	不饥?甘平 (51.9%),安魂魄?甘平 (42.9%)
微寒	苦微寒?除热 (52.9%),甘微寒?轻身延年 (100.0%)	—
寒	甘寒?轻身延年 (73.3%),甘寒?寒热（营卫表证） (40.0%),甘寒?益精气 (40.0%),辛寒?除热 (47.4%),辛寒?痈疽疮疡 (42.1%)	荡涤蓄积饮食?苦寒 (66.7%),消渴?苦寒 (55.6%),黄疸?苦寒 (54.5%),臌胀?苦寒 (45.5%),身面浮肿?苦寒 (42.9%)

[1]	Liang Ding, Xin-you Zhang, Di-yao Wu, Meng-ling Liu. Application of an extreme learning machine network with particle swarm optimization in syndrome classification of primary liver cancer. Journal of Integrative Medicine, 2021, 19(5): 395-407.
[2]	Rui Jin, Bing Zhang , Xiao-qing Liu , Chun-miao Xue , Qian Zhang, Lian-zhen Li, Qian Zhao, Kang Li . A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property. Journal of Chinese Integrative Medicine, 2012, 10(10): 1106-1119.
[3]	Rui Jin, Bing Zhang, Chun-miao Xue, Sen-mao Liu, Qian Zhao, Kang Li. Classification of 365 Chinese medicines in Shennong's Materia Medica Classic based on a semi-supervised incremental clustering method. Journal of Chinese Integrative Medicine, 2011, 9(6): 665-674.
[4]	Da-wei Pan, Li-guo Chen. Mathematical modeling of sign-and-symptom-oriented diagnostic procedure in traditional Chinese medicine based on the analytic hierarchy process: Indications of Guizhi Decoction and its varieties in the Shanghanlun. Journal of Chinese Integrative Medicine, 2011, 9(4): 354-360.
[5]	Le Kuai, Ru-feng Jin, Ming Gao, Hua-yuan Yang. Fuzzy cluster analysis of therapeutic effects of electro-acupuncture at different parameters. Journal of Chinese Integrative Medicine, 2009, 7(5): 478-481.
[6]	Lei Wang, Yue Su, Qin Zhang, Ping Liu, Shi-bing Su. Classification and modeling of traditional Chinese medicine syndromes in patients with posthepatitic cirrhosis by partial least-squares. Journal of Chinese Integrative Medicine, 2008, 6(11): 1122-1128.
[7]	Long Liu, Ling Xu, Da-zhi Sun, Pin-kang Wei. Establishment of a fuzzy mathematical model for syndrome differentiation of gastric cancer. Journal of Chinese Integrative Medicine, 2008, 6(11): 1117-1121.