基于半监督增量聚类法的《神农本草经》365味中药分类研究

doi:10.3736/jcim20110614

Abstract

Evidence of the pharmacological activity of traditional Chinese medicine (TCM) provides the basis for clinical prescription. Study of the classification of Chinese medicines according to these activities is key to understanding the general active tendencies of medicinal prescriptions, exploring their material basis, investigating their properties and searching for their alternatives. Taking the herbal classic Shennong's Materia Medica Classic (Shennong Bencao Jing) for the data source, this paper studied the classification of Chinese medicines based on semi-supervised incremental clustering algorithm using "micro-cluster" concept in order to investigate the complex similarity among Chinese medicines. The results showed that 253 Chinese medicines were reasonably classified into 14 types, such as invigoration, clearing heat, diuresis, dredging blockages in the channels, treating gynecological conditions and treating strange diseases caused by ghosts. The results also showed that the other 112 Chinese medicines were classified into 112 individual types and the same high similarity to different known types was the main reason for this. The semi-supervised incremental clustering algorithm employed in the study had a high quality and a good development for clustering which is suitable for classification of Chinese medicines. This study illustrated the diversity of Chinese medicines and their complex similarities, thus aiming to provide innovative ideas and methods for related research.

Key words: drugs,Chinese herbal, semi-supervised incremental clustering, classification, cluster analysis, Bencaojing, data mining

Rui Jin, Bing Zhang, Chun-miao Xue, Sen-mao Liu, Qian Zhao, Kang Li. Classification of 365 Chinese medicines in Shennong's Materia Medica Classic based on a semi-supervised incremental clustering method. Journal of Chinese Integrative Medicine, 2011, 9(6): 665-674.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20110614

http://www.jcimjournal.com/EN/Y2011/V9/I6/665

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Figures/Tables 1

统一名称	原名称	参考文献
轻身延年不老	轻身、延年、不老、神仙	《本经》P1,《药林外史》^[4]P81
荡涤胃内积聚	荡胃中积聚、涤积聚饮食、逐六腑积聚	《本经》P18、144
虚劳羸瘦	虚劳、劳极、羸瘦、五劳七伤	《中医内科学》P855,《本经》P73、109
痈疽疮疡	痈、痈肿、疽、疡、伤热火烂、赤熛、浸淫疮	《中医外科学》P103,《本经》P178,《诸病源候论》P206、223
风头眩痛	风头脑动、头眩痛、风入脑户	《中医内科学》P294,《本经》P102
恶肉死肌	恶肉、死肌、息肉	《本经》P13、141
身面浮肿	肢体（满）浮肿、风水	《本经》P155、174
癥瘕积聚	癥瘕积聚、留固结癖、坚瘕、癥坚（痞）、血瘕（积）	《中医内科学》P867,《本经》P66
瘿瘤瘰疬	瘿瘤、瘰疬、颈下核、鼠瘘	《本经》P9、170
欬逆上气	欬（咳）逆上气、（胸胁）逆气	《本经》P15、96
带下赤白	漏下赤白、白沃、带下赤白	《中医妇产科学》^[8]P424,《本经》P16
崩中漏下	下血、漏下、崩中	《中医妇产科学》P292,《本经》P183
养精神	（安）养（精）神、安心	《本经》P11、98
安魂魄	（定、强）安魂魄	《本经》P11、192
止惊悸	止（定）惊悸（气）	《本经》P31、86
和五脏	安（定、和）五脏	《本经》P53、101
辟恶气	辟（邪）恶气（不祥）	《本经》P68、210
填髓脑	（强、填）补骨髓（脑）	《本经》P36、109
增智慧	益（增）智（慧）	《本经》P53、63
益精气	益气（力）、益精气、益脾、肺、肾气,倍力	《本经》P52、64
益子精	多（有、增、益）子（阴）精	《本经》P15、137
和颜色	面生光、润泽、和颜色、媚好	《本经》P70、81
坚筋骨	坚骨齿（强骨节）、坚（强）筋骨	《本经》P17、57
利关节	通（利）百（关）节	《本经》P15、83
通血脉	通（保）血脉、逐血、通血气	《本经》P21、262
痫病	癫、痓	《中医内科学》P345,《本经》P46
痉病	痉、瘈疭、项背强急	《中医内科学》P567,《本经》P175
痹病	寒痹、风痹、湿痹、周痹、痹气,四肢拘挛、机关缓急、屈伸不利,胫重酸痛、骨节痛、膝痛	《中医内科学》P900,《诸病源候论》P41,《本经》P74、95
痿病	痿躄、四肢偏痿、四肢重弱	《中医内科学》P370
淋病	淋、气癃闭,溺不下、小便余沥,膀胱热	《中医内科学》P660,《本经》P47
虫病	杀三虫、去长虫、去白虫	《本经》P135、181
补中	补中、补五脏、补内	《本经》P73、94
除热	除热、主身（大或暴）热	《本经》P37、141
卒中	偏枯、中风 [依具体语境]	《中医内科学》P308,《本经》P196
泄泻	泄澼、肠（泄）澼、泄痢	《中医内科学》P495,《本经》P8
痢疾	下痢脓血、下痢赤白	《中医内科学》P434
疟疾	温疟、痎疟、疟	《中医内科学》P924,《本经》P116、124
臌胀	大腹水肿、腹中水气、大水	《中医内科学》P605,《本经》P8、271
便秘	胃胀闭、厌谷胃闭（痹）	《中医内科学》P510,《本经》P18、114
绝子	绝子、无子、不孕,令人有子	《本经》P135
阴蚀	阴蚀、阴疮、阴中肿痛	《本经》P16、137
瘀血	瘀（留、止）血、恶血	《本经》P71、74
恶疮	恶疮（不瘳）、久败疮	《本经》P72、138
消水	（除、逐、下）消水（气）	《本经》P41、143
消食	消（化）食（利水谷）	《本经》P96、239
解毒	解（诸）毒、鉤吻、鸩羽、蛇螫、蜂、猘狗、菜、肉毒	《本经》P120、211
烦满	烦热、烦满、大烦	《本经》P84、133
惊	惊痫,[凡“惊”字]	《诸病源候论》P43,《本经》P9、170

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Classification of 365 Chinese medicines in Shennong's Materia Medica Classic based on a semi-supervised incremental clustering method

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