Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (7): 601-606.doi: 10.3736/jcim20090701

• Review •     Next Articles

Study of combination methods for formula composition of Chinese herbal medicines and their components

 Xin-jun Liu, Shi-bing Su   

  1. Research Center for Traditional Chinese Medicine Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2009-04-19 Accepted:2009-05-14 Online:2009-07-20 Published:2009-07-15
  • Contact: Shi-bing Su E-mail:shibingsu@yahoo.com

Chinese prescription is composed of Chinese herbal medicines according to "seven compatible" and "sovereign, minister, assistant and courier" principles. There are many methods in the research on combination and composition of Chinese herbal medicines. These methods are classified into traditional model and modern model. For the time being, compatibility study of traditional Chinese herbal medicines has developed from traditional model to modern model. The traditional model mainly studies the effects and mechanisms of the whole and split formulae in medical crude drug level, while the modern model mainly studies the effects and mechanisms of Chinese herbal medicine compositions in components combination level. Moreover, quantitative analysis becomes probable by modern model method. Now, setting up of new components combination model and optimal composition methods will not only develop the combination and the composition of Chinese herbal medicines from medicinal crude drug level to components composition level, but also get new formulae which have clear components and effects, and action targets and mechanisms. It will effectively promote the development of Chinese medicine formula.

Key words: Chinese herbal drugs, Compatibility, Principle

[1] Zhang YZ, Li YF, Yu NJ, Yuan L, Zhao YM, Xiao WB, Luo ZP . Antidepressant-like effects of the ethanolic extract of Xiaobuxin-Tang, a traditional Chinese herbal prescription in animal models of depression[J]. Chin Med J (Engl), 2007,120(20):1792-1796
[2] Yuan L, Wu MY, Sun RY . Effects of compound Liuyi decoction and its components on the function of immune cells in Xuexu mice[J]. Zhongguo Lin Chuang Yao Li Yu Zhi Liao Xue, 2002,7(1):35-36
doi: 10.3969/j.issn.1009-2501.2002.01.011
袁栎, 吴敏毓, 孙瑞元 . 复方六一汤及其拆方组分对血虚小鼠细胞免疫功能的影响[J]. 中国临床药理与治疗学, 2002,7(1):35-36
doi: 10.3969/j.issn.1009-2501.2002.01.011
[3] Yu LZ, Wu JY, Luo JB, Huang XG, Lin H, Xing YL . Experimental study of anti-diarrhea effects of Gegen Qinlian Decoction and its compounds[J]. Zhong Cheng Yao, 2005,27(3):300-304
余林中, 伍杰勇, 罗佳波, 黄旭光, 林慧, 邢雅玲 . 葛根芩连汤配伍抗腹泻药效实验研究[J]. 中成药, 2005,27(3):300-304
[4] Zhao XY, Li J . Experimental study on effect of Taohe Chengqi Decoction and divided prescriptions on TNF and IL-6 with model rats of UUO[J]. Liaoning Zhong Yi Za Zhi, 2007,34(5):678-680
doi: 10.3969/j.issn.1000-1719.2007.05.091
赵雪莹, 李冀 . 桃核承气汤及其拆方对单侧输尿管梗阻大鼠TNF、IL-6影响的实验研究[J]. 辽宁中医杂志, 2007,34(5):678-680
doi: 10.3969/j.issn.1000-1719.2007.05.091
[5] Zhao YL, Qu YZ . The effects of Buyanghuanwu Decoction and the separate components on the activity of MPO and apoptosis of the neuronal cell after cerebral ischemia[J]. Zhongguo Zhong Yi Ji Zheng, 2007,16(3):317-319
赵燕玲, 曲友直 . 补阳还五汤及拆方对脑缺血后髓过氧化物酶活性及神经细胞凋亡的影响[J]. 中国中医急症, 2007,16(3):317-319
[6] Wang XJ, Wang XQ, Li Y, Zhou Z . Effect of BanXia XieXin Tang on gastric emptying motility in mice[J]. Zhonghua Zhong Yi Yao Xue Kan, 2008,26(5):1072-1073
王秀杰, 王学清, 李岩, 周卓 . 半夏泻心汤及拆方对小鼠胃排空影响的实验研究[J]. 中华中医药学刊, 2008,26(5):1072-1073
[7] Li Y, Wang XQ, Zhang WW, Wang JY . Effect of Zhuxiang powder on gastric and intestinal motility in mice[J]. Shi Jie Hua Ren Xiao Hua Za Zhi, 2003,11(5):575-577
李岩, 王学清, 张卫卫, 王江玥 . 术香冲剂对小鼠胃肠动力的影响[J]. 世界华人消化杂志, 2003,11(5):575-577
[8] Lin RH, Fan H, Tian Y, Chen B, Fu YQ, Wang H, Wang Y, Sun KF . Study on proportioning of modified Ephedra Asarum herb aconite decoction formula and dose[J]. Zhonghua Zhong Yi Yao Xue Kan, 2008,26(1):123-124
林瑞红, 樊晖, 田原, 陈缤, 付勇强, 王珲, 王英, 孙科峰 . 加味麻黄附子细辛汤的组方合理性与药物配比剂量研究[J]. 中华中医药学刊, 2008,26(1):123-124
[9] Wang HF, Gao XM, Zhang XZ, Hu SM . The project of applying DED to the medicines screening and grading-up in TCM compound prescriptions[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 1999,2(22):28-31
doi: 10.3321/j.issn:1006-2157.1999.03.012
王洪飞, 高学敏, 张学中, 胡素敏 . DED技术用于中药复方的全方药物筛选及优化的方案设计[J]. 北京中医药大学学报, 1999,2(22):28-31
doi: 10.3321/j.issn:1006-2157.1999.03.012
[10] Li J, Feng WJ . Experimental study into the effect of raw hawthorn fruit, Alisma and zedoary in treating fatty liver and the interaction for the three herbs[J]. Shanxi Zhong Yi, 2006,22(3):57-58
李晶, 冯五金 . 生山楂、泽泻、莪术对大鼠脂肪肝的影响及其交互作用的实验研究[J]. 山西中医, 2006,22(3):57-58
[11] Tang CH, Cai SX . Application of the combined use of uniform experimental design and orthogonal experimental design in biomedical engineering[J]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2006,23(6):1228-1231
唐春红, 蔡绍皙 . 一种在生物医学工程科研中有实用价值的实验设计方法[J]. 生物医学工程学杂志, 2006,23(6):1228-1231
[12] Zhang HZ, Ma J, Zhang HY, Liang MX, Kang TG . Technical lines and methodologies for treating chronic cholecystitis using optimized TCM prescription[J]. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua, 2007,9(5):25-29
doi: 10.11842/wst.2007.5.[sequence]
张会宗, 马杰, 张慧颖, 梁茂新, 康廷国 . 治疗慢性胆囊炎中药小复方优化的思路与方法[J]. 世界科学技术中医药现代化, 2007,9(5):25-29
doi: 10.11842/wst.2007.5.[sequence]
[13] Wang J, Guo LL, Yang G, Wang YY . Methodology and prospects of study on theory of compatibility of prescriptions in traditional Chinese medicine[J]. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua, 2006,8(1):1-5
王阶, 郭丽丽, 杨戈, 王永炎 . 方剂配伍理论研究方法及研究前景[J]. 世界科学技术中医药现代化, 2006,8(1):1-5
[14] Chen T, Li D, Fu YL, Hu W . Screening of QHF formula for effective ingredients from Chinese herbs and its anti-hepatic cell cancer effect in combination with chemotherapy[J]. Chin Med J (Engl), 2008,121(4):363-368
[15] Shang HC, Zhang BL, Wang YY, Gao XM, Zhao YJ . A method for proportion screening of TCM small prescriptions[J]. Zhongguo Shi Yan Fang Ji Xue Za Zhi, 2003,9(3):1-3
doi: 10.3969/j.issn.1005-9903.2003.03.001
商洪才, 张伯礼, 王永炎, 高秀梅, 赵宜军 . 一种适用于中药小复方配比优选设计方法的建立[J]. 中国实验方剂学杂志, 2003,9(3):1-3
doi: 10.3969/j.issn.1005-9903.2003.03.001
[16] Shang HC, Zhang BL, Gao XM, Wang Y, Kang LY, Li YH, Du R, Jiang HT . Comparative research on pharmacodynamics of different matching of Danshen and Sanqi—effect on myocardial biochemical indices of dog with experimental acute myocardial ischemia(AMI)[J]. Tianjin Zhong Yi, 2002,19(2):43-45
商洪才, 张伯礼, 高秀梅, 王怡, 康立源, 李玉红, 杜嵘, 江海涛 . 丹参/三七不同配比药效学比较研究——对急性实验性心肌缺血犬心肌生化标志物的影响[J]. 天津中医, 2002,19(2):43-45
[17] Wang YP, Li XY, Song CQ, Chen CX, Hu ZB . Effect of different fractions from Danggui Buxue Tang on immunological function in normal and blood-deficiency mouse[J]. Zhong Cao Yao, 2002,33(2):135-138
王燕平, 李晓玉, 宋纯清, 陈长勋, 胡之璧 . 当归补血汤中不同组分对正常及血虚小鼠免疫功能的影响[J]. 中草药, 2002,33(2):135-138
[18] Wu Q , Dong C .The anti-aging action of Liuweidihuang Decoction and its mechanism[J].Zhong Yao Yao Li Yu Lin Chuang,2003, 19(3):6-7, cover 3
doi: 10.3969/j.issn.1001-859X.2003.03.004
伍倩, 董淳 .六味地黄汤及其补、泻组分的抗衰老作用及机制[J].中药药理与临床, 2003, 19(3):6-7, 封3
doi: 10.3969/j.issn.1001-859X.2003.03.004
[19] Wang J, Wang YY, Yang G . Methods and modes about the theory of traditional Chinese prescription composition[J]. Zhongguo Zhong Yao Za Zhi, 2005,30(1):6-8
王阶, 王永炎, 杨戈 . 中药方剂配伍理论研究方法和模式[J]. 中国中药杂志, 2005,30(1):6-8
[20] Wang R . To realize the best ratio of compatibility of Chinese herb compound with ED-NM-MO triple-expansion method[M]. Beijing: Doctor Thesis of Beijing University of Chinese Medicine, 2004: 4-5
王睿 . 实现复方剂量配比优化的ED-NM-MO三联法[M]. 北京: 北京中医药大学博士论文集, 2004: 4-5
[21] Tverskoy M, Ben-Shlomo I, Ezry J, Finger J, Fleyshman G . Midazolarn acts synergistically with methohexitone for induction of anesthesia[J]. Br J Anesth, 1989,63(1):109-112
doi: 10.1093/bja/63.1.109 pmid: 2765334
[22] Chou TC, Talalay P . Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors[J]. Eur J Biochem, 1981,115(1):207-216
[23] Zhou YM, Zhou ZT . On the effect of four Chinese herbal medicines on human buccal cancer cell line(HB)[J]. Lin Chuang Kou Qiang Yi Xue Za Zhi, 2008,24(1):3-5
周永梅, 周曾同 . 中药单方和复方对人颊癌细胞株体外抑制作用研究[J]. 临床口腔医学杂志, 2008,24(1):3-5
[24] Zheng QS, He YC, Yang J, Xu L, Lu YH, Liu HX, Chen JC, Sun RY . An approach for the analysis of pharmacodynamic interactions and the simulation of combined response[J]. Zhongguo Yao Li Xue Tong Bao, 2007,23(8):1106-1112
doi: 10.3321/j.issn:1001-1978.2007.08.030
郑青山, 何迎春, 杨娟, 许羚, 吕映华, 刘红霞, 陈君超, 孙瑞元 . 药物相互作用分析与复方药效模拟: 一个方法学研究[J]. 中国药理学通报, 2007,23(8):1106-1112
doi: 10.3321/j.issn:1001-1978.2007.08.030
[25] Li S, Wang YY, Ji L, Li YD . A discussion and case study of complexities in traditional Chinese medicine[J]. Xi Tong Fang Zhen Xue Bao, 2002,14(11):1429-1431
李梢, 王永炎, 季梁, 李衍达 . 复杂系统意义下的中医药学及其案例研究[J]. 系统仿真学报, 2002,14(11):1429-1431
[26] Yan SR, Wang Y, Qiao YJ . Realization of TCM complex adaptive system based on multi-agent modeling[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2007,30(10):653-655
颜素容, 王耘, 乔延江 . 基于多主体的中医药复杂适应系统实现途径[J]. 北京中医药大学学报, 2007,30(10):653-655
[27] Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yan XJ, Xu F, Wang BS, Mao JH, Shen ZX, Chen SJ, Chen Z . Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia[J]. Proc Natl Acad Sci U S A, 2008,105(12):4826-4831
doi: 10.1073/pnas.0712365105
[1] Jian-sheng Li, Xue-fang Liu, Hao-ran Dong, Wan-chun Zheng, Su-xiang Feng, Yan-ge Tian, Peng Zhao, Jin-di Ma, Zhou-xin Ren, Yang Xie. Effective-constituent compatibility-based analysis of Bufei Yishen formula, a traditional herbal compound as an effective treatment for chronic obstructive pulmonary disease. Journal of Integrative Medicine, 2020, 18(4): 351-362.
[2] Stefania Lamponi, Anna Maria Aloisi, Claudia Bonechi, Marco Consumi, Alessandro Donati, Gemma Leone, Claudio Rossi, Gabriella Tamasi, Luana Ghiandai, Ersilia Ferrini, Paolo Fiorenzani, Ilaria Ceccarelli, Agnese Magnani. Evaluation of in vitro cell and blood compatibility and in vivo analgesic activity of plant-derived dietary supplements. Journal of Integrative Medicine, 2019, 17(3): 213-220.
[3] Monireh Sadat Motaharifard, Zahra Jafari, Maryam Sadat Paknejad, Laleh Oveidzadeh, Mehrdad Karimi. Prevention and treatment of constipation in children from the perspective of Iranian traditional medicine. Journal of Integrative Medicine, 2016, 14(6): 429-435.
[4] Liang-ping Hu, Xiao-lei Bao, Qi Wang . The balance principle in scientific research. Journal of Chinese Integrative Medicine, 2012, 10(5): 504-507.
[5] Xiao-ping Huang , Xiao-dan Liu , Chang-qing Deng . Effects of the combination of active component extracts from Astragalus membranaceus and Panax notoginseng on apoptosis, reactive oxygen species and mitochondrial membrane potential of PC12 cells with oxidative injury. Journal of Chinese Integrative Medicine, 2012, 10(10): 1127-1134.
[6] Han Xiang-hui, Ye Yi-yi, Guo Bao-feng, Liu Sheng. Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines. Journal of Chinese Integrative Medicine, 2012, 10(1): 67-75.
[7] Wei-yi Gong , Xin-min Zhang, Zi-yin Shen, Guo-rang Hu, Su-qin Zhang, Run-hong Liu, Wei-dong Zhang, Jing-cheng Dong. Optimal combination of baicalin, icariin and Astragalus saponin Ⅰ from a Chinese herbal compound Biminne. Journal of Chinese Integrative Medicine, 2010, 8(6): 541-547.
[8] Zhao-guo Li. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Syndrome Differentiation According to Eight Principles (Part three). Journal of Chinese Integrative Medicine, 2010, 8(6): 594-597.
[9] Wen-jie Mao , Long Chen, Chun-xin Yang, Ming-hui Yao, Zi-qin Zhao, Yi-wen Shen, Yue-qin Zhou, Ai-min Xue, Hong-mei Xu, Ming-chang Zhang. Effects of triptolide-medicated serum on secretion function of adrenocortical cells isolated from rats. Journal of Chinese Integrative Medicine, 2010, 8(6): 562-567.
[10] Zhao-guo Li. Comparative study on WHO Western Pacific Region and World Federation of Chinese Medicine Societies international standard terminologies on traditional medicine: Syndrome Differentiation According to Eight Principles (Part two). Journal of Chinese Integrative Medicine, 2010, 8(5): 494-499.
[11] Ming-hui Yang, Min Li, Yong-qi Dou, Yi Liu, Xiao-dong Luo, Jian-zong Chen, Heng-jun Shi. Effects of Bushen Huoxue Granule on motor function in patients with Parkinson’s disease: A multicenter, randomized, double-blind and placebo-controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(3): 231-237.
[12] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059.
[13] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052.
[14] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047.
[15] Wen-jun Wang, Da-jin Li, Jun Li, Wen-jiang Zhou. An in vitro study on neuroprotective effects of serum containing Gengnianchun decoction and its main monomers against amyloid beta protein-induced cellular toxicity. Journal of Chinese Integrative Medicine, 2010, 8(1): 67-73.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228